Iranian plant <i>Eremurus persicus</i>: an overview of botany, traditional uses, phytochemistry and pharmacology

Beiranvand, Mohammad; Beiranvand, Fatemeh

doi:10.1080/14786419.2021.1916744

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…Briefly, the secondary metabolite (R)-ASME has been identified from Eremurus persicus Jaub & Spach) Boiss by our group in a drug discovery campaign (Rossi et al, 2017). This plant is well-known by the local people for its beneficial effects on human health, and traditional medicine recognizes different activities depending on the part of the plant considered (Beiranvand and Beiranvand, 2022). Of note, the neuroprotective activity of E. persicus extracts has never been documented before, thus representing a new potential application.…”

Section: Proteasome Activity In Sh-sy5y Cellsmentioning

confidence: 99%

Neurodegeneration: can metabolites from Eremurus persicus help?

Cavalloro,

Marchesi,

Linciano

et al. 2024

Front. Pharmacol.

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The number of patients affected by neurodegenerative diseases is increasing worldwide, and no effective treatments have been developed yet. Although precision medicine could represent a powerful tool, it remains a challenge due to the high variability among patients. To identify molecules acting with innovative mechanisms of action, we performed a computational investigation using SAFAN technology, focusing specifically on HuD. This target belongs to the human embryonic lethal abnormal visual-like (ELAV) proteins and plays a key role in neuronal plasticity and differentiation. The results highlighted that the molecule able to bind the selected target was (R)-aloesaponol-III-8-methyl ether [(R)-ASME], a metabolite extracted from Eremurus persicus. Notably, this molecule is a TNF-α inhibitor, a cytokine involved in neuroinflammation. To obtain a suitable amount of (R)-ASME to confirm its activity on HuD, we optimized the extraction procedure. Together with ASME, another related metabolite, germichrysone, was isolated. Both ASME and germichrysone underwent biological investigation, but only ASME confirmed its ability to bind HuD. Given the multifactorial nature of neurodegenerative diseases, we decided to investigate ASME as a proteasome activator, being molecules endowed with this kind of activity potentially able to counteract aggregations of dysregulated proteins. ASME was able to activate the considered target both in enzymatic and cellular assays. Therefore, ASME may be considered a promising hit in the fight against neurodegenerative diseases.

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Section: Proteasome Activity In Sh-sy5y Cellsmentioning

confidence: 99%

Neurodegeneration: can metabolites from Eremurus persicus help?

Cavalloro,

Marchesi,

Linciano

et al. 2024

Front. Pharmacol.

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“…The root of Eremurus persicus plant (Serish) is a well-known glue of plant origin in Iran that has been used for centuries as natural glue in the textile, carpentry, binding, and book restoration industries. Thin layer chromatographic (TLC) analysis of ethanolic extract of E. persicus root showed that it contains polyphenols, flavonoids, and naphthoquinones (Beiranvand and Beiranvand 2021). People traditionally collected the roots, dried and powdered them, and mixed them with water to make glue (Koohkesh et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Environment-friendly waterborne fire retardants for protection of wood and bark against fire flames

Hosseinashrafi,

Hosseinihashemi,

Gorji

et al. 2023

BioRes

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Flame retardancy was induced in maple (Acer velutinum) and ash (Fraxinus excelsior) wood and bark by means of mixtures consisting of bio-based materials such as starch (S) and glue (G) and water-based paint, MINWAX (M) in two different combined formulations with perlite (P) as the main fire retardant. The selected wood species as solid wood with two different treatable surfaces (with and without bark) were examined. The lowest and the highest mass loss occurred in the untreated-ash and untreated-maple wood samples with bark, while the lowest weight percent gain was related to PSGM-treated ash wood samples with bark, and the highest weight percent gain was related to PSGM-treated maple wood samples without bark. The lowest time to ignition and glowing point time were measured in the untreated-maple wood samples without bark, and the highest of them were measured in the PSGM-treated ash wood samples without bark. The effect of bark in the treated- and untreated-maple samples on the time to ignition and glowing point time was greater than the bark of treated- and untreated-ash samples, respectively. There was not any significant relationship between actual retention, weight percent gain, and mass loss for all treatments. However, there was significant difference between the individual and interaction agents on fire retardancy of treated and untreated samples.

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“…The genus Eremurus (an important genus of Xanthorrhoeaceae that comprises 62 species) is widely known as foxtail lily or desert candles (3). It is found on dry and stony grazed hillside.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activities of Eremurus spectabilis M. Bieb. Extracts and Sulfur Compounds

Bayrak¹,

Yanardağ²

2021

ejb

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Objective: Eremurus spectabilis M. Bieb. is grown in East and Southeast Mediterranean regions of Turkey, and is commonly used as an edible plant in these regions. The aim of the current study was to determine the antioxidant activities of different E. spectabilis M. Bieb. extracts and some sulfur compounds. Materials and Methods:In this study, the antioxidant activities of aqueous, ethanolic, and ethyl acetate extracts of E. spectabilis M. Bieb. and sulfur compounds (α-lipoic acid, cysteamine, cysteine, diallyl sulfide, glutathione, homocysteine, N-acetyl cysteine, vitamin U and 1,4-dithioerythritol) were assessed in several antioxidant tests. These tests included reducing power, cupric ion reducing antioxidant capacity, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging, 2,2-diphenyl-1-picrylhydrazyl radical scavenging, N,N-dimethyl-4-phenylenediamine dihydrochloride radical scavenging, superoxide anion radical scavenging, hydroxyl radical scavenging, metal chelating activities and ferric ion reducing antioxidant power. The phytochemical profiles and total phenolic and flavonoid contents of all extracts were investigated.Results: It was found out that the antioxidant activities of all the extracts and sulfur compounds generally increased with concentration increases, the highest antioxidant activity was found in ethyl acetate extract, while the aqueous extract was found to have the lowest antioxidant activity. Diallyl sulfide was found to have the highest antioxidant activity, whereas vitamin U had the lowest antioxidant activity. It was observed that all extracts of E. spectabilis M. Bieb. and the sulfur compounds showed antioxidant activity. Conclusion:The E. spectabilis M. Bieb. and sulfur compounds investigated in this study could be considered as a source of antioxidants.

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Iranian plant Eremurus persicus: an overview of botany, traditional uses, phytochemistry and pharmacology

Cited by 8 publications

References 22 publications

Neurodegeneration: can metabolites from Eremurus persicus help?

Neurodegeneration: can metabolites from Eremurus persicus help?

Environment-friendly waterborne fire retardants for protection of wood and bark against fire flames

Antioxidant Activities of Eremurus spectabilis M. Bieb. Extracts and Sulfur Compounds

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