Iron and infection

Barry, Dana; Reeve, A. W.

doi:10.1136/bmj.296.6638.1736-a

Cited by 7 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Within the following year the prevalence of slide-positive malaria was about 50% higher in the Fe-treated group, but there was no increase in the density of parasitaemia or rates of clinical malaria. In contrast to the study reported by Barry & Reeve (1988), there was no difference in the rate of fatal infections between the two groups. Moreover, in a study by Cantwell (1972) in which Maori newborn infants were randomly selected to receive iron dextran injections, a small but statistically significant reduction in hospitalization rates has been observed in the Fe-treated group.…”

Section: Clinical Studies I N Iron Deficiency and Overloadcontrasting

confidence: 99%

“…Barry & Reeve (1977) have reported an increased incidence of neonatal sepsis among Polynesian infants following the introduction of a prophylactic programme of intramuscular iron dextran therapy, and a decrease from 22 to 2 per 1000 in the incidence of sepsis after discontinuation of the programme. Unfortunately, the incidence of neonatal sepsis in this population before parenteral Fe therapy is unknown, although mortality rates increased after initiation of treatment (Barry & Reeve, 1988). As the entire population had been treated, there was no control population left for direct comparison.…”

Section: Clinical Studies I N Iron Deficiency and Overloadmentioning

confidence: 99%

See 1 more Smart Citation

Iron, infection and immune function

Hershko

1993

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Section: Clinical Studies I N Iron Deficiency and Overloadcontrasting

confidence: 99%

Section: Clinical Studies I N Iron Deficiency and Overloadmentioning

confidence: 99%

Iron, infection and immune function

Hershko

1993

Proc. Nutr. Soc.

View full text Add to dashboard Cite

“…In turn, iron partitioning within the host influences microbial niche tropism [6]. The impact of iron during bacterial infection is further illustrated by the observation that iron administration can increase mortality rates in infected patients [11], [12].…”

Section: Introductionmentioning

confidence: 99%

Fungal Iron Availability during Deep Seated Candidiasis Is Defined by a Complex Interplay Involving Systemic and Local Events

et al. 2013

View full text Add to dashboard Cite

Nutritional immunity – the withholding of nutrients by the host – has long been recognised as an important factor that shapes bacterial-host interactions. However, the dynamics of nutrient availability within local host niches during fungal infection are poorly defined. We have combined laser ablation-inductively coupled plasma mass spectrometry (LA-ICP MS), MALDI imaging and immunohistochemistry with microtranscriptomics to examine iron homeostasis in the host and pathogen in the murine model of systemic candidiasis. Dramatic changes in the renal iron landscape occur during disease progression. The infection perturbs global iron homeostasis in the host leading to iron accumulation in the renal medulla. Paradoxically, this is accompanied by nutritional immunity in the renal cortex as iron exclusion zones emerge locally around fungal lesions. These exclusion zones correlate with immune infiltrates and haem oxygenase 1-expressing host cells. This local nutritional immunity decreases iron availability, leading to a switch in iron acquisition mechanisms within mature fungal lesions, as revealed by laser capture microdissection and qRT-PCR analyses. Therefore, a complex interplay of systemic and local events influences iron homeostasis and pathogen-host dynamics during disease progression.

show abstract

“…Perhaps the most dramatic example is that of iron dextran-treated infants where the incidence of gramnegative sepsis was increased 20-fold by the treatment [21]. That observation has been challenged [22], but on reanalysis the original study remains convincing [23]. And recent publications continue to support the conclusion that there is a significant association between treated iron deficiency [24], excess total body iron [25,26], and increased susceptibility to infection.…”

Section: Discussionmentioning

confidence: 99%