Iris reconstruction

Crawford, Alexandra Z.; Freundlich, Simone; Zhang, Jie; McGhee, Charles N J

doi:10.4103/ojo.ojo_160_21

Cited by 4 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, this product has been discontinued in recent years in our medical centre. There are several products that could be applied for intraocular implantation and iris replacement, including the Ophtec 311 non‐foldable iris diaphragm IOL and the currently available HumanOptics and Reper NN devices 27–30 . The last two foldable prosthetic iris products have been proven to be able to successfully address the dual pathology of aniridia, whilst the domestic application is still limited.…”

Section: Discussionmentioning

confidence: 99%

Preclinical biocompatibility and biosafety evaluation of a new foldable brown diaphragm intraocular lens: An in vitro and in vivo study

Zhang

et al. 2023

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

Background: A new foldable brown diaphragm intraocular lens (IOL) was preclinically evaluated in vitro and in vivo by comparing its biocompatibility and biosafety with those of a commercially available IOL. Methods:The new foldable iris-diaphragm IOL is composed of hydrophobic acrylic material, with a transparent optical zone and surrounding brown diaphragm. Cellular experiments evaluating lens epithelial cell morphology, adhesion, and migration were conducted to exclude cytotoxic effects. Twelve New Zealand rabbits underwent implantation of a brown diaphragm IOL in one eye, whilst an additional 12 had a commercially available foldable IOL implanted, followed by slit-lamp evaluations of inflammatory reactions and capsular opacification. Corneal endothelial cells density was measured before and after implantation. Aqueous humour samples were obtained weekly for liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to investigate dye leakage from the brown-diaphragm IOL. Following 12 weeks of observation, haematoxylin and eosin staining of ocular tissue and scanning electron microscopy (SEM) of the IOL surface were performed. Results: Results from in vivo experiments found no statistically significant differences between the two groups in terms of postoperative inflammation and capsular biocompatibility. No significant changes in corneal endothelial cell density were observed in either group before and after surgery. LC-MS/MS analysis showed that the target dye was not detected in aqueous humour Keke Zhang and Shaohua Zhang contributed equally to this work.

show abstract

Section: Discussionmentioning

confidence: 99%

Preclinical biocompatibility and biosafety evaluation of a new foldable brown diaphragm intraocular lens: An in vitro and in vivo study

Zhang

et al. 2023

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

show abstract

Combined artificial iris and intraocular lens double-flanged scleral fixation in a patient with posttraumatic aniridia and aphakia

Roth,

Amon

2024

JCRS Online Case Rep

View full text Add to dashboard Cite

This article introduces a novel surgical approach to address traumatic aniridia and aphakia through combined artificial iris (AI) and intraocular lens (IOL) implantation using the Canabrava technique. The IOL is affixed to the AI through 2 prolene sutures, which are flanged in the sclera at 4 symmetrical points. Both the surgical procedures and the postoperative follow-up visits showed no complications. An improvement in function and visual outcomes was achieved. The studied alternative surgical method could improve the management of complex cases of traumatic aniridia and aphakia, offering both functional and aesthetic benefits to patients.

show abstract

Endocapsular artificial iris implantation for iris defects: Reducing symptoms, restoring visual function and improving cosmesis

Crawford

Freundlich

Lim

et al. 2022

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

Background: To investigate repair of iris defects by endocapsular implantation of an artificial iris, in relation to visual outcomes, safety profile and patient satisfaction.Methods: Retrospective, consecutive case series from Greenlane tertiary teaching hospital and Eye Institute, Auckland, New Zealand. Medical records of patients implanted with an endocapsular artificial iris were reviewed and followed for minimum 3 months. Patient characteristics, surgical management, clinical outcomes and subjective responses were recorded.Results: Nineteen artificial irises were implanted in 18 patients. Etiologies were iris melanotic lesion excision (73.7%), trauma (10.5%), congenital aniridia (10.5%) and Urrets-Zavalia syndrome (5.3%). During postoperative follow-up [14.1 ± 12.4 months (range: 3 to 59 months)], best corrected visual acuity (BCVA) and intraocular pressure (IOP) did not change significantly [BCVA, 0.23 logarithm of the minimum angle of resolution (logMAR) (20/32 Snellen) preoperatively vs. 0.18 logMAR postoperatively (20/25 Snellen) (Z = À0.222, p = 0.824); IOP, 15 mmHg preoperatively vs. 17 mmHg postoperatively (Z = 1.377, p = 0.1447)]. Mild or self-limiting complications included: elevated IOP (42.1%), cystoid macular oedema (15.8%); persisting postoperative uveitis (15.8%) and minor vaulting of the prosthesis (15.7%). Moderate or severe complications included significant vaulting of prosthesis requiring surgical revision (5.3%) and a single eye (5.3%) with trabeculectomy and corneal graft failure. 94.4% of patients were very satisfied with the cosmesis and would be highly likely to have the procedure again. Conclusions: This study confirms that endocapsular insertion of an artificial iris is typically associated with good functional and cosmetic results and a relatively low risk of significant complications.

show abstract

Iris reconstruction

Cited by 4 publications

References 17 publications

Preclinical biocompatibility and biosafety evaluation of a new foldable brown diaphragm intraocular lens: An in vitro and in vivo study

Preclinical biocompatibility and biosafety evaluation of a new foldable brown diaphragm intraocular lens: An in vitro and in vivo study

Combined artificial iris and intraocular lens double-flanged scleral fixation in a patient with posttraumatic aniridia and aphakia

Endocapsular artificial iris implantation for iris defects: Reducing symptoms, restoring visual function and improving cosmesis

Contact Info

Product

Resources

About