Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome

Slate-Romano, John J; Yano, Naohiro; Zhao, Ting C.

doi:10.1016/j.mce.2022.111676

Cited by 31 publications

(12 citation statements)

References 106 publications

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“…Along with insulin sensitivity improvement, the reduction of the systemic immune-inflammation index was evidenced in the balance group and a trend to reduction in the folk-dance group. In the last published review, authors pointed out that irisin-mediated alterations in cytokine production results in reduced macrophage migration and infiltration, vascular leukocyte adhesion and migration, and acute phase inflammatory response 47 . Thus, it cannot be ruled out that the drop in SII was the effect of irisin's action.…”

Section: Discussionmentioning

confidence: 99%

Changes in selected exerkines concentration post folk-dance training are accompanied by glucose homeostasis and physical performance improvement in older adults

Rodziewicz-Flis

Kawa

Kaczor

et al. 2023

Sci Rep

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The study aimed to evaluate the impact of selected exerkines concentration induced by folk-dance and balance training on physical performance, insulin resistance, and blood pressure in older adults. Participants (n = 41, age 71.3 ± 5.5 years) were randomly assigned to folk-dance (DG), balance training (BG), or control group (CG). The training was performed 3 times a week for 12 weeks. Physical performance tests—time up and go (TUG) and 6-min walk test (6MWT), blood pressure, insulin resistance, and selected proteins induced by exercise (exerkines) were assessed at baseline and post-exercise intervention. Significant improvement in TUG (p = 0.006 for BG and 0.039 for DG) and 6MWT tests (in BG and DG p = 0.001), reduction of systolic blood pressure (p = 0.001 for BG and 0.003 for DG), and diastolic blood pressure (for BG; p = 0.001) were registered post-intervention. These positive changes were accompanied by the drop in brain-derived neurotrophic factor (p = 0.002 for BG and 0.002 for DG), the increase of irisin concentration (p = 0.029 for BG and 0.022 for DG) in both groups, and DG the amelioration of insulin resistance indicators (HOMA-IR p = 0.023 and QUICKI p = 0.035). Folk-dance training significantly reduced the c-terminal agrin fragment (CAF; p = 0.024). Obtained data indicated that both training programs effectively improved physical performance and blood pressure, accompanied by changes in selected exerkines. Still, folk-dance had enhanced insulin sensitivity.

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Section: Discussionmentioning

confidence: 99%

Changes in selected exerkines concentration post folk-dance training are accompanied by glucose homeostasis and physical performance improvement in older adults

Rodziewicz-Flis

Kawa

Kaczor

et al. 2023

Sci Rep

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“…Despite its widely described potential beneficial role for browning white adipose tissue and inducing thermogenesis gene expression, the therapeutic potential of irisin is controversial [65][66][67]. The discrepancy in the results principally regards its involvement in the inhibition of the adipogenesis process by downregulating PPARγ expression via the induction of Wnt/β-catenin signaling and the divergence between evidence observed in animal models and in humans [37,38,51]. Recent studies have indicated that irisin is a predictive marker of several pathologies, including sarcopenia, atherosclerosis, and heart failure [45,[68][69][70].…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis conducted by Jia and colleagues showed high circulating irisin levels in obese patients when compared to healthy controls [50]. Furthermore, in vitro and animal studies have attributed anti-inflammatory capabilities to irisin, including the reduction in pro-inflammatory cytokines and the proliferation of macrophages, induction of M2 polarization, inhibition of the inflammasome, and downregulation of NF-kB cell signaling [51].…”

Section: Introductionmentioning

confidence: 99%

Irisin: A Possible Marker of Adipose Tissue Dysfunction in Obesity

Tomasello

Pitrone

Guarnotta

et al. 2023

IJMS

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Adipose tissue (AT) secretes pro- and anti-inflammatory cytokines involved in AT homeostasis, including tumor necrosis factor-α (TNFα) and irisin. The functionality of AT is based on a regulated equilibrium between adipogenesis and extracellular matrix (ECM) remodeling. We investigated the contributions of adipose progenitors (ASCs) and adipocytes (AMCs) to TNFα-induced ECM remodeling and a possible implication of irisin in AT impairment in obesity. ASCs and AMCs were exposed to TNFα treatment and nuclear factor–kappa (NF-kB) pathway was investigated: Tissue Inhibitor of Metalloproteinase (TIMP-1), Twist Family Transcription Factor 1 (TWIST-1), and peroxisome proliferator-activated receptor-γ (PPARγ) expression levels were analyzed. The proteolytic activity of matrix metalloproteinases (MMPs) -2 and -9 was analyzed by zymography, and the irisin protein content was measured by ELISA. In inflamed AMCs, a TIMP-1/TWIST-1 imbalance leads to a drop in PPARγ. Adipogenesis and lipid storage ability impairment come with local tissue remodeling due to MMP-9 overactivation. In vitro and ex vivo measurements confirm positive correlations among inflammation, adipose secreting irisin levels, and circulating irisin levels in patients with visceral obesity. Our findings identify the NF-kB downstream effectors as molecular initiators of AT dysfunction and suggest irisin as a possible AT damage and obesity predictive factor.

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“…The upregulation of H 2 S levels can have beneficial effects on glucose homeostasis through activation of PGC-1α/FNDC5/irisin signaling pathway ( 46 ). The anti-inflammatory mechanism of irisin includes reducing macrophage proliferation and inducing alternating activation (M2 type) macrophage polarization ( 47 ). Recent studies demonstrated that different initiating CNS injuries could elicit two types of “reactive” astrocytes with different properties, type A1 is harmful and type A2 is beneficial or with reparative functions ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

CSE/H2S ameliorates colitis in mice via protection of enteric glial cells and inhibition of the RhoA/ROCK pathway

2022

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The enteric glial cells (EGCs) participate in the homeostasis of the gastrointestinal tract, and RhoA/ROCK signaling pathway plays a vital role in colonic tight junctions. Hydrogen sulfide (H2S) has been reported to alleviate colitis. However, the effect and mechanism of endogenous H2S on colitis remain unclear. This study established a Cystathionine-γ-lyase (CSE) knockout mouse model, a significant source of H2S production in the gut. The role of CSE-produced H2S on EGCs and the RhoA/ROCK signaling pathway was investigated in experimental colitis using CSE knockout (KO) and wild-type (WT) mice. CSE gene knockout animals presented with disease progression, more deteriorated clinical scores, colon shortening, and histological damage. EGCs dysfunction, characterized by decreased expression of the glial fibrillary acidic protein (GFAP), C3, and S100A10, was observed in the colon of WT and KO mice, especially in KO mice. RhoA/ROCK pathway was significantly upregulated in colon of colitis mice, which was more evident in KO mice. Pretreatment with NaHS, an exogenous H2S donor, significantly ameliorated mucosal injury and inhibited the expression of proinflammatory factors. Furthermore, we found that NaHS promoted the transformation of EGCs from “A1” to “A2” type, with decreased expression of C3 and increased expression of S100A10. These findings suggest that CSE/H2S protects mice from colon inflammation, which may be associated with preserving EGCs function by promoting EGCs transformation and inhibiting the RhoA/ROCK pathway.

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Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome

Cited by 31 publications

References 106 publications

Changes in selected exerkines concentration post folk-dance training are accompanied by glucose homeostasis and physical performance improvement in older adults

Changes in selected exerkines concentration post folk-dance training are accompanied by glucose homeostasis and physical performance improvement in older adults

Irisin: A Possible Marker of Adipose Tissue Dysfunction in Obesity

CSE/H2S ameliorates colitis in mice via protection of enteric glial cells and inhibition of the RhoA/ROCK pathway

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