IR thermography-based monitoring of respiration phase without image segmentation

Mutlu, Kadir; Rabell, José Esquivelzeta; Olmo, Pamela Martin del; Haesler, Sebastian

doi:10.1016/j.jneumeth.2018.02.017

Cited by 43 publications

(35 citation statements)

References 18 publications

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“…In 2018, Mutlu et al [ 15 ] presented an approach for respiration monitoring in head-restrained rodents using thermal imaging. In contrast to our work, it is based on the fact that temperature around the nose varies during the respiratory cycle.…”

Section: Discussionmentioning

confidence: 99%

“…Albeit this is a good alternative to monitor respiratory activity, there is a drawback regarding the measurement principle that should be addressed. In the algorithm proposed by Mutlu et al [ 15 ], the nostrils of the rodent must be always in the field of view of the camera. By contrast, in our approach the position of the camera can be flexible.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, there have been increasing demands for unobtrusive and contactless monitoring modalities to refine animal experiments [ 15 , 16 ]. Thermal imaging, also infrared thermography (IRT), emerged as a promising monitoring technology in a wide spectrum of medical fields, including assessment of HR [ 13 , 17 ] and RR [ 18 , 19 ], monitoring of thermal regulation [ 20 ], as well as observation of circulation and perfusion dynamics [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…The first approach allows to monitor RR, based on thorax movements due to respiratory activity. Respiration is necessary for assessing the physiological and psychological state [ 15 ]. According to Cretikos et al, an abnormal RR is one of the earliest indicators of physiological distress [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Remote Welfare Monitoring of Rodents Using Thermal Imaging

Pereira

Kunczik

Zieglowski

et al. 2018

Sensors

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Animal research has always played a crucial role in various medical and scientific breakthroughs. They offer, inter alia, insights into diseases mechanisms, genetic predisposition to a disease, and drug therapy. However, the use of animals for medical research is a cause of major controversies and debates in modern science. To warrant high bioethical standards, new directives have been being adopted to replace animal research whenever possible, to reduce the number of animals, and to refine the procedures to minimize stress and pain. Here, we present two new approaches, based on thermal imaging (a remote and passive technology), to assess respiratory rate (RR) as well as exploratory behavior and general activity in rodents. In animal research, these parameters are gold standards for welfare assessment. The approaches were validated in a study conducted with both rats and mice. To test the feasibility of our algorithm to estimate RR, thermal videos from anesthetized rodents were acquired. The capability of the second approach to monitor activity was tested with videos of Open Field tests. Regarding RR, a high agreement between thermal imaging and gold standard (electrocardiography-derived RR) was achieved. The mean relative error averaged 0.50 ± 0.15 breaths/min and 4.55 ± 2.94 breaths/min for rats and mice, respectively. The second approach was capable of monitoring and tracking the activity of the rodents very well. This paper demonstrates that thermal imaging is a promising and relevant alternative for monitoring of RR and activity in rodents, thus contributing to the remote assessment of animal welfare.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Remote Welfare Monitoring of Rodents Using Thermal Imaging

Pereira

Kunczik

Zieglowski

et al. 2018

Sensors

View full text Add to dashboard Cite

show abstract

“…The second group includes different kinds of image sensing. Thermal images [9][10][11] measure the temperature variations between inhalation and exhalation phases with it not working if the nasal area is not visible. In recent years, several works have used the photoplethysmography technique, employed initially to measure cardiac frequency [12], to measures skin blood changes to track RR [13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

A Contactless Respiratory Rate Estimation Method Using a Hermite Magnification Technique and Convolutional Neural Networks

2020

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The monitoring of respiratory rate is a relevant factor in medical applications and day-to-day activities. Contact sensors have been used mostly as a direct solution and they have shown their effectiveness, but with some disadvantages for example in vulnerable skins such as burns patients. For this reason, contactless monitoring systems are gaining increasing attention for respiratory detection. In this paper, we present a new non-contact strategy to estimate respiratory rate based on Eulerian motion video magnification technique using Hermite transform and a system based on a Convolutional Neural Network (CNN). The system tracks chest movements of the subject using two strategies: using a manually selected ROI and without the selection of a ROI in the image frame. The system is based on the classifications of the frames as an inhalation or exhalation using CNN. Our proposal has been tested on 10 healthy subjects in different positions. To compare performance of methods to detect respiratory rate the mean average error and a Bland and Altman analysis is used to investigate the agreement of the methods. The mean average error for the automatic strategy is 3.28 ± 3.33% with and agreement with respect of the reference of ≈98%.

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Microfluidic Interfaces for Chronic Bidirectional Access to the Brain

Marcigaglia,

De Plus,

Vandendriessche

et al. 2024

Adv Healthcare Materials

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Two‐photon polymerization (TPP) is an additive manufacturing technique with micron‐scale resolution that is rapidly gaining ground for a range of biomedical applications. TPP is particularly attractive for the creation of microscopic three‐dimensional structures in biocompatible and noncytotoxic resins. Here, TPP is used to develop microfluidic interfaces which provide chronic fluidic access to the brain of preclinical research models. These microcatheters can be used for either convection‐enhanced delivery (CED) or for the repeated collection of liquid biopsies. In a brain phantom, infusions with the micronozzle result in more localized distribution clouds and lower backflow compared to a control catheter. In mice, the delivery interface enables faster, more precise, and physiologically less disruptive fluid injections. A second microcatheter design enables repeated, longitudinal sampling of cerebrospinal fluid (CSF) over time periods as long as 250 days. Moreover, further in vivo studies demonstrate that the blood‐CSF barrier is intact after chronic implantation of the sampling interface and that samples are suitable for downstream molecular analysis for the identification of nucleic acid‐ or peptide‐based biomarkers. Ultimately, the versatility of this fabrication technique implies a great translational potential for simultaneous drug delivery and biomarker tracking in a range of human neurological diseases.

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IR thermography-based monitoring of respiration phase without image segmentation

Abstract: The new algorithm facilitates the application of IR thermography for measuring respiration in biomedical research and in clinical settings.

Cited by 43 publications

References 18 publications

Remote Welfare Monitoring of Rodents Using Thermal Imaging

Remote Welfare Monitoring of Rodents Using Thermal Imaging

A Contactless Respiratory Rate Estimation Method Using a Hermite Magnification Technique and Convolutional Neural Networks

Microfluidic Interfaces for Chronic Bidirectional Access to the Brain

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