Irisin Regulates Cardiac Responses to Exercise in Health and Diseases: a Narrative Review

Zhu, Baishu; Wang, Bin; Chen, Zhao; Wang, Yuanxin; Zhou, Yalan; Lin, Junjie; Zhao, Rongsheng

doi:10.1007/s12265-022-10310-4

Cited by 9 publications

(2 citation statements)

References 123 publications

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“…One of most common molecular mechanisms by which irisin counteracts the activity of RAAS and SAS is its ability to booster the activity of AMP kinase, but not Akt and MAP kinase, thereby protecting cardiomyocytes from hypertrophy induced by angiotensin II or phenylephrine, and suppressing fibrosis, gluconeogenesis, lipolysis, oxidative stress and inflammation [ 45 ]. The next mechanism is irisin-induced protective autophagy, which not only attenuates cardiac hypertrophy [ 46 ], but also improves the tolerability of cardiac myocytes against apoptosis and necrosis due to hypoxia and ischemia [ 47 ]. Moreover, irisin is able to regulate the metabolism of skeletal muscles in an autocrine manner [ 48 ], thereby reducing resistance to insulin, which plays a central role in altered reparative tissue potency in T2DM as well as in HF [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Interplay between Myokine Profile and Glycemic Control in Type 2 Diabetes Mellitus Patients with Heart Failure

et al. 2022

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Type 2 diabetes mellitus (T2DM) remains a powerful predictor of progressive heart failure (HF), but it is not clear whether altered glycemic control interferes with HF progression via an impaired profile of circulating myokines. The aim was to investigate plausible effects of glucose control on a myokine signature in T2DM patients affected by chronic HF. We selected 372 T2DM patients from the local database and finally included 314 individuals suffering from chronic HF and subdivided them into two groups according to glycosylated hemoglobin (HbA1c) levels (<6.9% and ≥7.0%). Echocardiography and Doppler examinations along with biomarker measurements were performed at the baseline of the study. The results showed that irisin levels were significantly lower in patients with HbA1c ≥ 7.0% than in those with HbAc1 < 6.9%, whereas concentrations of apelin, myostatin and adropin did not significantly differ between these two groups. We also identified numerous predictors of poor glycemic control, but only N-terminal brain natriuretic propeptide (odds ratio [OR] = 1.07; 95% confidence interval [CI] = 1.02–1.10, p = 0.04) and irisin (OR = 1.09; 95% CI = 1.04–1.17, p = 0.001) remained independent predictors of the dependent variable. In conclusion, we found that decreased levels of irisin were associated with poor glycemic control in T2DM patients with HF regardless of clinical conditions and other biomarkers.

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Section: Discussionmentioning

confidence: 99%

Interplay between Myokine Profile and Glycemic Control in Type 2 Diabetes Mellitus Patients with Heart Failure

et al. 2022

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“…By reducing ROS/p38 mitogen-activated protein kinase (MAPK)/ NF-κB signaling, irisin reduces endothelial injury and inflammation, and prevents foam cell development and monocyte adhesion caused by ox-LDL [33]. Exogenous irisin delivery decreases mitogenactivated protein kinase (MAPK) activation, the nuclear factor light chain enhancer of NF-κB translocation from the cytoplasm to the nucleus, and ROS levels in HUVECs treated with ox-LDL.…”

Section: Nf-κbmentioning

confidence: 99%

Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging

Wang,

Wang

2023

Aging and disease

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Aging is a natural process that affects all living organisms, including humans. Aging is a complex process that involves the gradual deterioration of various biological processes and systems, including the cardiovascular system. Vascular aging refers to age-related changes in blood vessels. These changes can increase the risk of developing cardiovascular diseases, such as hypertension, atherosclerosis, and stroke. Recently, an exercise-induced muscle factor, irisin, was found to directly improve metabolism and regulate the balance of glucolipid metabolism, thereby counteracting obesity and insulin resistance. Based on a growing body of evidence, irisin modulates vascular aging. Adenosine monophosphate-activated protein kinase (AMPK) serves as a pivotal cellular energy sensor and metabolic modulator, acting as a central signaling cascade to coordinate various cellular processes necessary for maintaining vascular homeostasis. The vascular regulatory effects of irisin are closely intertwined with its interaction with the AMPK pathway. In conclusion, understanding the molecular processes used by irisin to regulate changes in vascular diseases caused by aging may inspire the development of techniques that promote healthy vascular aging. This review sought to describe the impact of irisin on the molecular mechanisms of vascular aging, including inflammation, oxidative stress, and epigenetics, from the perspective of endothelial cell function and vascular macroregulation, and summarize the multiple signaling pathways used by irisin to regulate vascular aging.

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Diagnostic and predictive abilities of myokines in patients with heart failure

Berezin,

Berezina,

Hoppe

et al. 2024

Advances in Protein Chemistry and Structural Biology

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Irisin Regulates Cardiac Responses to Exercise in Health and Diseases: a Narrative Review

Cited by 9 publications

References 123 publications

Interplay between Myokine Profile and Glycemic Control in Type 2 Diabetes Mellitus Patients with Heart Failure

Interplay between Myokine Profile and Glycemic Control in Type 2 Diabetes Mellitus Patients with Heart Failure

Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging

Diagnostic and predictive abilities of myokines in patients with heart failure

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