Irisin stimulates gonadotropins gene expression in tilapia (Oreochromis niloticus) pituitary cells

Jiang, Qiqi; Zhang, Qianli; Lian, Anji; Xu, Yue

doi:10.1016/j.anireprosci.2017.06.018

Cited by 20 publications

(21 citation statements)

References 36 publications

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“…Poretsky et al (2017) showed that the administration of irisin in the murine pituitary cell line stimulates the LH production (Poretsky et al 2017). Similarly, it was reported that irisin stimulates gonadotropin gene expression in tilapia pituitary cells (Jiang et al 2017). Parallel to the previously mentioned studies, it was also found in the present study that the administration of chronic irisin increased serum LH concentration in female rats.…”

Section: Chronic Irisin Administration Altered Reproductive Endocrine Function In Female Ratssupporting

confidence: 89%

Irisin may have a role in pubertal development and regulation of reproductive function in rats

et al. 2020

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Physical exercise and body muscle/fat mass are known to affect the endocrine system, puberty onset and reproductive health. However, the potential effects of irisin, an adipo-myokine and exercise-induced hormone, have not yet been fully elucidated on reproductive maturation. Therefore, the present study aimed to determine the effects of irisin administration on pubertal maturation and reproductive system in female and male rats. Daily i.p. injection of irisin (100 ng/kg; from postnatal day 21 for about 10 weeks) delayed the ages at the vaginal opening (as an external index of puberty onset) and first estrus. Furthermore, continuous administration of irisin to female rats caused a significant decrease in serum follicle-stimulating hormone levels and an increase in serum luteinizing hormone and 17β-estradiol levels, as well as causing histopathological changes in the ovarian tissue. On the contrary, irisin administration to male rats did not modify the timing of puberty, as estimated by age at preputial separation. However, chronic exposure to irisin produced significant increases in serum luteinizing hormone and testosterone levels and also sperm concentration and seminiferous tubule diameter in male rats. In conclusion, irisin exposure has different effects on both pubertal maturation and reproductive system in female and male rats. The present findings reveal that chronic irisin exposure may lead to disorders in the female reproductive system and may have androgenic potential on the hypothalamic-pituitary-gonadal axis in males.

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Section: Chronic Irisin Administration Altered Reproductive Endocrine Function In Female Ratssupporting

confidence: 89%

Irisin may have a role in pubertal development and regulation of reproductive function in rats

et al. 2020

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“…In addition, irisin may improve hormonal profile through a direct stimulatory effect on GnRH release, this was reported by the observation of Jiang et al, [8] who noticed that irisin may serve as a novel intra-pituitary factor maintaining gonadotropins gene expression and increasing their mRNA levels, providing another mechanism for improving testicular function in this work.…”

Section: Discussionsupporting

confidence: 61%

“…It causes overexpression of Uncoupling Protein-1 (UCP1) in adipose tissue resulting in the browning of white adipocytes participating in the treatment of obesity [7] . Despite irisin plays an important role in energy homeostasis, its biological actions on reproduction remain unclear [8,9] .…”

Section: Introductionmentioning

confidence: 99%

Role of Irisin Administration in Modulating Testicular Function in Adult Obese Albino Rats

El-Malkey

2018

The Medical Journal of Cairo University

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Background: Irisin, exercise-induced myokine, is known to improve obesity-induced metabolic disturbances by enhancing thermogenesis and increasing energy expenditure. Recent studies have reported that irisin promoted cell proliferation and protected cells from apoptosis. However, the effects of irisin on testicular function in obese rats is still to be investigated. Aim of the Study: This study was designed to explore the probable effects of irisin treatment on modulating the adverse effects of obesity on testicular functions with a trial to clarify some of the possible underlying mechanisms. Material and Methods: Thirty adult male wistar albino rats (200±30g) were divided equally into 3 groups, group (I): Saline-vehicle treated normal fed group, group (II): Salinevehicle treated rats were fed a High Fat Diet (HFD) for 10 weeks. Group (III): Irisin treated HFD-fed rats for 10 weeks and irisin was injected subcutaneously (150µ l daily for 4 weeks). Rats were weighed and serum levels of glucose, insulin, lipid profile, FSH, LH, estradiol & testosterone levels, epididymal sperm count and motility, testicular Malondialdhyde (MDA) level, Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GP X) activities, testicular and epidydimal fat weights were estimated. Testicular histopathological study was done as well. Results: There was a significant increase in the Body Mass Index (BMI) together with deterioration of metabolic, gonadal functions and testicular oxidant/antio-oxidant system in group (II), while exogenous irisin administration in group (III) resulted in: Significant decrease in BMI, insulin resistance with improvement in lipid profile, significant increase in serum FSH, LH & testosterone, sperm count and motility in male rats. Together with marked improvement in the testicular histoarchitecture. Additionally, there was a significant increase in testicular SOD, CAT & GP X activities. However, it significantly decreased testicular MDA level. Conclusions: It could be suggested that irisin has a potential positive role against obesity-induced testicular dysfunction, which may be due to its role in maintenance of glucose & insulin homeostasis, its antioxidant properties and/ or maintenance of gonadal hormonal function via indirect and/or direct effects on the gonads.

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“…More recent data suggest a relationship between irisin and sex hormone metabolism. In primary cultures of tilapia pituitary cells, irisin is effective in stimulating both LHβ and FSHβ mRNA expression in vivo and in vitro [8]. Exogenous administration of irisin was significantly stimulating LH levels in obese female mice [9].…”

Section: Introductionmentioning

confidence: 93%

Irisin deletion induces a decrease in growth and fertility in mice

Luo

Qiao

Deng

et al. 2021

Reprod Biol Endocrinol

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Background Irisin, which is cleaved from fibronectin type III domain-containing protein 5 (Fndc5), plays an important role in energy homeostasis. The link between energy metabolism and reproduction is well known. However, the biological actions of irisin in reproduction remain largely unexplored. Methods In this study, we generated Fndc5 gene mutation to create irisin deficient mice. Female wild-type (WT) and Fndc5 mutant mice were fed with standard chow for 48 weeks. Firstly, the survival rate, body weight and fertility were described in mice. Secondly, the levels of steroid hormones in serum were measured by ELISA, and the estrus cycle and the appearance of follicles were determined by vaginal smears and ovarian continuous sections. Thirdly, mRNA-sequencing analysis was used to compare gene expression between the ovaries of Fndc5 mutant mice and those of WT mice. Finally, the effects of exogenous irisin on steroid hormone production was investigated in KGN cells. Results The mice lacking irisin presented increased mortality, reduced body weight and poor fertility. Analysis of sex hormones showed decreased levels of estradiol, follicle-stimulating hormone and luteinizing hormone, and elevated progesterone levels in Fndc5 mutant mice. Irisin deficiency in mice was associated with irregular estrus, reduced ratio of antral follicles. The expressions of Akr1c18, Mamld1, and Cyp19a1, which are involved in the synthesis of steroid hormones, were reduced in the ovaries of mutant mice. Exogenous irisin could promote the expression of Akr1c18, Mamld1, and Cyp19a1 in KGN cells, stimulating estradiol production and inhibiting progesterone secretion. Conclusions Irisin deficiency was related to disordered endocrinology metabolism in mice. The irisin deficient mice showed poor growth and development, and decreased fertility. Irisin likely have effects on the expressions of Akr1c18, Mamld1 and Cyp19a1 in ovary, regulating the steroid hormone production. This study provides novel insights into the potential role of irisin in mammalian growth and reproduction.

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Irisin stimulates gonadotropins gene expression in tilapia (Oreochromis niloticus) pituitary cells

Cited by 20 publications

References 36 publications

Irisin may have a role in pubertal development and regulation of reproductive function in rats

Irisin may have a role in pubertal development and regulation of reproductive function in rats

Role of Irisin Administration in Modulating Testicular Function in Adult Obese Albino Rats

Irisin deletion induces a decrease in growth and fertility in mice

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