Iron and Infection in the Newborn

Barry, David M.; Reeve, A. W.

doi:10.1016/s0140-6736(74)92256-9

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…Indeed if Fe-de®cient individuals who have compromised resistance to infection are given large doses of Fe parenterally or orally, an exacerbation of infection and death can occur (McFarlane et al 1970;Brock, 1993). Likewise, parenteral Fe administration to low birth weight babies increased the incidence of septicaemia (Barry & Reeve, 1974). Chilean children who received Fe-forti®ed milk (12 mg Fe=l) had a 20 % higher incidence of diarrhoea than those who received a control milk containing 1 mg Fe=l (Brunser et al 1993).…”

Section: Ironmentioning

confidence: 99%

Undernutrition, infection and immune function

2000

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Undernutrition and infection are the major causes of morbidity and mortality in the developing world. These two problems are interrelated. Undernutrition compromises barrier function, allowing easier access by pathogens, and compromises immune function, decreasing the ability of the host to eliminate pathogens once they enter the body. Thus, malnutrition predisposes to infections. Infections can alter nutritional status mediated by changes in dietary intake, absorption and nutrient requirements and losses of endogenous nutrients.

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Section: Ironmentioning

confidence: 99%

Undernutrition, infection and immune function

2000

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An other look at iron: Role in host pathogen interaction

Ganzoni

Puschmann

1975

Blut

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Iron, as participant of many biological processes is a prerequisite for life. Uptake, internal transport and storage by organisms is handled by highly specialized chemical systems endowed with strong metal binding affinities. Apart from the homeostatic function of iron-binding compounds they appear of significance for inter-species interactions. Thus, by tight binding transferrin withholds the iron from invading microorganisms required for their optimal growth. This bacteriostatic property of the iron transport protein is however partially overcome by small molecular substances synthesized by bacteria and successfully competing for the metal. The balance of such interaction is a complex one. Yet, strong evidence points to the crucial importance of the amount of iron offered by a host to infecting agents for determining the fate of bacterial disease.

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10 Iron and infection

Peto¹,

Hershko²

1989

Baillière's Clinical Haematology

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Iron and Infection in the Newborn

Cited by 4 publications

References 7 publications

Undernutrition, infection and immune function

Undernutrition, infection and immune function

An other look at iron: Role in host pathogen interaction

10 Iron and infection

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