1990
DOI: 10.1007/bf00189607
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Iron acquisition and the pathogenesis of meningococcal and gonococcal disease

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Cited by 15 publications
(8 citation statements)
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“…In this study, we investigated this topic by analyzing the protein profiles of conventionally grown, nonstressed, and nutrient-or oxygen-limited, stressed gonococci and found The existence of nutrient-specific regulation of protein synthesis in N. gonorrhoeae has been recognized previously by several investigators (12,28,32,36,62). The availability of iron, for instance, has been found to regulate the synthesis of various cytosolic and membrane proteins, including a number of proteins involved in iron acquisition, probably via the presence of iron-responsive elements adjacent to the genes involved (53). Our results confirm the presence of this type of response but, more importantly, indicate the existence of a general stress response, resulting in the synthesis of several additional proteins irrespective of the nature of the environmental stress.…”
Section: Discussionsupporting
confidence: 74%
“…In this study, we investigated this topic by analyzing the protein profiles of conventionally grown, nonstressed, and nutrient-or oxygen-limited, stressed gonococci and found The existence of nutrient-specific regulation of protein synthesis in N. gonorrhoeae has been recognized previously by several investigators (12,28,32,36,62). The availability of iron, for instance, has been found to regulate the synthesis of various cytosolic and membrane proteins, including a number of proteins involved in iron acquisition, probably via the presence of iron-responsive elements adjacent to the genes involved (53). Our results confirm the presence of this type of response but, more importantly, indicate the existence of a general stress response, resulting in the synthesis of several additional proteins irrespective of the nature of the environmental stress.…”
Section: Discussionsupporting
confidence: 74%
“…To obtain iron from the iron-restricted environment, microorganisms developed sophisticated mechanisms, e.g., siderophore systems (36), enzymatic breakdown of iron-binding proteins (37), reduction of the Fe 3ϩ complex to the Fe 2ϩ complex (leading to release of iron) (38), and interaction of receptors present on the microbial surface with the Fe-glycoprotein complex (39). The most important of these adaptive mechanisms is the siderophore system (36).…”
Section: Discussionmentioning
confidence: 99%
“…Also, Griffiths et al [10] and Ferreirds et al [6] found molecular masses of the transferrin receptor in N. meningitidis to be variable between 60 kDa and 90 kDa. Despite this, a recent review [11] considered the 98-kDa iron-restricted protein to be "in all strains and under all forms of iron limitation" the sole transferrin receptor.…”
Section: Introductionmentioning
confidence: 99%