Ipsilesional spatial bias after a focal cerebral infarction in the medial agranular cortex: A mouse model of unilateral spatial neglect

Ishii, Daisuke; Osaki, Hirokazu; Yozu, Arito; Ishibashi, Kiyoshige; Kawamura, Kenta; Yamamoto, Shinjiro; Miyata, Mariko; Kohno, Yutaka

doi:10.1016/j.bbr.2020.113097

Cited by 7 publications

(15 citation statements)

References 38 publications

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“…Thus, lesion volume might influence the mechanisms of recovery, with predominantly intrahemispheric compensation for small lesions, and recruitment of circuits in the opposite, healthy hemisphere for larger lesions. More relevant to neglect, a mouse model of ipsilesional spatial bias after focal damage to the medial agranular cortex demonstrated that the extent of the postlesional bias, but not that of recovery, correlated with the lesion size [78]. This pattern of results suggests that recovery was based on neural plasticity not within the peri-infarct area, but in distal regions in the same or contralateral hemisphere.…”

Section: Where: Neglect Compensation In the Brain Spacementioning

confidence: 99%

From competition to cooperation: Visual neglect across the hemispheres

Bartolomeo

2021

Revue Neurologique

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Section: Where: Neglect Compensation In the Brain Spacementioning

confidence: 99%

From competition to cooperation: Visual neglect across the hemispheres

Bartolomeo

2021

Revue Neurologique

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“…In this study, we used focal photothrombotic infarction in the AGm as a stroke model [13,[17][18][19]. The detailed descriptions can be found in the previous study [13].…”

Section: Photothrombotic Infarction In the Agmmentioning

confidence: 99%

Role of the medial agranular cortex in unilateral spatial neglect

Ishii,

Osaki,

Yozu

et al. 2023

Preprint

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Unilateral spatial neglect (USN) results from impaired attentional networks and can affect various sensory modalities, such as visual and somatosensory. The rodent medial agranular cortex (AGm), located in the medial part of the forebrain from rostral to caudal direction, is considered a region associated with spatial attention. The AGm selectively receives multisensory input with the rostral AGm receiving somatosensory input and caudal part receiving visual input. Our previous study showed slower recovery from neglect with anterior AGm lesion using the somatosensory neglect assessment. Conversely, the functional differences in spatial attention across the entire AGm locations (anterior, intermediate, and posterior parts) are unknown. Here, we investigated the relationship between the severity of neglect and various locations across the entire AGm in a mouse stroke model using a newly developed program-based analysis method that does not require human intervention. Among the various lesion positions, acute severity was higher with the lesion in the intermediate rostrocaudal position. On the other hand, the recovery from USN-like behavior after this phase tended to be slower in cases with more rostral lesions in the AGm. Additionally, no motor paralysis was observed in any of the mice with lesions in each AGm. These results suggest that the intermediate rostrocaudal position of the AGm may significantly influence selection of the direction, regardless of the areas to which it is connected. On the contrary, recovery from USN-like behavior may be dependent on the areas to which it is connected.HighlightsLesion of the rodent medial agranular cortex (AGm) results in unilateral spatial neglect (USN).In the acute phase, the severity was higher with lesions in the intermediate AGm position.Recovery from somatosensory USN tended to be slower with rostral AGm lesions.Recovery from USN may depend on sensory modalities associated with the connected areas.Our results revealed location-dependent differences in attentional functions within the AGm.

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“…In egocentric hemineglect, the midline is determined from the central axis of the patient's neck, torso, and retina (spectator-oriented), whereas in allocentric hemineglect, the midline is determined from the central axis of the stimulus, regardless of its position in the environment (stimulus-oriented). In the vast majority of patients with the phenomenon of ignoring, egocentric hemineglect is observed [14,17]. In other words, a person with the lesion of the right hemisphere of the brain in egocentric neglect loses the ability to respond to information coming from the left side of the body, and in allocentric -the ability to respond to the left side of each object, regardless of the position of this object to the patient (Fig.…”

Section: Figure 1 the Concentration Of Norepinephrine On Functional Magnetic Resonance Imaging Of The Brain [13]mentioning

confidence: 99%

“…There are several approaches to the classification of hemineglect syndrome. The unilateral neglect can be classified as egocentric or allocentric ignoring [14]. This classification is built based on the perception of spatial landmarks [10].…”

mentioning

confidence: 99%

Складнощі Нейропсихологічної Діагностики Синдрому Неглекту В Рамках Менеджменту Пацієнтів З Ішемічним Інсультом

Vostrotin¹,

Litovchenko²,

Voitiuk³

2021

INJ

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The article considers the topical problem of neurology, neurobiology and cognitive psychology — the question of pathogenetic mechanisms of origin and development of unilateral neglect after a cerebral infarction. The paper analyzes the scientific literature on the neuropsychological signs of hemineglect syndrome, its causes, features, manifestations and methods of rehabilitation. The role of the laws of neuroaesthetics in the perception and reproduction of environmental information in the brain is shown. New data on the peculiarities of the influence of the laws of neuroaesthetics on the process of the unilateral neglect formation are presented. It is emphasized that the principles of neuroaesthetics in oxidative stress after vascular catastrophe of the brain create conditions for the development of the pathological circle, the manifestation of which is lack of attention and loss of ability to respond to stimuli in one half of the field of view. It is determined that the exact neuroanatomy of unilateral neglect is complex and remains the subject of future researches for further cognitive rehabilitation of patients after cerebral infarction.

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Ipsilesional spatial bias after a focal cerebral infarction in the medial agranular cortex: A mouse model of unilateral spatial neglect

Cited by 7 publications

References 38 publications

From competition to cooperation: Visual neglect across the hemispheres

From competition to cooperation: Visual neglect across the hemispheres

Role of the medial agranular cortex in unilateral spatial neglect

Складнощі Нейропсихологічної Діагностики Синдрому Неглекту В Рамках Менеджменту Пацієнтів З Ішемічним Інсультом

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