Iridium-Catalyzed Asymmetric Hydrogenation of Unprotected β-Enamine Esters

Abstract

Category Metal-Catalyzed Asymmetric Synthesis and Stereoselective ReactionsKey words asymmetric hydrogenation b-enamine esters iridium Significance: Expanding their work on the asymmetric hydrogenation methodology, this work demonstrated a highly efficient enantioselective hydrogenation of unprotected b-enamine esters catalyzed by an iridium (S,S)-f-binaphane complex. The free b-enamine acids were obtained in excellent yields and enantioselectivities (for asymmetric hydrogenation of unprotected NH imines, see: