Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review)

Abstract

Background: Regular exercise is an effective non-pharmacological therapy for treatment and prevention of cardiovascular disease (CVD). The therapeutic benefits of exercise are mediated partly through improved vascular and increase in metabolic health. Release of exercise-responsive myokines, including irisin, is associated with beneficial effects of exercise in CVD patients.Observations: The present review provides an overview of the role of exercise in cardiac rehabilitation of patients with myocardial infarction (MI). Further, the role of irisin as a motion-responsive molecule in improving vascular and metabolic health is explored. Possible mechanism of cardioprotective effect of irisin-mediated exercise on myocardial infarction are also summarized in this review.Conclusion and significance of the review: Irisin is associated with reduced inflammation, antioxidant properties, and anti-apoptotic effect, implying that it is a potential key mediator of the beneficial effects of exercise on vascular and metabolic health. The findings show that irisin is a promising therapeutic target for treatment of patients with cardiovascular disease, particularly post-MI. Further research should be conducted to elucidate the potential mechanisms of cardioprotective effects of irisin and explored whether irisin induced by exercise exerts rehabilitation effects post-MI.

The Role of FNDC5/Irisin in Cardiovascular Disease

“…In conclusion, Ir may mediate blood pressure reduction and vasodilation after exercise [100] and support cardiac rehabilitation processes [101].…”

The Importance of the Diaphragm Muscle in Cardiac Rehabilitation after Myocardial Infarction

“…This allows us to improve cardiac metabolism and cardiac perfusion, with benefits to the endothelial structure and function of the microvascular system; positively changes blood viscosity with antithrombotic effects [14]. Aerobic training could be organized as high-intensity interval (HIIT), for more delicate patients (bedridden, advanced age, reduced ejection frequency); the benefits are like continued training with less delicate patients [15]. Moderate-intense exercise is aerobic work between 60% and 85% of maximum heart rate or corresponding to a Rating of Perceived Exertion (RPE) value of 12-14 [16].…”

The emerging roles of irisin in vascular calcification

“…In addition to skeletal muscle, cardiac muscle is another source of irisin (20). As a myotropin, irisin is an important target for cardiac exercise rehabilitation, which can improve cardiac function after myocardial infarction (21). Irisin may alleviate ischemiareperfusion injury by reducing oxidative stress, improving mitochondrial health, and inhibiting inflammation (22).…”