2020
DOI: 10.1016/j.bone.2020.115573
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Irisin inhibits osteocyte apoptosis by activating the Erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice

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Cited by 53 publications
(45 citation statements)
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“…This was reversed however in the group of ACLT mice that were injected with r-irisin at a daily dose of 100 µg/kg b.w. for 4 weeks (Table 5) [70]. Microtomography suggested that the irisin injections rescued the damaging effects of ACLT in the subchondral and in the tibial trabecular bone as confirmed with bone histomorphometry staining.…”
Section: Role Of Irisin On Bone Homeostasis: In Vivo Evidencementioning
confidence: 69%
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“…This was reversed however in the group of ACLT mice that were injected with r-irisin at a daily dose of 100 µg/kg b.w. for 4 weeks (Table 5) [70]. Microtomography suggested that the irisin injections rescued the damaging effects of ACLT in the subchondral and in the tibial trabecular bone as confirmed with bone histomorphometry staining.…”
Section: Role Of Irisin On Bone Homeostasis: In Vivo Evidencementioning
confidence: 69%
“…Exposure of MLO-Y4 osteocyte cells to irisin (100 ng/mL) for 24 h resulted in significantly reduced cyclic stretching-induced apoptosis and increased osteocyte proliferation [70]. Irisin treatment significantly reduced sclerostin mRNA level and increased the ratio of OPG/RANKL, suggesting improved bone remodeling.…”
Section: Osteocytesmentioning
confidence: 93%
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“…After treatment with PDGF‐BB, the phosphorylation of p38 decreased, resulting in down‐regulation of Bax and inhibition of caspase‐3‐dependent chondrocyte apoptosis. However, the activation of Erk is believed to be a negative factor for apoptosis and has been proven to be a protective factor in the progression of OA via apoptosis and autography 28‐31 . In our research, the phosphorylation of Erk decreased after MIA treatment.…”
Section: Discussionmentioning
confidence: 43%