IRMA: An Image Registration Meta-algorithm

Leung, Kelvin T.; Parker, D. Stott; Cunha, Alexandre; Hojatkashani, Cornelius; Dinov, Ivo D.; Toga, Arthur W.

doi:10.1007/978-3-540-69497-7_46

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…Figure 1 shows the pipeline workflow implementing the volumetric data analysis. The volumetric workflow pipeline consists of 4 main components– data preprocessing (intensity inhomogeneity correction [118] and skull-stripping [83; 84], cortical surface modeling [48], and tissue classification [134; 135]. The complete pipeline workflows are available as XML objects which can be downloaded, viewed and tested via the Pipeline environment (pipeline.loni.ucla.edu), see supplementary Files 1 and 2.…”

Section: 10 Methodsmentioning

confidence: 99%

Irritable bowel syndrome in female patients is associated with alterations in structural brain networks

Labus

Dinov

Jiang

et al. 2014

Pain

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Alterations in gray matter (GM) density/ volume and cortical thickness (CT) have been demonstrated in small and heterogeneous samples of subjects with different chronic pain syndromes, including irritable bowel syndrome (IBS). Aggregating across 7 structural neuroimaging studies conducted at UCLA between August 2006 and April 2011, we examined group differences in regional GM volume in 201 predominantly premenopausal female subjects (82 IBS, mean age: 32 ± 10 SD, 119 Healthy Controls [HCs], 30± 10 SD). Applying graph theoretical methods and controlling for total brain volume, global and regional properties of large-scale structural brain networks were compared between IBS and HC groups. Relative to HCs, the IBS group had lower volumes in bilateral superior frontal gyrus, bilateral insula, bilateral amygdala, bilateral hippocampus, bilateral middle orbital frontal gyrus, left cingulate, left gyrus rectus, brainstem, and left putamen. Higher volume was found for the left postcentral gyrus. Group differences were no longer significant for most regions when controlling for Early Trauma Inventory global score with the exception of the right amygdala and the left post central gyrus. No group differences were found for measures of global and local network organization. Compared to HCs, the right cingulate gyrus and right thalamus were identified as significantly more critical for information flow. Regions involved in endogenous pain modulation and central sensory amplification were identified as network hubs in IBS. Overall, evidence for central alterations in IBS was found in the form of regional GM volume differences and altered global and regional properties of brain volumetric networks.

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Section: 10 Methodsmentioning

confidence: 99%

Irritable bowel syndrome in female patients is associated with alterations in structural brain networks

Labus

Dinov

Jiang

et al. 2014

Pain

Self Cite

140

124

View full text Add to dashboard Cite

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“…The University of Southern California Laboratory of Neuroimaging pipeline ( http://pipeline.loni.usc.edu/ ), a graphical workflow environment was utilized for image preprocessing and CT and GMV analyses. All structural scans were first converted from DICOM to NIFTI, a format that could be analyzed, including intensity inhomogeneity correction,[ 35 ] skull-stripping,[ 36 , 37 ] and cortical surface modeling. [ 38 ] Gray matter thickness and volume were estimated using a well-validated method[ 39 ] implemented in FreeSurfer 4.0[ 38 ] (available free to the public, http://surfer.nmr.mgh.harvard.edu/fswiki and http://ucla.in/xSQPqT ).…”

Section: Methodsmentioning

confidence: 99%

Catecholaminergic Gene Polymorphisms Are Associated with GI Symptoms and Morphological Brain Changes in Irritable Bowel Syndrome

et al. 2015

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BackgroundGenetic and environmental factors contribute to the pathophysiology of irritable bowel syndrome (IBS). In particular, early adverse life events (EALs) and the catecholaminergic system have been implicated.AimsTo investigate whether catecholaminergic SNPs with or without interacting with EALs are associated with: 1) a diagnosis of IBS, 2) IBS symptoms and 3) morphological alterations in brain regions associated with somatosensory, viscerosensory, and interoceptive processes.MethodsIn 277 IBS and 382 healthy control subjects (HCs), 11 SNPs in genes of the catecholaminergic signaling pathway were genotyped. A subset (121 IBS, 209 HCs) underwent structural brain imaging (magnetic resonance imaging [MRI]). Logistic and linear regressions evaluated each SNP separately and their interactions with EALs in predicting IBS and GI symptom severity, respectively. General linear models determined grey matter (GM) alterations from the SNPs and EALs that were predictive of IBS.Results1) Diagnosis: There were no statistically significant associations between the SNPs and IBS status with or without the interaction with EAL after adjusting for multiple comparisons. 2) Symptoms: GI symptom severity was associated with ADRA1D rs1556832 (P = 0.010). 3) Brain morphometry: In IBS, the homozygous genotype of the major ADRA1D allele was associated with GM increases in somatosensory regions (FDR q = 0.022), left precentral gyrus (q = 0.045), and right hippocampus (q = 0.009). In individuals with increasing sexual abuse scores, the ADRAβ2 SNP was associated with GM changes in the left posterior insula (q = 0.004) and left putamen volume (q = 0.029).ConclusionIn IBS, catecholaminergic SNPs are associated with symptom severity and morphological changes in brain regions concerned with sensory processing and modulation and affect regulation. Thus, certain adrenergic receptor genes may facilitate or worsen IBS symptoms.

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“…A whole-brain binary mask and brain tissue type classification (GM, WM, and cerebrospinal fluid) were generated for each participant's raw baseline scan using a skull-stripping meta-algorithm. 31,32 This algorithm uses a skull-stripped reference image and identifies a consensus-based brain mask based on the results of several independent skull-stripping algorithms. The skull-stripped brain image data were then converted to binary masks and manually edited to eliminate any segmentation errors.…”

Section: Methodsmentioning

confidence: 99%

Delayed White Matter Growth Trajectory in Young Nonpsychotic Siblings of Patients With Childhood-Onset Schizophrenia

Gogtay

Hou²,

Stidd³

et al. 2012

Arch Gen Psychiatry

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Context Nonpsychotic siblings of patients with childhood-onset schizophrenia (COS) share cortical gray matter abnormalities with their probands at an early age; these normalize by the time the siblings are aged 18 years, suggesting that the gray matter abnormalities in schizophrenia could be an age-specific endophenotype. Patients with COS also show significant white matter (WM) growth deficits, which have not yet been explored in nonpsychotic siblings. Objective To study WM growth differences in non-psychotic siblings of patients with COS. Design Longitudinal (5-year) anatomic magnetic resonance imaging study mapping WM growth using a novel tensor-based morphometry analysis. Setting National Institutes of Health Clinical Center, Bethesda, Maryland. Participants Forty-nine healthy siblings of patients with COS (mean [SD] age, 16.1[5.3] years; 19 male, 30 female) and 57 healthy persons serving as controls (age, 16.9[5.3] years; 29 male, 28 female). Intervention Magnetic resonance imaging. Main Outcome Measure White matter growth rates. Results We compared the WM growth rates in 3 age ranges. In the youngest age group (7 to <14 years), we found a significant difference in growth rates, with siblings of patients with COS showing slower WM growth rates in the parietal lobes of the brain than age-matched healthy controls (false discovery rate, q = 0.05; critical P = .001 in the bilateral parietal WM; a post hoc analysis identified growth rate differences only on the left side, critical P =.004). A growth rate difference was not detectable at older ages. In 3-dimensional maps, growth rates in the siblings even appeared to surpass those of healthy individuals at later ages, at least locally in the brain, but this effect did not survive a multiple comparisons correction. Conclusions In this first longitudinal study of nonpsychotic siblings of patients with COS, the siblings showed early WM growth deficits, which normalized with age. As reported before for gray matter, WM growth may also be an age-specific endophenotype that shows compensatory normalization with age.

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IRMA: An Image Registration Meta-algorithm

Cited by 7 publications

References 3 publications

Irritable bowel syndrome in female patients is associated with alterations in structural brain networks

Irritable bowel syndrome in female patients is associated with alterations in structural brain networks

Catecholaminergic Gene Polymorphisms Are Associated with GI Symptoms and Morphological Brain Changes in Irritable Bowel Syndrome

Delayed White Matter Growth Trajectory in Young Nonpsychotic Siblings of Patients With Childhood-Onset Schizophrenia

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