Iridocyclitis: incidence, distribution and health service usage

Knox, E G; Mayho, A.; Cant, W.; Truelove, P.

doi:10.1093/oxfordjournals.pubmed.a043318

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 After an initial episode of uveitis, 11.3% of the patients will within 5 years have at least one recurrence, and 2.5% of the patients will experience two recurrences. 8 The mechanisms contributing to the relapsing and remitting nature of chronic autoimmune uveitis are not understood, nor is it well understood how prolonged remission of this disease can be achieved.…”

mentioning

confidence: 99%

Following EAU Recovery There Is an Associated MC5r-Dependent APC Induction of Regulatory Immunity in the Spleen

Lee

Taylor

2011

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Following EAU Recovery There Is an Associated MC5r-Dependent APC Induction of Regulatory Immunity in the Spleen

Lee

Taylor

2011

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…In spite of all the overlapping immunoregulatory mechanisms that exist, uveitis occurs in approximately 0·2% of the US population [ 6 ], with autoimmunity contributing to approximately 50% of the aetiology. While 0·2% of the population is not classified as an orphan disease, the National Institute of Health (NIH) considers it a rare disease.…”

Section: Introductionmentioning

confidence: 99%

Ex-vivotolerogenic F4/80+ antigen-presenting cells (APC) induce efferent CD8+ regulatory T cell-dependent suppression of experimental autoimmune uveitis

Hsu

Mathew

Taylor

et al. 2014

Clinical and Experimental Immunology

View full text Add to dashboard Cite

It is known that inoculation of antigen into the anterior chamber (a.c.) of a mouse eye induces a.c.-associated immune deviation (ACAID), which is mediated in part by antigen-specific local and peripheral tolerance to the inciting antigen. ACAID can also be induced in vivo by intravenous (i.v.) inoculation of ex-vivo-generated tolerogenic antigen-presenting cells (TolAPC). The purpose of this study was to test if in-vitro-generated retinal antigen-pulsed TolAPC suppressed established experimental autoimmune uveitis (EAU). Retinal antigen-pulsed TolAPC were injected i.v. into mice 7 days post-induction of EAU. We observed that retinal antigen-pulsed TolAPC suppressed the incidence and severity of the clinical expression of EAU and reduced the expression of associated inflammatory cytokines. Moreover, extract of whole retina efficiently replaced interphotoreceptor retinoid-binding protein (IRBP) in the preparation of TolAPC used to induce tolerance in EAU mice. Finally, the suppression of EAU could be transferred to a new set of EAU mice with CD8+ but not with CD4+regulatory T cells (Treg). Retinal antigen-pulsed TolAPC suppressed ongoing EAU by inducing CD8+ Treg cells that, in turn, suppressed the effector activity of the IRBP-specific T cells and altered the clinical symptoms of autoimmune inflammation in the eye. The ability to use retinal extract for the antigen raises the possibility that retinal extract could be used to produce autologous TolAPC and then used as therapy in human uveitis.

show abstract

Intraocular Diseases – Anterior Uveitis

Bora

Kaplan²

2007

Chemical Immunology and Allergy

View full text Add to dashboard Cite

Uveitis is a general term for inflammatory disorders of the uveal tract and encompasses a wide range of underlying etiologies. It may be idiopathic, associated with systemic diseases or result from a variety of infectious agents. Uveitis is responsible for over 2.8% of blindness in the United States. Each year, 17.6% of active uveitis patients experience a transient or permanent loss of vision. Anterior uveitis (AU), which refers to inflammation within the anterior segment of the eye, is the most common form of uveitis. Experimental autoimmune AU (EAAU) is an organ-specific autoimmune disease of the eye, which serves as an animal model of idiopathic human AU. Recently, type I collagen was identified as the target autoantigen in EAAU. Thus, human AU may be an e xample of autoimmunity to local ocular collagen.

show abstract

Iridocyclitis: incidence, distribution and health service usage

Cited by 3 publications

References 0 publications

Following EAU Recovery There Is an Associated MC5r-Dependent APC Induction of Regulatory Immunity in the Spleen

Following EAU Recovery There Is an Associated MC5r-Dependent APC Induction of Regulatory Immunity in the Spleen

Ex-vivotolerogenic F4/80+ antigen-presenting cells (APC) induce efferent CD8+ regulatory T cell-dependent suppression of experimental autoimmune uveitis

Intraocular Diseases – Anterior Uveitis

Contact Info

Product

Resources

About