Iron absorption.

Förth, W.; Rummel, W.

doi:10.1152/physrev.1973.53.3.724

Cited by 255 publications

(88 citation statements)

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“…This finding is consistent with the fact that iron absorption mainly occurs in the duodenum (1,6,36) and suggests that the low-affinity sites might be important in iron absorption .…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Characteristics of Iron Binding to Solubilized Brush Border Membrane of the Rat Intestine.

Ikeda-Moore

Orimo

Hisayasu

et al. 1995

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…This finding is consistent with the fact that iron absorption mainly occurs in the duodenum (1,6,36) and suggests that the low-affinity sites might be important in iron absorption .…”

Section: Discussionsupporting

confidence: 89%

“…Homeo stasis of body iron is primarily regulated by its absorption in the proximal small intestine (1). Iron takes several forms in the intestinal lumen and presumably their uptake requires different pathways dependent on their forms.…”

mentioning

confidence: 99%

Characteristics of Iron Binding to Solubilized Brush Border Membrane of the Rat Intestine.

Ikeda-Moore

Orimo

Hisayasu

et al. 1995

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

“…An alternative method for the determination of mucosal uptake in addition to retention of iron consists in injecting radioactive iron into a tied-off intestinal loop (Forth & Rummel 1973, Raja et al 1987.However, disadvantages of this method include the use 269 of anaesthesia and microsurgery. Moreover, the animal has to be killed at the end of the procedure which can last for a few minutes up to several hours.…”

Section: Discussionmentioning

confidence: 99%

In vivo mucosal uptake, mucosal transfer and retention of iron in mice

Santos¹,

Wienk

Schilham

et al. 1997

Lab Anim

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SummaryAn improved and sensitive method for studying iron absorption in mice with alterations in body iron stores is described. Mice with varying iron status were given a double isotopelabelled test dose containing S9Peand SICr as a non-absorbable indicator, via an oroesophageal needle. Using a whole-body counter it was possible to measure in vivo the initial mucosal iron uptake and long-term iron retention and to calculate mucosal iron transfer. A significant difference was demonstrated between normal and both anaemic and dietary iron-loaded mice with regard to the various steps of iron absorption. When mice were tested twice for iron absorption, the results were highly reproducible. In conjunction with other parameters, the method described is useful in studying the mechanism and the regulation of iron absorption in mice.

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“…However, the way iron absorption by the small intestine mucosal cell is adjusted to the requirements of the individual is unknown (7,23). Anemia (2,9,18), reduction in inspired oxygen tension (10,19,22,25), and increased marrow activity (2,9) are all associated with increased iron absorption and iron absorption decreases as these variables return to normal.…”

Section: Effect Of Blood Transfusions and Control Of Iron Absorptionmentioning

confidence: 99%

The Effect of Iron Supplements and Blood Transfusion on Iron Absorption by Low Birthweight Infants Fed Pasteurized Human Breast Milk

et al. 1978

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SummaryUsing serial metabolic balances, iron absorption was measured in six preterm infants (mean gestational age 29 weeks), and two fullterm small for gestational age (SGA) infants, between day 10 and 70 after birth. They were all fed breast milk. Iron supplements (2.5-13 mg/kg day) were given from day 30. Three preterm infants received blood transfusions for anemia. During the first 30 days of life iron balance was negative in the preterm infants (mean f SEM = -0.10 + 0.02 mg/kg day) and positive in the full term SGA infants (mean f SEM = 0.098 f 0.02 mg/kg day). In infants who were not transfused, absorption of supplementary iron was a linear function of iron intake, and corresponded closely to 34% absorption. An iron intake of 5-6 m d k g day resulted in the absorption of amounts of iron close to those being laid down in utero. Blood transfusion was followed by a reduction in iron absorption; in two cases it became negative, becoming positive again as the hemoglobin fell below about 12.0 d l 0 0 ml. These data show that a mechanism exists in preterm infants for the control of iron absorption which does not operate at the hemoglobin concentrations that prevail in such infants, unless they are transfused. SpeculationThe data suggest that in preterm infants there is a lack of correspondence between the amount of iron absorbed on the one hand, and hemoglobin synthesis and concentration in the blood on the other. We speculate that if preterm infants maintained their hemoglobin concentration at 11-12 d l 0 0 ml as do full term infants, iron absorption might come under feedback control rather than being a function of the concentration in the diet.

show abstract

Iron absorption.

Cited by 255 publications

References 0 publications

Characteristics of Iron Binding to Solubilized Brush Border Membrane of the Rat Intestine.

Characteristics of Iron Binding to Solubilized Brush Border Membrane of the Rat Intestine.

In vivo mucosal uptake, mucosal transfer and retention of iron in mice

The Effect of Iron Supplements and Blood Transfusion on Iron Absorption by Low Birthweight Infants Fed Pasteurized Human Breast Milk

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