Irbesartan administration therapeutically influences circulating endothelial progenitor cell and microparticle mobilization by involvement of pro-inflammatory cytokines

Georgescu, Adelina; Alexandru, Nicoleta; Nemecz, Miruna; Titorencu, Irina; Popov, Doina

doi:10.1016/j.ejphar.2013.04.004

Cited by 25 publications

(26 citation statements)

References 26 publications

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“…There were no differences in weight between the studied animal groups. These results were correlated with those obtained in our previously papers on the same experimental diet model of atherosclerosis …”

Section: Resultssupporting

confidence: 91%

“…These results were correlated with those obtained in our previously papers on the same experimental diet model of atherosclerosis. [29][30][31][32][33]…”

Section: Resultsmentioning

confidence: 99%

“…The generation of experimental diet model of atherosclerosis, the source for late EPC culture For this study, 60 male Golden Syrian hamsters aged 3 months were split into: (i) hypertensive-hyperlipidaemic hamsters (HH group)obtained by administering an ordinary feed enriched in 3% cholesterol, 15% butter and 8% NaCl, for 4 months; and (ii) control hamsters (C group)healthy animals who received classical food containing 1% NaCl. [29][30][31][32][33]70,71 Both groups of animals were kept under the same housing conditions that respect their needs.…”

Section: Methodsmentioning

confidence: 99%

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Microparticles of healthy origins improve endothelial progenitor cell dysfunction via microRNA transfer in an atherosclerotic hamster model

et al. 2017

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Section: Resultssupporting

confidence: 91%

“…These results were correlated with those obtained in our previously papers on the same experimental diet model of atherosclerosis. [29][30][31][32][33]…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Microparticles of healthy origins improve endothelial progenitor cell dysfunction via microRNA transfer in an atherosclerotic hamster model

et al. 2017

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“…Furthermore, hypertensive and hypercholesterolemic hamsters treated with irbesartan exhibit a decline in microparticle infiltration into the vascular wall. In addition, isolated microparticles show a decrease in expression of inflammatory markers (315). Conversely, there may be some benefit to microparticles.…”

Section: Microparticle and Exosomementioning

confidence: 99%

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

Forrester

Booz

Sigmund

et al. 2018

Physiological Reviews

812

780

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The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology and pathophysiology. However, many of the signaling mechanisms have been unclear. The angiotensin II (ANG II) type 1 receptor (ATR) is believed to mediate most functions of ANG II in the system. ATR utilizes various signal transduction cascades causing hypertension, cardiovascular remodeling, and end organ damage. Moreover, functional cross-talk between ATR signaling pathways and other signaling pathways have been recognized. Accumulating evidence reveals the complexity of ANG II signal transduction in pathophysiology of the vasculature, heart, kidney, and brain, as well as several pathophysiological features, including inflammation, metabolic dysfunction, and aging. In this review, we provide a comprehensive update of the ANG II receptor signaling events and their functional significances for potential translation into therapeutic strategies. ATR remains central to the system in mediating physiological and pathophysiological functions of ANG II, and participation of specific signaling pathways becomes much clearer. There are still certain limitations and many controversies, and several noteworthy new concepts require further support. However, it is expected that rigorous translational research of the ANG II signaling pathways including those in large animals and humans will contribute to establishing effective new therapies against various diseases.

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“…Here, we demonstrate the PMP/EPC contribution towards vascular dysfunction and atherosclerotic plaque progression/regression in vivo (Figure ). Because the HH hamster model has been extensively used in our previous studies to evaluate the pathophysiology of atherosclerosis (Alexandru et al., 2011; Georgescu et al., , Alexandru et al.,; Georgescu et al., ), we considered that this could be a useful tool to examine the involvement of PMPs/EPCs in atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Effects of transplanted circulating endothelial progenitor cells and platelet microparticles in atherosclerosis development

Georgescu

Alexandru

Andrei

et al. 2016

Biology of the Cell

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Irbesartan administration therapeutically influences circulating endothelial progenitor cell and microparticle mobilization by involvement of pro-inflammatory cytokines

Cited by 25 publications

References 26 publications

Microparticles of healthy origins improve endothelial progenitor cell dysfunction via microRNA transfer in an atherosclerotic hamster model

Microparticles of healthy origins improve endothelial progenitor cell dysfunction via microRNA transfer in an atherosclerotic hamster model

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

Effects of transplanted circulating endothelial progenitor cells and platelet microparticles in atherosclerosis development

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