IR780-based nanomaterials for cancer imaging and therapy

Wang, Long; Niu, Chengcheng

doi:10.1039/d1tb00407g

Cited by 46 publications

(23 citation statements)

References 134 publications

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“…To meet this need, in this study, we rationally contrustructed a core/shell structrued poly(lactic-co-glycolic acid) (PLGA) nanoplatform, with 3BP encapsulated in the core and IR780 loaded in the shell (designated as 3BP@PLGA-IR780), for enhanced PDT (Scheme 1 ). IR780, a lipophilic small molecular with characteristically considerable absorption and fluorescence in the near-infrared (NIR) wavelength region [ 32 , 33 ], is used as a PS. These nanoplatforms could selectively accumulate and penetrate deeply in tumor tissues endowed by the nature of IR780 [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, mitochondria have gained recognition as a viable subcellular target to enhance efficacy of anticancer treatments [ 10 , 36 ]. To optimize therapeutic precision, we took advantage of the fluorescence (FL) and photoacoustic (PA) imaging capability of IR780 to monitor the tumor accumulation of these nanoplatforms [ 33 , 40 ]. Thus, highly efficient antitumor therapy can be achieved by concurrent oxygen consumption reduction, oxygen-augmented PDT, energy supply decrease, mitochondria-targeted/deep-penetrated nanoplatforms and PA/FL dual-modal imaging guidance.…”

Section: Introductionmentioning

confidence: 99%

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Mitochondria-targeted nanoplatforms for enhanced photodynamic therapy against hypoxia tumor

et al. 2021

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Background Photodynamic therapy (PDT) is a promising therapeutic modality that can convert oxygen into cytotoxic reactive oxygen species (ROS) via photosensitizers to halt tumor growth. However, hypoxia and the unsatisfactory accumulation of photosensitizers in tumors severely diminish the therapeutic effect of PDT. In this study, a multistage nanoplatform is demonstrated to overcome these limitations by encapsulating photosensitizer IR780 and oxygen regulator 3-bromopyruvate (3BP) in poly (lactic-co-glycolic acid) (PLGA) nanocarriers. Results The as-synthesized nanoplatforms penetrated deeply into the interior region of tumors and preferentially remained in mitochondria due to the intrinsic characteristics of IR780. Meanwhile, 3BP could efficiently suppress oxygen consumption of tumor cells by inhibiting mitochondrial respiratory chain to further improve the generation of ROS. Furthermore, 3BP could abolish the excessive glycolytic capacity of tumor cells and lead to the collapse of ATP production, rendering tumor cells more susceptible to PDT. Successful tumor inhibition in animal models confirmed the therapeutic precision and efficiency. In addition, these nanoplatforms could act as fluorescence (FL) and photoacoustic (PA) imaging contrast agents, effectuating imaging-guided cancer treatment. Conclusions This study provides an ideal strategy for cancer therapy by concurrent oxygen consumption reduction, oxygen-augmented PDT, energy supply reduction, mitochondria-targeted/deep-penetrated nanoplatforms and PA/FL dual-modal imaging guidance/monitoring. It is expected that such strategy will provide a promising alternative to maximize the performance of PDT in preclinical/clinical cancer treatment. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mitochondria-targeted nanoplatforms for enhanced photodynamic therapy against hypoxia tumor

et al. 2021

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“…At the same time, the nanomaterials were specially modified to trigger the production of endogenous oxygen, which enhanced the effect of photodynamic therapy ( Zhu et al, 2018 ; Liang et al, 2019 ). Drug-loaded nanomaterials with imaging capabilities could not only monitor the therapeutic effect of tumors, but also the provide targeting, pharmacokinetics, and sustained-release properties of drug-loaded nanomaterials ( Truffi et al, 2016 ; Zhang et al, 2020 ; Wang and Niu, 2021 ). Zwitterion-modified nanomaterials promoted drug aggregation and targeting in tumor sites ( Li G. et al, 2021 ).…”

Section: The Biomedical Applications Of Imageable Nanomaterialsmentioning

confidence: 99%

The Advances and Biomedical Applications of Imageable Nanomaterials

Xiang

Shi²,

Gao³

2022

Front. Bioeng. Biotechnol.

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Nanomedicine shows great potential in screening, diagnosing and treating diseases. However, given the limitations of current technology, detection of some smaller lesions and drugs’ dynamic monitoring still need to be improved. With the advancement of nanotechnology, researchers have produced various nanomaterials with imaging capabilities which have shown great potential in biomedical research. Here, we summarized the researches based on the characteristics of imageable nanomaterials, highlighted the advantages and biomedical applications of imageable nanomaterials in the diagnosis and treatment of diseases, and discussed current challenges and prospects.

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“…IR780, a small molecule cyanine dye with a strong optical property and excellent photoconversion efficiency following near infrared (NIR) irradiation, has attracted increasing attention in the field of cancer phototherapy ( Wang and Niu, 2021 ). IR780 can emit fluorescence with a high intensity, long retention time and deep penetration within the NIR region in tissue, which enables its wide utilization for NIR fluorescence (NIRF) and photoacoustic (PA) imaging applications ( Yang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

IR780 Based Sonotherapeutic Nanoparticles to Combat Multidrug-Resistant Bacterial Infections

et al. 2022

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Multidrug-resistant (MDR) bacterial strains have emerged and weakened the therapeutic effects of antibacterial drugs. Sonodynamic therapy (SDT) takes advantage of noninvasiveness and deep tissue-penetrating features and has been rejuvenated to combat MDR bacteria and their biofilm-associated infections. To improve the efficacy of antibacterial SDT, we first developed IR780-based PLGA nanoparticles as sonosensitizers for high-frequency ultrasound (US)-monitored antibacterial SDT of MRSA myositis by therapeutic low-frequency US. In this study, the developed shell-core-structured IR780@PLGA nanoparticles were designed with a polymer shell PLGA with the sonosensitizer IR780 loaded on. High-frequency diagnostic US was introduced to monitor the sonotherapeutic progression of bacterial myositis by therapeutic low-frequency US. Importantly, the in vitro and in vivo results confirmed that IR780@PLGA nanoparticles combined with US irradiation possess high efficiency for antibacterial therapy. This approach provides a simple and efficient strategy to monitor and combat MDR bacterial infection.

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IR780-based nanomaterials for cancer imaging and therapy

Abstract: IR780, a small molecule with a strong optical property and excellent photoconversion efficiency following near infrared (NIR) irradiation, has attracted increasing attention in the fields of cancer treatment and imaging....

Cited by 46 publications

References 134 publications

Mitochondria-targeted nanoplatforms for enhanced photodynamic therapy against hypoxia tumor

Mitochondria-targeted nanoplatforms for enhanced photodynamic therapy against hypoxia tumor

The Advances and Biomedical Applications of Imageable Nanomaterials

IR780 Based Sonotherapeutic Nanoparticles to Combat Multidrug-Resistant Bacterial Infections

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