Irisin in atherosclerosis

Cheng, Zhe-Bin; Huang, Liang; Xiao, Xuan; Sun, Jia-Xiang; Zou, Zi-Kai; Jiang, Jie-Feng; Lu, Cong; Zhang, Hai-Ya; Zhang, Chi

doi:10.1016/j.cca.2021.08.022

Cited by 13 publications

(11 citation statements)

References 151 publications

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Section: Insulin Resistancementioning

confidence: 99%

“…77,79 Moreover, irisin plays a significant role in atherosclerosis. 80 It interferes with a plethora of intracellular pathways, potentiating direct or indirect vascular repair and alleviating vascular inflammation and crucial related disorders, discussed in the upcoming paragraphs, including dyslipidemia and oxidative stress. 80 Apelin is another relatively recently discovered peptide hormone, initially extracted from bovine stomachs.…”

Section: Inflammationmentioning

confidence: 99%

“…80 It interferes with a plethora of intracellular pathways, potentiating direct or indirect vascular repair and alleviating vascular inflammation and crucial related disorders, discussed in the upcoming paragraphs, including dyslipidemia and oxidative stress. 80 Apelin is another relatively recently discovered peptide hormone, initially extracted from bovine stomachs. Apelin is an endogenous ligand for the apelin receptor (APJ), a G-coupled protein receptor distributed abundantly in the human body.…”

Section: Inflammationmentioning

confidence: 99%

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Insulin resistance and cardiovascular disease

et al. 2023

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Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public health hazards, especially in today’s Western societies. A causal-effect relationship has been established that links IR with CVD. The mediating mechanisms are perplexing, under ongoing, rigorous investigation and remain to be fully elucidated. IR is a condition encompassing hyperglycemia and compensatory hyperinsulinemia. It occurs when insulin is not capable of exerting its maximum effects on target tissues, including skeletal muscles, liver and adipose tissue. This alteration of insulin signaling pathways results in the development of cardiometabolic disorders, including obesity, dyslipidemia, low-grade inflammation, endothelial dysfunction and hypertension, all of which are predisposing factors for atherosclerosis and CVD. The management of IR can be achieved through dietary modifications, the inclusion of regular exercise routines in everyday life, pharmacological agents and other interventions tailored to each individual patient’s needs. It is important to underline though that, although various antidiabetic drugs that may improve IR are available, no medications are as yet specifically approved for the treatment of IR. This narrative review will focus on the current scientific and clinical evidence pertaining to IR, the mechanisms connecting IR with CVD, as well as plausible strategies for a holistic, personalized approach for IR management.

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Section: Insulin Resistancementioning

confidence: 99%

Section: Inflammationmentioning

confidence: 99%

Section: Inflammationmentioning

confidence: 99%

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Insulin resistance and cardiovascular disease

et al. 2023

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“…In a study, an inverse relationship was reported between serum irisin levels and triglyceride, total cholesterol, and LDL cholesterol levels (Oelmann et al, 2016). Similarly, a recent study stated that as serum irisin levels increased, total cholesterol levels decreased (Cheng et al, 2021). Previous studies have shown that serum HDL levels increase with physical activity (Palazón-Bru et al, 2021;Sanllorente et al, 2021).…”

Section: Discussionmentioning

confidence: 94%

“…To date, many studies on its pathophysiology have been carried out. Dysfunction of dopaminergic neurons in the spinal cord, genetic factors, and brain iron deficiency is thought to play a role in the pathophysiology (Ainsworth et al, 2000;Allen et al, 2014;Chen et al, 2016;Cheng et al, 2021;Gonzalez-Latapi & Malkani, 2019;Harrison et al, 2018;Huang et al, 2020;Jodeiri Farshbaf & Alviña, 2021;Lourenco et al, 2019;Manconi et al, 2021;Phillips et al, 2014;Trenkwalder et al, 2018;World Health Organisation (WHO), 2008, Zhang et al, 2020. In a 2021 study, the involvement of the hippocampus and mesolimbic dopaminergic pathway was also pointed up in RLS patients (Mogavero et al, 2021) 2021; Lourenco et al, 2019;Phillips et al, 2014;Trenkwalder et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity?

Ulaş

Acar

et al. 2023

Brain and Behavior

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Introduction: Restless legs syndrome (RLS) is a common but underdiagnosed neurological syndrome. It is characterized by the feeling of discomfort and desire to move, especially in the lower extremities, which often occurs at night, and the cure or relief of symptoms with movement. Irisin is a hormonelike polypeptide that was first identified in 2012, weighs 22 kDa, consists of 163 amino acids, and is mainly synthesized in muscle. Its synthesis increases with exercise. Here in this study, we planned to investigate the relationship among serum irisin level, physical activity, lipid profile, and RLS. Material and methods:A total of 35 patients with idiopathic RLS and 35 volunteers were included in the study. Then, venous blood was taken from the participants in the morning after 12 h of night fasting. Results:The mean value of serum irisin level was 16.9 ± 14.1 ng/mL in the case group and 5.1 ± 5.9 ng/mL in the control group, which was statistically quite significant (p < .001). A significant efficiency (under the curve area 0.886 [0.804-0.967]) of irisin value was observed in the differentiation of patients in the case and control groups.Discussion: Serum irisin level was significantly higher in the case group than in the control group. In conclusion, we suggest that irisin may play a role in the pathophysiology of RLS independently of the intensity and duration of physical activity and anthropometric data, such as body weight, body mass index, and waist/hip ratio.

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