Iridium(III) and gadolinium(III) loaded and peptide-modified silica nanoparticles for photoluminescence and magnetic resonance (dual) imaging

Cheng, Meng; Zhou, Lefei; Ma, Junping; Mu, Juanjuan; Yi, Changqing; Li, Meijin

doi:10.1016/j.msec.2019.109972

“…The chelation of Gd 3+ onto the outer shell of the probe might contribute to a higher r 1 while containing a lower amount of Gd content, because r 1 depends on direct interactions between Gd 3+ and hydrogen protons. [22,41,44,45] Similarly, an obvious concentration-dependent enhancement in brightness was also observed in qualitative CT images of the nanotheranostic probe (Figure 2B). Notably, the slope of Hounsfield unit (HU) value for the probe was 69.04, substantially higher than that of Iopromide (4.9), [46] a widely used clinical CT contrast agent.…”

Section: In Vitro Imaging and Therapeutic Potentialsupporting

confidence: 60%

An MMP‐2 Responsive Nanotheranostic Probe Enabled Synergistic Therapy of Rheumatoid Arthritis and MR/CT Assessment of Therapeutic Response In Situ

Chen

¹

,

Dai

²

,

Ma

³

et al. 2023

Adv Healthcare Materials

Self Cite

View full text Add to dashboard Cite

This study reports a facile and green synthesis of a new multifunctional nanotheranostic probe for the synergistic therapy of rheumatoid arthritis (RA) and in situ assessment of therapeutic response. The probe is synthesized through a one‐step self‐assembly of two exquisitely designed peptide‐amphiphilic block copolymers (PEG‐DTIPA‐KGPLGVRK‐MTX and Pal‐GGGGHHHHD‐TCZ) under mild conditions, requiring minimal energy input. The resultant probe demonstrates excellent biocompatibility, water solubility, and colloidal stability. It exhibits a strong IL‐6R targeting ability toward inflamed joints, and releases drugs in an MMP‐2‐responsive manner. The co‐loading of methotrexate(MTX) and tocilizumab (TCZ) into the probe enables synergistic RA therapy with improved efficacy by simultaneously decreasing the activity of adenosine synthetase and interfering with the binding of IL‐6 to its receptor. In addition, the resultant probe exhibits a high r1 relaxation rate (7.00 mm−1 s−1) and X‐ray absorption capability (69.04 Hu mm−1), enabling sensitive MR and CT dual‐modal imaging for simultaneous evaluation of synovial thickness and bone erosion. Both in vitro experiments using lipopolysaccharide‐treated RAW264.7 cells and in vivo experiments using collagen‐induced arthritis mice demonstrate the probe's high effectiveness in synergistically inhibiting inflammation. This study provides new insights into RA theranostics, therapeutic monitoring, the design of multifunctional theranostic probes, and beyond.

show abstract

“…A recently reported Ru-cRGD (cyclic RGD) conjugate exhibited strong two-photon luminescence and showed preferential accumulation in malignant cells with promising potential as a theranostic agent [ 167 ]. In an alternative system, dual-imaging nanoprobes were prepared by conjugating iridium(III), gadolinium(III) and RGD onto silica nanoparticles [ 169 ]. The water-soluble particles permitted in vitro and in vivo studies using confocal luminescence imaging and magnetic resonance imaging.…”

Section: Rationale For Peptide Conjugation To Transition Row Metal Co...mentioning

confidence: 99%

Metal Peptide Conjugates in Cell and Tissue Imaging and Biosensing

Gkika

¹

,

Cullinane

²

,

Keyes

³

2022

View full text Add to dashboard Cite

Metal complex luminophores have seen dramatic expansion in application as imaging probes over the past decade. This has been enabled by growing understanding of methods to promote their cell permeation and intracellular targeting. Amongst the successful approaches that have been applied in this regard is peptide-facilitated delivery. Cell-permeating or signal peptides can be readily conjugated to metal complex luminophores and have shown excellent response in carrying such cargo through the cell membrane. In this article, we describe the rationale behind applying metal complexes as probes and sensors in cell imaging and outline the advantages to be gained by applying peptides as the carrier for complex luminophores. We describe some of the progress that has been made in applying peptides in metal complex peptide-driven conjugates as a strategy for cell permeation and targeting of transition metal luminophores. Finally, we provide key examples of their application and outline areas for future progress.

show abstract

“…A recently reported Ru-cRGD (cyclic RGD) conjugate exhibited strong two-photon luminescence and showed preferential accumulation in malignant cells with promising potential as a theranostic agent [167]. In an alternative system, dual-imaging nanoprobes were prepared by conjugating iridium(III), gadolinium(III) and RGD onto silica nanoparticles [169]. The watersoluble particles permitted in vitro and in vivo studies using confocal luminescence imaging and magnetic resonance imaging.…”

Section: Receptor-targeting Peptidesmentioning

confidence: 99%

Metal peptide conjugates in cell and tissue imaging and biosensing

Gkika

¹

,

Cullinane²,

Keyes³

2022

Topics in Current Chemistry Collections

1

0

View full text Add to dashboard Cite

Metal complex luminophores have seen dramatic expansion in application as imaging probes over the past decade. This has been enabled by growing understanding of methods to promote their cell permeation and intracellular targeting. Amongst the successful approaches that have been applied in this regard is peptide-facilitated delivery. Cell-permeating or signal peptides can be readily conjugated to metal complex luminophores and have shown excellent response in carrying such cargo through the cell membrane. In this article, we describe the rationale behind applying metal complexes as probes and sensors in cell imaging and outline the advantages to be gained by applying peptides as the carrier for complex luminophores. We describe some of the progress that has been made in applying peptides in metal complex peptide-driven conjugates as a strategy for cell permeation and targeting of transition metal luminophores. Finally, we provide key examples of their application and outline areas for future progress.

show abstract

Iridium(III) and gadolinium(III) loaded and peptide-modified silica nanoparticles for photoluminescence and magnetic resonance (dual) imaging

Cited by 16 publications

References 41 publications

An MMP‐2 Responsive Nanotheranostic Probe Enabled Synergistic Therapy of Rheumatoid Arthritis and MR/CT Assessment of Therapeutic Response In Situ

An MMP‐2 Responsive Nanotheranostic Probe Enabled Synergistic Therapy of Rheumatoid Arthritis and MR/CT Assessment of Therapeutic Response In Situ

Metal Peptide Conjugates in Cell and Tissue Imaging and Biosensing

Metal peptide conjugates in cell and tissue imaging and biosensing

Contact Info

Product

Resources

About