IR, 1H NMR, mass, XRD and TGA/DTA investigations on the ciprofloxacin/iodine charge-transfer complex

Refat, Moamen S.; El-Hawary, Waheed F.; Moussa, Mohamed

doi:10.1016/j.saa.2011.01.010

Cited by 31 publications

(14 citation statements)

References 39 publications

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“…The experimental oscillator strength (f) and transition dipole moment (µ) of newly formed charge transfer complexes were determined by formulae given in equation 1and (2) [29,30];…”

Section: Spectral Characteristics Of Charge Transfer Complexesmentioning

confidence: 99%

Charge Transfer Complexes of Gamma Aminobutyric Acid-Analogue, A Neurotransmitter: Synthesis and Spectrophotometric Determination

Sultana¹,

M²,

Ali³

2013

J Bioanal Biomed

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Here, we report spectrophotometric method for the determination of gabapentin through charge transfer complexes with σ and π acceptors and also with dye stuffs. The method involves ion-pair complex formation of gabapentin with ninhydrin, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, tetracyanoethylene, methyl orange and picric acid. The optimum conditions for the reactions and validation of described procedure have been studied. Resulting complexes absorb at 580, 315, 340, 464 and 342 nm in the Beer's law range of 2-22, 32-80, 40-360, 12-96 and 15-135 µg mL-1 with correlation coefficient greater than 0.998 in each case respectively. The proposed method was applied successfully for the determination of gabapentin in pharmaceutical formulations. Satisfactory recovery values suggest that the method is reliable for the determination of gabapentin in pharmaceutical formulations without interference of excipients. In addition, the spectral characteristics including oscillator's strength, dipole moment, ionization potential, energy of complexes, resonance energy and also the thermodynamic parameters i.e. association constant and Gibb's free energy changes have been determined. Benesi-Hildebrand plots for each complex have been constructed. Further, solid charge transfer complexes of gabapentin were synthesized and characterized by IR spectroscopy.

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“…The experimental oscillator strength (f) and transition dipole moment (µ) of newly formed charge transfer complexes were determined by formulae given in equation 1and (2) [29,30];…”

Section: Spectral Characteristics Of Charge Transfer Complexesmentioning

confidence: 99%

Charge Transfer Complexes of Gamma Aminobutyric Acid-Analogue, A Neurotransmitter: Synthesis and Spectrophotometric Determination

Sultana¹,

M²,

Ali³

2013

J Bioanal Biomed

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“…The experimental oscillator strength (f) and transition dipole moment (µ) is calculated from CT spectra making use of equation (1) and (2) [9,10]. f= (4.319×10-9) ε max .ν 1/2 (1)…”

Section: Determination Of Oscillator Strength (F) and Transition Dipomentioning

confidence: 99%

“…This type of complexation is widely applied since last decade to analyze and characterize many of organic compounds like carboxylic acids [6], amines [7] and so on. These are of great importance for determining a number of parameters like ionization potential [8], dipole moment [9], oscillator's strength [10] and resonance energy [11]. They are known to take part in many chemical reactions like addition, substitution and condensation reaction [12,13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Spectrophotometric Determination Ibuprofen Charge Transfer Complexes with P-Chloranil, 7,7,8,8-Tetracyanoquinodimethane, Bromothymol Blue, Methyl Orange and Picric Acid

M¹

2013

J Bioanal Biomed

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Three simple, sensitive and inexpensive spectrophotometric methods have been described for the assay of ibuprofen in bulk drugs and pharmaceutical formulations. The developed methods are based on the formation of colored charge transfer complexes of ibuprofen with p-chloranil, 7,7,8,8-tetracyanoquinodimethane, bromothymol blue, methyl orange and picric acid in acetonitrile as solvent. These newly formed complexes were found to absorb at 438, 394, 403, 418, 374 nm respectively. Optimizations of various experimental conditions are described. Beer's law obeyed in the concentration range6-54, 2-24, 4-28, 3-21 and 4-28 µgmL -1 with correlation coefficient >0.998 in each case and lower limit of detection values were 76, 90, 234, 63 and 189 ng mL -1 , respectively. The association constants and standard free energy changes were studied using Benesi-Hildebrand plots. Oscillator's strength, ionization potential and energy of complexes in the ground state for all the complexes have been calculated. For further confirmation, solid charge transfer complexes were synthesized and characterized by IR and 1 H-NMR spectroscopy. The applicability of the method was demonstrated by the determination of studied drugs in commercial tablets with satisfactory results. No interference from excipients was observed in the formulations.

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Section: Spectral Characteristicsmentioning

confidence: 99%

“…From the absorption spectra of each complex, different spectral [27] and transition dipole moment (µ) [28] were calculated using the formulae f = (4.319 x 10 -9 ) ε max .ν 1/2 and µ = 0.0958 (ε max .ν 1/2 /ν max ) 1/2 . The ionization potential (Ip) of free donor [27] in acetonitrile medium was determined using the equation I p = 5.76 + 1.53 x 10 -4 ν CT . Resonance energy (R N ) [29] and energy of charge transfer complexes (E CT ) [30] were calculated by employing the equations ε max = 7.7×10 -4 / [hν CT / R N -3.5] and E CT = 1243.667/λ CT , where ε max is the molar extinction coefficient at maximum absorbance, ν 1/2 is the band-width at half absorbance in cm -1 , ν max and ν CT are wave number in cm -1 and λ CT is the wavelength of charge transfer band.…”

Section: Spectral Characteristicsmentioning

confidence: 99%

The Use of Chloranilic Acid for the Spectrophotometric Determination of Three Macrolides through Charge Transfer Complex

Sultana¹

2013

Med chem

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In the present study, simple and fast spectrophotometric method have been reported for the determination of three macrolides i.e., erythromycin, roxithromycin and clarithromycin through charge transfer complexes. The method involves the interaction of macrolides with chloranilic acid in acetonitrile medium. Stoichiometry was found to be 1:1 for all the complexes. Under the optimized conditions, the complexes were found to be absorbed at 498, 496 and 491 nm with in the linearity range of 3-36, 4-40 and 8-40 µg mL -1 with minimum detection limit 190, 600 and 370 ng mL -1 for respectively. The corresponding molar absorptivity values were determined to be 2.07×10 4 , 1.81×10 4 and 1.67×10 4 Mol -1 cm -1 respectively. The data is discussed in terms of oscillator's strength, dipole moment, ionization potential, energy of complexes, resonance energy, association constant and Gibb's free energy changes. Benesi-Hildebrand plots for all complexes have been constructed. Furthermore, the methods were successfully applied for the determination of studied macrolides in pharmaceutical formulations. The interday and intraday precision and percent recovery values were evaluated. Results of analysis were validated successfully. Commonly present excipients did not show interference during analysis.

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IR, 1H NMR, mass, XRD and TGA/DTA investigations on the ciprofloxacin/iodine charge-transfer complex

Cited by 31 publications

References 39 publications

Charge Transfer Complexes of Gamma Aminobutyric Acid-Analogue, A Neurotransmitter: Synthesis and Spectrophotometric Determination

Charge Transfer Complexes of Gamma Aminobutyric Acid-Analogue, A Neurotransmitter: Synthesis and Spectrophotometric Determination

Synthesis and Spectrophotometric Determination Ibuprofen Charge Transfer Complexes with P-Chloranil, 7,7,8,8-Tetracyanoquinodimethane, Bromothymol Blue, Methyl Orange and Picric Acid

The Use of Chloranilic Acid for the Spectrophotometric Determination of Three Macrolides through Charge Transfer Complex

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