Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions

Muñoz, Ilse Yessabel Martínez; Camarillo-Romero, Eneida; García, José de Jesús Garduño

doi:10.1155/2018/7816806

Cited by 81 publications

(61 citation statements)

References 68 publications

(112 reference statements)

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“…Irisin is secreted primarily by SkM as well as subcutaneous and visceral adipose tissues. However, as showed by immunohistochemical studies, smaller amounts of irisin are also produced by brain, heart, liver, pancreas, spleen, stomach, and testes [ 48 ]. Its level increases in the blood after physical exercise.…”

Section: Irisin Structure and Functionmentioning

confidence: 99%

Irisin and Autophagy: First Update

Pesce

Ballerini

Paolucci

et al. 2020

IJMS

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Aging and sedentary life style are considered independent risk factors for many disorders. Under these conditions, accumulation of dysfunctional and damaged cellular proteins and organelles occurs, resulting in a cellular degeneration and cell death. Autophagy is a conserved recycling pathway responsible for the degradation, then turnover of cellular proteins and organelles. This process is a part of the molecular underpinnings by which exercise promotes healthy aging and mitigate age-related pathologies. Irisin is a myokine released during physical activity and acts as a link between muscles and other tissues and organs. Its main beneficial function is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequential increase in thermogenesis. Irisin modulates metabolic processes, acting on glucose homeostasis, reduces systemic inflammation, maintains the balance between resorption and bone formation, and regulates the functioning of the nervous system. Recently, some of its pleiotropic and favorable properties have been attributed to autophagy induction, posing irisin as an important regulator of autophagy by exercise. This review article proposes to bring together for the first time the “state of the art” knowledge regarding the effects of irisin and autophagy. Furthermore, treatments on relation between exercise/myokines and autophagy have been also achieved.

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Section: Irisin Structure and Functionmentioning

confidence: 99%

Irisin and Autophagy: First Update

Pesce

Ballerini

Paolucci

et al. 2020

IJMS

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“…It has been suggested to be involved in glucose metabolism and thermogenesis, with improved glucose tolerance and decreased fasting insulin in mice treated with adenoviral vectors containing the gene that encodes irisin (FNDC5). In the clinical setting, lower levels of irisin have been described in people with type 2 diabetes, regardless of time of diagnosis, age, gender, and body mass index [12], findings that strongly suggest that this myokine could be involved in metabolic regulation.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 96%

Skeletal muscle adiponectin induction in obesity and exercise

et al. 2020

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“…Irisin is primarily secreted from skeletal muscles and adipose tissues. However, studies have shown that smaller quantities of irisin are produced from other organs such as the liver, pancreas, stomach, brain, heart, and spleen (Aydin et al, 2014;Martinez Munoz et al, 2018).…”

Section: A C Bmentioning

confidence: 99%

Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin

Park

Myint

Ito

et al. 2020

Front. Cell Dev. Biol.

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Integrins are transmembrane proteins that mediate cellular adhesion and migration to neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse physiological and pathological pathways. For integrin activation and ligand binding, bidirectional signaling across the cell membrane is needed. Integrins aberrantly activated under pathologic conditions facilitate cellular infiltration into tissues, thereby causing inflammatory or tumorigenic progressions. Thus, integrins have emerged to the forefront as promising targets for developing therapeutics to treat autoimmune and cancer diseases. In contrast, it remains a fact that integrin-ligand interactions are beneficial for improving the health status of different tissues. Among these ligands, irisin, a myokine produced mainly by skeletal muscles in an exercise-dependent manner, has been shown to bind to integrin αVβ5, alleviating symptoms under unfavorable conditions. These findings may provide insights into some of the underlying mechanisms by which exercise improves quality of life. This review will discuss the current understanding of integrin-ligand interactions in both health and disease. Likewise, we not only explain how diverse ligands play different roles in mediating cellular functions under both conditions via their interactions with integrins, but also specifically highlight the potential roles of the emerging ligand irisin in inflammation, cancer, and metabolic disease.

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Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions

Cited by 81 publications

References 68 publications

Irisin and Autophagy: First Update

Irisin and Autophagy: First Update

Skeletal muscle adiponectin induction in obesity and exercise

Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin

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