IR780‐Loaded Hyaluronic Acid@Gossypol–Fe(III)–EGCG Infinite Coordination Polymer Nanoparticles for Highly Efficient Tumor Photothermal/Coordinated Dual Drugs Synergistic Therapy

Abstract

A novel strategy called “two‐stage dual‐synergistic tumor therapy (TDTT),” which combines photothermal therapy with infinite coordination polymers (ICPs) chemotherapy at the first stage in the short term and two drugs of ICPs synergistic chemotherapy (coordinated dual drugs chemotherapy) at the second stage in the long term, is proposed. This strategy is achieved by preparing IR780‐loaded hyaluronic acid (HA) encapsulated gossypol–Fe(III)–epigallocatechin gallate (EGCG) ICP nanoparticles (HA@IRGFE ICP NPs), which have IR780 inclusions, a natural gossypol, and EGCG coordinated with Fe3+ framework, and a HA shell. It is found that the HA@IRGFE ICP NPs’ diameter is 120.0 ± 39.5 nm and has tumor‐targeting ability and can be rapidly released in tumor environment. Their photothermal conversion efficiency is greatly improved to 47.8%, and the total combination index of TDTT is 0.38, which indicates an excellent synergistic therapy result. These HA@IRGFE ICP NPs show low toxicity with a high tolerated dose (30.0 mg kg−1), a high tumor inhibition rate of 98.7%, and a very low tumor recurrence rate over 60 days (12.5%) with TDTT strategy, indicating their great potential applications in the field of tumor therapy.

A Tumor-Targeting Near-Infrared Heptamethine Cyanine Photosensitizer with Twisted Molecular Structure for Enhanced Imaging-Guided Cancer Phototherapy

“…31 As shown in the Supporting Information, we measured the PCE of T780T to be 38.5% (Figure 2g,h), which is higher than most of the reported heptamethine cyanine PSs (PCE ≈ 3−20%). 8,22,32 To study the photothermal conversion mechanism of T780T, we compared the temperature change of IR780 (10 μM) and T780T (5 μM) at the same power density of 0.3 W cm −2 in DMSO as dispersed states and in H 2 O as aggregated states. As shown in Figures S5 and S6, for the same normalized concentration of IR780, the temperature elevations of T780T (5 μM) in both solvents were larger than those of IR780 (10 μM), indicating that the promising photothermal behavior of T780T was mainly caused by the involvement of the TPE unit.…”

“…Furthermore, IR780 could hopefully be retained in cancer cells because it exhibits resistance against the drug efflux transporter ATP-binding cassette (ABC) . However, similar to the other tricarbocyanine dyes, IR780 can be easily photobleached, and the photothermal conversion efficiency (PCE) is not adequately high . Moreover, any improvement in photostability and PCE by structural modifications may affect the tumor targeting properties of the dye, since the structure–activity relationship for tumor targeting is not clear yet .…”

“…14 However, similar to the other tricarbocyanine dyes, IR780 can be easily photobleached, and the photothermal conversion efficiency (PCE) is not adequately high. 22 Moreover, any improvement in photostability and PCE by structural modifications may affect the tumor targeting properties of the dye, since the structure− activity relationship for tumor targeting is not clear yet. 23 As far as we know, there have been no heptamethine dyes reported with both high PTT effect and maintained tumor-targeted retention.…”

Ion channel-targeting near-infrared photothermal switch with synergistic effect for specific cancer therapy

“…12,13 Benefiting from the inherently temperature-sensitive property of TRPV1, nanomaterials with the ability to convert the absorbed photon energy to heat energy would be ideal nanoagonists for remote-controlled activation of TRPV1 signaling. 15,16 Compared with other targeting moieties, such as folic acid and hyaluronic acid, 17–19 functionalization of nanomaterials with ligands to target TRPV1 channels offers not only the prospect of target recognition but also an effective route to spatiotemporally regulate cancer cellular activity. On the basis of this concept, Han and co-workers have demonstrated that copper sulfide nanoparticles can modulate TRPV1 channels and trigger the ion over-flux in cancer cells.…”

Visualizing Nucleation and Growth Process of Vanadium‐Supramolecular Nanoribbons Self‐Assembled by Rapid Cooling Method towards High‐Capacity Vanadium Nitride Anode Materials

“…Up to now, more than 20 000 different MSPs have been designed and prepared due to their huge application potential in many fields benefit from advantages on structural design. [2][3][4][5][6][7][8] The studies of these metal centers of MSPs that have received much attention in literature mainly focus on metals ions, such as Cr(III), Fe(III), Al(III), Mg(II), Mn(II), Cd(II), Co(II), Cu(II), Cu(I), Zn(II), and Zr(IV)), and their clusters, for examples, Zn 4 O(COO) 6 , Cu 2 (COO) 4 , Cr 3 O(H 2 O) 3 (COO) 6 , and Zr 6 O 4 (OH) 10 (H 2 O) 6 (COO) 6 ). [9] Amongst these, the studies on vanadium MSPs (V-Supramolecular) are far fewer than those tens of thousands of other metalsbased MSPs, considering the wide range of clusters and complexes that can be formed with vanadium nodes.…”