Iridoids and Sesquiterpenoids with NGF-Potentiating Activity from the Rhizomes and Roots of Valeriana fauriei

Guo, Yuanqiang; Xu, Jing; Li, Yushan; Watanabe, Ryuichi; Oshima, Yasukatsu; Yamakuni, Tohru; Ohizumi, Yasushi

doi:10.1248/cpb.54.123

Cited by 25 publications

(8 citation statements)

References 12 publications

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“…398 Kissoones A-C 470-472 and the compound 473 are four rearranged bicyclogermacrane derivatives, which have been isolated from the roots of Valeriana fauriei. 399,400 The biotransformations of the sesquiterpenes (+)-aristol-1(10)-ene and plagiochilide by three microorganisms, Chlorella fusca var. vacuolata, a Mucor species and Aspergillus niger, have been investigated.…”

Section: Aromadendrane Bicyclogermacrane Aristolane Sinulariolane and Valerenanementioning

confidence: 99%

Natural sesquiterpenoids

Fraga

2010

Nat. Prod. Rep.

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Section: Aromadendrane Bicyclogermacrane Aristolane Sinulariolane and Valerenanementioning

confidence: 99%

Natural sesquiterpenoids

Fraga

2010

Nat. Prod. Rep.

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“…Recent literature suggests that different compounds from natural sources in combination with NGF act synergistically to induce the growth of neurites. Hence natural products may harmonize very well for the treatment of neuronal injury [ 4 , 13 , 14 , 15 , 16 , 17 ]. Lately, many compounds from natural sources have been demonstrated to possess neurotrophic and neuroprotective abilities ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth

Koppula

Kim

et al. 2012

Molecules

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Neurite loss is one of the cardinal features of neuronal injury. Apart from neuroprotection, reorganization of the lost neuronal network in the injured brain is necessary for the restoration of normal physiological functions. Neuritogenic activity of endogenous molecules in the brain such as nerve growth factor is well documented and supported by scientific studies which show innumerable compounds having neurite outgrowth activity from natural sources. Since the damaged brain lacks the reconstructive capacity, more efforts in research are focused on the identification of compounds that promote the reformation of neuronal networks. An abundancy of natural resources along with the corresponding activity profiles have shown promising results in the field of neuroscience. Recently, importance has also been placed on understanding neurite formation by natural products in relation to neuronal injury. Arrays of natural herbal products having plentiful active constituents have been found to enhance neurite outgrowth. They act synergistically with neurotrophic factors to promote neuritogenesis in the diseased brain. Therefore use of natural products for neuroregeneration provides new insights in drug development for treating neuronal injury. In this study, various compounds from natural sources with potential neurite outgrowth activity are reviewed in experimental models.

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“…398 Kissoones A-C 470-472 and the compound 473 are four rearranged bicyclogermacrane derivatives, which have been isolated from the roots of Valeriana fauriei. 399, 400 The biotransformations of the sesquiterpenes (+)-aristol-1(10)-ene and plagiochilide by three microorganisms, Chlorella fusca var. vacuolata, a Mucor species and Aspergillus niger, have been investigated.…”

Section: Aromadendrane Bicyclogermacrane Aristolane Sinulariolane mentioning

confidence: 99%