IR780-loaded zwitterionic polymeric nanoparticles with acidity-induced agglomeration for enhanced tumor retention

Lu, I-Lin; Liu, Te-I; Lin, Hsiao Chieh; Chang, Siou Han; Lo, Chun Liang; Chiang, Wen‐Hsuan; Chiu, Hsin Cheng

doi:10.1016/j.eurpolymj.2019.109400

Cited by 13 publications

(2 citation statements)

References 15 publications

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“…In order to improve the natural carrier properties of BSA, this protein was modified with SBMA yielding SBMA-g-BSA. Then, a simple nanoprecipitation method was used to produce IR780 loaded SBMA-g-BSA nanoparticles (IR/SBMA-BSA NPs) due to its simplicity and reproducibility (Figure 2 that IR/SBMA-BSA NPs display a spherical shape, a feature that was also observed in other IR780 loaded nanostructures prepared by the nanoprecipitation method (Alves et al, 2019;Lu et al, 2019;Pais-Silva et al, 2017). As importantly, spherical shaped nanomedicines have been associated to an increased uptake by cancer cells (Chithrani, 2010;Zhang et al, 2008).…”

Section: Formulation and Characterization Of Ir/sbma-bsa And Ir/bsa Npsmentioning

confidence: 99%

“…For instance, Lu et al prepared IR780 loaded PEGylated zwitterionic nanoparticles that could produce a temperature increase of 10.8 °C after 2 min of irradiation (808 nm, 1.0 W cm -2 ) at an IR780 concentration of 26.7 µg mL -1 (Lu et al, 2019). Herein, the IR/SBMA-BSA NPs generated a photoinduced heat of 13.2 °C after 2 min of irradiation (808 nm, 1.7 W cm -2 ) using 20 µg mL -1 of IR780.…”

Section: Nir Absorption and Phototherapeutic Capacity Of Ir/sbma-bsa Npsmentioning

confidence: 99%

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IR780 loaded sulfobetaine methacrylate-functionalized albumin nanoparticles aimed for enhanced breast cancer phototherapy

Alves

Melo‐Diogo

Lima‐Sousa

et al. 2020

International Journal of Pharmaceutics

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Section: Formulation and Characterization Of Ir/sbma-bsa And Ir/bsa Npsmentioning

confidence: 99%

Section: Nir Absorption and Phototherapeutic Capacity Of Ir/sbma-bsa Npsmentioning

confidence: 99%

IR780 loaded sulfobetaine methacrylate-functionalized albumin nanoparticles aimed for enhanced breast cancer phototherapy

Alves

Melo‐Diogo

Lima‐Sousa

et al. 2020

International Journal of Pharmaceutics

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Production, Characterization, and Application of Hydrophobin‐Based IR780 Nanoparticles for Targeted Photothermal Cancer Therapy and Advanced Near‐Infrared Imaging

Yang,

Wang,

Huang

et al. 2024

Adv Healthcare Materials

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As a promising approach for breast cancer treatment, photothermal therapy (PTT) features high spatial selectivity, noninvasiveness, and minimal drug resistance. IR780 (a near‐infrared fluorescent dye) serves as an effective photosensitizer in PTT cancer therapy. However, the clinical application of IR780 in PTT has been hindered by its poor water solubility and unstable photostability. In this study, a genetically engineered dual‐functional fusion protein tLyP‐1‐MGF6 is successfully constructed and expressed, which presents a novel use of hydrophobin MGF6 for its amphiphilicity combined with the tumor‐penetrating peptide tLyP‐1 to create an innovative carrier for IR780. These results show this fusion protein serving as a biodegradable and biocompatible carrier, significantly improves the water solubility of IR780 when formulated into nanoparticles. These studies demonstrate that the IR780@tLyP‐1‐MGF6 nanoparticles significantly enhance tumor targeting and photothermal therapeutic efficacy in comparison with control in vitro and in vivo. These advancements highlight the potential of the unique combination hydrophobin‐based IR780 delivery system as a multifunctional nanoplatform for integrated imaging and targeted photothermal treatment of breast cancer.

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Assessing the Combinatorial Chemo‐Photothermal Therapy Mediated by Sulfobetaine Methacrylate‐Functionalized Nanoparticles in 2D and 3D In Vitro Cancer Models

Mó

Alves

Melo‐Diogo

et al. 2020

Biotechnology Journal

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Combinatorial cancer therapies mediated by nanomaterials can potentially overcome the limitations of conventional treatments. These therapies are generally investigated using 2D in vitro cancer models, leading to an inaccurate screening. Recently, 3D in vitro spheroids have emerged in the preclinical testing stage of nanomedicines due to their ability to mimic key features of the in vivo solid tumors. Investigate the chemo-photothermal therapy mediated by Doxorubicin and IR780 loaded sulfobetaine methacrylate functionalized nanoparticles, for the first time, using monolayers of cancer cells and spheroids. In the 2D cancer models, the nanomaterials' mediated photothermal therapy, chemotherapy, and chemo-photothermal therapy reduced cancer cells' viability to about 58%, 29%, and 1%, respectively. Interestingly, when the nanomaterials' mediated photothermal therapy is tested on 3D spheroids, no cytotoxic effect is noticed. In contrast, the nanostructures' induced chemotherapy decreased spheroids' viability to 42%. On the other hand, nanomaterials' mediated chemo-photothermal therapy diminished spheroids' viability to 16%, being the most promising therapeutic modality. These results demonstrate the importance of using 3D spheroids during the in vitro screening of single/combinatorial therapies mediated by nanomaterials.

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IR780-loaded zwitterionic polymeric nanoparticles with acidity-induced agglomeration for enhanced tumor retention

Cited by 13 publications

References 15 publications

IR780 loaded sulfobetaine methacrylate-functionalized albumin nanoparticles aimed for enhanced breast cancer phototherapy

IR780 loaded sulfobetaine methacrylate-functionalized albumin nanoparticles aimed for enhanced breast cancer phototherapy

Production, Characterization, and Application of Hydrophobin‐Based IR780 Nanoparticles for Targeted Photothermal Cancer Therapy and Advanced Near‐Infrared Imaging

Assessing the Combinatorial Chemo‐Photothermal Therapy Mediated by Sulfobetaine Methacrylate‐Functionalized Nanoparticles in 2D and 3D In Vitro Cancer Models

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