Iris Atrophy After Administration of Intracameral Dexycu in Routine Cataract Surgery: A Case Series

Abstract

Dexycu (Icon Bioscience INC, Newark, CA) is an FDAapproved single-dose, sustained release intracameral steroid designed to mitigate postoperative inflammation after cataract surgery as an alternative to topical steroid therapy. The purpose of this study was to look at longterm and adverse events associated with Dexycu use. Eighteen eyes from nine patients who underwent cataract surgery were included. Patients were followed for an average of 97 days (range 28-319 days) after surgery on the first eye. Thirteen eyes were treated with Dexycu, and the other five eyes were treated with standard postoperative anti-inflammatory drops. Four of the thirteen eyes receiving Dexycu developed clinically evident iris atrophy (30.7%). None of the five eyes treated with traditional anti-inflammatory drops developed iris atrophy. The Dexycu intraocular dexamethasone implant was designed to mitigate postoperative inflammation and reduce need for topical therapy but may be associated with other potential adverse effects that warrant consideration.

Persistent Intraocular Residue with the Use of Dexycu® in Cataract Extraction: A Case Series

“…Possible adverse reactions listed by the FDA include increased intraocular pressure, corneal edema, and iritis [3]. Since the approval of Dexycu®, other complications have been reported such as iris atrophy [4]. However, intraocular lens (IOL) residue associated with the use of Dexycu® is not well studied.…”