Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk

D’Amuri, Andrea; Sanz, Juana María; Lazzer, Stefano; Pišot, Rado; Šimunič, Boštjan; Biolo, Gianni; Zuliani, Giovanni; Gasparini, Mladen; Narici, Marco V.; Grassi, Bruno; Reggiani, Carlo; Nora, Edoardo Dalla; Passaro, Angelina

doi:10.3390/biology11070999

Cited by 3 publications

(4 citation statements)

References 35 publications

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“…Noteworthily, increased plasma levels have already been reported in humans after a 14-day episode of strict inactivity (bed-rest) [25]. These authors supported the idea that FNDC5/irisin is synthetized by adipose tissue rather than muscle.…”

Section: Fndc5/irisin Levels Are Increased In Smr Pupssupporting

confidence: 56%

Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain

Dupuis,

Girardie,

Van Gaever

et al. 2024

IJMS

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Interaction with the environment appears necessary for the maturation of sensorimotor and cognitive functions in early life. In rats, a model of sensorimotor restriction (SMR) from postnatal day 1 (P1) to P28 has shown that low and atypical sensorimotor activities induced the perturbation of motor behavior due to muscle weakness and the functional disorganization of the primary somatosensory and motor cortices. In the present study, our objective was to understand how SMR affects the muscle–brain dialogue. We focused on irisin, a myokine secreted by skeletal muscles in response to exercise. FNDC5/irisin expression was determined in hindlimb muscles and brain structures by Western blotting, and irisin expression in blood and cerebrospinal fluid was determined using an ELISA assay at P8, P15, P21 and P28. Since irisin is known to regulate its expression, Brain-Derived Neurotrophic Factor (BDNF) levels were also measured in the same brain structures. We demonstrated that SMR increases FNDC5/irisin levels specifically in the soleus muscle (from P21) and also affects this protein expression in several brain structures (as early as P15). The BDNF level was increased in the hippocampus at P8. To conclude, SMR affects FNDC5/irisin levels in a postural muscle and in several brain regions and has limited effects on BDNF expression in the brain.

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Section: Fndc5/irisin Levels Are Increased In Smr Pupssupporting

confidence: 56%

Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain

Dupuis,

Girardie,

Van Gaever

et al. 2024

IJMS

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“…According to D'Amuri et al, muscle-fat tissue crosstalk could represent a new biological target for the treatment of sarcopenia and muscle disuse atrophy [55]. Fourteen days of bed rest resulted in a loss of both mass and function in muscle but an increase in body fat tissue mass.…”

Section: Irisin and Its Role In Sarcopeniamentioning

confidence: 99%

Irisin and Its Role in Postmenopausal Osteoporosis and Sarcopenia

Falsetti,

Palmini,

Donati

et al. 2024

Biomedicines

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Menopause, an extremely delicate phase in a woman’s life, is characterized by a drop in estrogen levels. This decrease has been associated with the onset of several diseases, including postmenopausal osteoporosis and sarcopenia, which often coexist in the same person, leading to an increased risk of fractures, morbidity, and mortality. To date, there are no approved pharmacological treatments for sarcopenia, while not all of those approved for postmenopausal osteoporosis are beneficial to muscles. In recent years, research has focused on the field of myokines, cytokines, or peptides secreted by skeletal muscle fibers following exercise. Among these, irisin has attracted great interest as it possesses myogenic properties but at the same time exerts anabolic effects on bone and could therefore represent the link between muscle and bone. Therefore, irisin could represent a new therapeutic strategy for the treatment of osteoporosis and also serve as a new biomarker of sarcopenia, thus facilitating diagnosis and pharmacological intervention. The purpose of this review is to provide an updated summary of what we know about the role of irisin in postmenopausal osteoporosis and sarcopenia.

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“…The scientists concluded that there is a negative reverse connection relationship between muscle and adipose tissue. In particular, not only does muscle affect adipose tissue through irisin during exercise, but also adipose tissue protects muscle during the absence of physical activity [ 15].…”

Section: огляди літератури / Literature Reviewsmentioning

confidence: 99%

“…Особи, у яких виробляється більше ірізину характеризуються меншими втратами сили м'язів. Вчені дійшли висновку, що існує негативний зворотний зв'язок між м'язами та жировою тканиною, зокрема, не тільки м'язи впливають на жирову тканину через іризин під час тренування, але також жирова тканина захищає м'язи під час відсутності фізичної активності [15].…”

Section: основна частинаunclassified

The Participation of Irisin in the Mechanisms of Weight Loss in Obesity

Panchenko,

Drozdovska

2023

VPBM

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The article is devoted to analyzing the asymmetry as a common-biological law expressed at alive matter organization all levels with varieties dependently on gender, age, ethnic belonging, while representing the adaptation essential factor in a new and changeable conditions with understanding that disease represents dysadaptation expression. The authors paid separate attention to reviewing the literary data concerning to the brain and endocrinal system asymmetry, membranes asymmetry, handedness as asymmetry expression at populationspecies level the most comfortable for assessment with brilliant examples of the asymmetry and handedness applied study. They presented the literary and own data describing blood asymmetry study while mentioning a significant contribution of our educational establishment Physiology chair staff in it with the results received backgrounding. It is very important to remember about asymmetry of the Er morpho-functional peculiarities including hemostatic properties, coagulational and tissular hemostasis indices in the symmetrical vascular regions of the observed because they define "right" and "left" types of blood system activity. It is essentially to take blood from the left fourth finger and left cubital vein for analysis in the left-handed patients, while from the right ones -in the right-handed because there can be anemia and hypocoagulation in the blood of subdominant extremity that can be corrected even with medicines at once. It is wrongly to take blood from the left vessels one time and the right ones -another time. Also the authors paid significant attention to their researches on the topic about foreign students' typological belonging essentiality to take into consideration during work with them, in part in pedagogical process, to reach maximal individual approach in study and to provide their optimal multi-faceted adaptation.

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Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk

Cited by 3 publications

References 35 publications

Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain

Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain

Irisin and Its Role in Postmenopausal Osteoporosis and Sarcopenia

The Participation of Irisin in the Mechanisms of Weight Loss in Obesity

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