Iron and Brain Disorders

Sadrzadeh, S.M. Hossein; Saffari, Yasi

doi:10.1309/ew0121lg9n3n1yl4

Cited by 51 publications

(41 citation statements)

References 76 publications

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“…An additional explanation could be differing amounts of sleep alterations. In particular, RLS and periodic limb movements during sleep have been associated with conditions characterized by compromised iron status 33 . It has been known that iron deficiency plays an important role in the physiopathology of the RLS characterized by an irresistible urge to move legs as well as motor restlessness.…”

Section: Methodsmentioning

confidence: 99%

Assessment of subjective sleep quality in iron deficiency anaemia

Sönmezer¹,

Ali²,

Korkmaz³

et al. 2015

Afr H. Sci.

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Objectives: We aimed to assess the effect of anemia on subjective sleep quality in patients with iron deficiency anemia (IDA). Methods: One hundred and four patients diagnosed with IDA and 80 healthy individuals, who are gender and age matched, were included in the study. All participants were requested to fill 3 forms: a socio-demographic form (age, gender, marital status, income level and educational status), hospital anxiety and depression (HAD) scale and pittsburgh sleep quality index (PSQI). Results: According to the HAD scale, the average anxiety score was found 9.24±4.37 in patients and 7.58± 4.07 in controls. And, the average depression score was 7.53±4.10 in patients and 6.41±2.74 in controls. The total sleep quality score was 6.71±3.02 in patients and 4.11±1.64 in controls. There was a statistically significant difference in terms of anxiety, depression and sleep quality scores. Linear regression analysis showed no association between anxiety and depression with poor sleeping. Corresponding author: Semiz Murat, Gülhane Tıp Akademisi Psikiyatri AD, TR-06020, Ankara, Turkey. Email:drmuratsemiz@hotmail.com Introduction After a negative iron balance in the body due to reasons such as chronic blood loss, increased iron demand, and absorption disorder, hemoglobin synthesis is compensated by mobilization of iron from stores and when the stores of iron fail to release adequate iron, iron deficiency anemia (IDA) develops 1 . Just like in our country, iron deficiency is the most common cause of anemia in the world and is more prevalent in women than men 2,3 . It has been known that more than 30% of those attending to hospitals in developed countries are anemic and the said ratio is much higher in developing countries.

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Section: Methodsmentioning

confidence: 99%

Assessment of subjective sleep quality in iron deficiency anaemia

Sönmezer¹,

Ali²,

Korkmaz³

et al. 2015

Afr H. Sci.

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“…Some investigators have suggested that the presence of hemorrhage in DAI/TAI is predictive of poor outcome (21). Recent neuropathological investigations show that microscopic analysis continues to detect more DAI/TAI lesions than radiologic imaging (22). Nevertheless, it is far too premature to make any significant statement about the correlation of small hemorrhages and outcomes.…”

Section: Conventional Mri Techniquesmentioning

confidence: 99%

Common data elements in radiologic imaging of traumatic brain injury

Haacke,

Duhaime,

Gean

et al. 2010

Magnetic Resonance Imaging

166

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Traumatic brain injury (TBI) has a poorly understood pathology. Patients suffer from a variety of physical and cognitive effects that worsen as the type of trauma worsens. Some noninvasive insights into the pathophysiology of TBI are possible using magnetic resonance imaging (MRI), computed tomography (CT), and many other forms of imaging as well. A recent workshop was convened to evaluate the common data elements (CDEs) that cut across the imaging field and given the charge to review the contributions of the various imaging modalities to TBI and to prepare an overview of the various clinical manifestations of TBI and their interpretation. Technical details regarding state-of-the-art protocols for both MRI and CT are also presented with the hope of guiding current and future research efforts as to what is possible in the field. Stress was also placed on the potential to create a database of CDEs as a means to best record information from a given patient from the reading of the images.

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“…In humans, the repercussions of heavy metal exposure can range from acute poisoning to progressive kidney, liver, and lung dysfunction and, in some instances, cancer. Although its true clinical and epidemiological significance remains to be determined, chronic exposure to heavy metals is often associated with muscular and neurological degenerative conditions reminiscent of muscular dystrophy, multiple sclerosis, Alzheimer disease, and Parkinson disease (2)(3)(4).…”

Section: ؉mentioning

confidence: 99%

CeHMT-1, a Putative Phytochelatin Transporter, Is Required for Cadmium Tolerance in Caenorhabditis elegans

Vatamaniuk

Bucher²,

Sundaram

et al. 2005

Journal of Biological Chemistry

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Phytochelatins (PCs), (␥-Glu-Cys) n Gly polymers that were formerly considered to be restricted to plants and some fungal systems, are now known to play a critical role in heavy metal (notably Cd 2؉ ) detoxification in Caenorhabditis elegans. In view of the functional equivalence of the gene encoding C. elegans PC synthase 1, ce-pcs-1, to its homologs from plant and fungal sources, we have gone on to explore processes downstream of PC fabrication in this organism. Here we describe the identification of a half-molecule ATP-binding cassette transporter, CeHMT-1, from C. elegans with an equivalent topology to that of the putative PC transporter SpHMT-1 from Schizosaccharomyces pombe. At one level, Ce-HMT-1 satisfies the requirements of a Cd . These results and those from our previous investigations of the requirement for PC synthase for heavy metal tolerance in C. elegans demonstrate PC-dependent, HMT-1-mediated heavy metal detoxification not only in S. pombe but also in some invertebrates while at the same time indicating that the action of Ce-HMT-1 does not depend exclusively on PC synthesis.The toxicity of supraoptimal levels of the essential heavy metals copper and zinc and of trace or higher levels of the nonessential heavy metals cadmium, arsenic, mercury, and lead is thought to result from the displacement of endogenous co-factors from their cellular binding sites, thiol-capping of essential proteins and peptides, and promotion of the formation of reactive oxygen species (1). In humans, the repercussions of heavy metal exposure can range from acute poisoning to progressive kidney, liver, and lung dysfunction and, in some instances, cancer. Although its true clinical and epidemiological significance remains to be determined, chronic exposure to heavy metals is often associated with muscular and neurological degenerative conditions reminiscent of muscular dystrophy, multiple sclerosis, Alzheimer disease, and Parkinson disease (2-4).Three classes of heavy metal-binding peptides are known to participate in the homeostasis and detoxification of heavy metals in most animals. These are the ubiquitous thiol tripeptide glutathione (GSH), a family of small (4 -8 kDa) cysteine-rich proteins termed metallothioneins, and several higher molecular mass albeit sequence-unrelated metal-binding proteins. In all of the plants studied and in some fungi (as exemplified by Schizosaccharomyces pombe and Candida glabrata) and some animals (as exemplified by the model nematode Caenorhabditis elegans), a third class of cysteine-rich peptides termed phytochelatins (PCs) 1 has also been shown to be involved in heavy metal detoxification.PCs, which constitute a family of short-chain heavy metalbinding peptides with the general structure (␥-EC) n Xaa, where n ϭ 2-11, are derived from GSH and related thiols in a ␥-glutamylcysteinyl transpeptidation reaction catalyzed by phytochelatin synthases (EC 2.3.2.15) (1,5,6). It is now almost 15 years since the partial purification of the enzyme capable of catalyzing PC synthesis (5), yet it is onl...

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Iron and Brain Disorders

Cited by 51 publications

References 76 publications

Assessment of subjective sleep quality in iron deficiency anaemia

Assessment of subjective sleep quality in iron deficiency anaemia

Common data elements in radiologic imaging of traumatic brain injury

CeHMT-1, a Putative Phytochelatin Transporter, Is Required for Cadmium Tolerance in Caenorhabditis elegans

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