IR and ¹H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects

Abstract

A series of 2-Amino-4-isopropyl-6-methoxy-N-phenylpyrimidine-5-carboxamide compounds have been synthesized from various substituted dithioacetal and guanidine. The purities of these compounds were checked by their physical constants, UV, IR, NMR and MASS spectral data. The IR and 1 HNMR spectral data of these compounds have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed.

Selective cyclization of S‐substituted pyrimidinethione: Synthesis and antimicrobial evaluation of novel polysubstituted thiazolopyrimidine and thiazolodipyrimidine derivatives

“…They have been extensively utilized to prepare different fused heterocycles, including thiazolo‐, triazolo‐, pyrazolo‐, pyridothiazolo‐, and imidazothiazolo‐pyrimidines . Condensed pyrimidine derivatives have also been reported as antimicrobial and hypnotic drugs for the nervous system, with activities including anti‐inflammatory, anti‐HIV, antiparasitic, and antitumor and have been used as calcium‐sensing receptor antagonists, antiulceratives, and antimalarial agents. They are also used as cardiovascular agents and diuretic drugs …”

Effect of Substituents on Phenazine Derivatives by Spectral Studies

“…These chemical shifts were correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. In these correlations, the Hammett equation was taken in the form as, δ = δ 0 + ρσ (2) Where δ 0 is the chemical shift of the corresponding parent compound.…”

“…Nair et al, have studied the optical properties of phenazine-Ru complexes [17]. Qsar and qspr study was established with various compounds such as chalcones [18], pyrazolines [19], imines [20], flavones [21], pyrimidines [22], carboxamides [23], oxazines [24], epoxides [25], sulfonamides [26], acyl bromides [27], Tröger's bases [28], di-imines [29]and thiadiazoles [30].…”

Recent synthetic methodologies for pyrimidine and its derivatives

“…4 A few pyrimidine derivatives also show potassium-conserving diuretic and antimalarial activity. 5 Condensed pyrimidine derivatives have also been reported as antimicrobial and hypnotic drugs for the nervous system, 6 with activities including antiinflammatory, 7 anti-HIV, 8 antiparasitic, 9 and antitumor and uses as calcium-sensing receptor antagonists, 10 antiulceratives, 11 antimalarial and cardiovascular agents, 12 and diuretic drugs. 13…”