ObjectiveStudies reporting that highly intelligent individuals have more mental health disorders often have sampling bias, no or inadequate control group, or insufficient sample size. We addressed these caveats by examining the difference in the prevalence of mental health disorders between individuals with high and average general intelligence (g-factor) in the UK Biobank.MethodsParticipants with general intelligence (g-factor) scores standardized relative to the same-age UK population, were divided into 2 groups: a high g-factor group (g-factor 2 SD above the UK mean; N=16,137) and an average g-factor group (g-factor within 2 SD of the UK mean; N=236,273). Using self-report questionnaires and medical diagnoses, we examined group differences in prevalence across 32 phenotypes, including mental health disorders, trauma, allergies, and other traits.ResultsHigh and average g-factor groups differed across 15/32 phenotypes and did not depend on sex and/or age. Individuals with high g-factors had less general anxiety (OR=0.69) and PTSD (OR=0.67), were less neurotic (β=-0.12), less socially isolated (OR=0.85), and were less likely to have experienced childhood stressors and abuse, adulthood stressors, or catastrophic trauma (OR=0.69-0.90). They did not differ in any other mental health disorder or trait. However, they generally had more allergies (e.g., eczema; OR=1.13-1.33).ConclusionsThe present study provides robust evidence that highly intelligent individuals have no more mental health disorders than the average population. High intelligence even appears as a protective factor for general anxiety and PTSD.Key PointsQuestionAre high IQ individuals at increased risk of mental health disorders?FindingsIn the UK Biobank (N ≃ 7,266 - 252,249), highly intelligent individuals (2SD above the population mean) were less likely to suffer from general anxiety and PTSD, and no more likely to have depression, social anxiety, a drug use disorder, eating disorders, obsessive-compulsive disorder, bipolar disorder, and schizophrenia.MeaningContrary to popular belief, high intelligence is not a risk factor for psychiatric disorders and even serves as a protective factor for general anxiety and PTSD.