Iron-based magnetic nanoparticles for magnetic resonance imaging

Fatima, Hira; Kim, Kyo‐Seon

doi:10.1016/j.apt.2018.07.017

Cited by 49 publications

(28 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The selected literature was classified into four main groups:Methods of synthesis of IONPs [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56]Characterization of IONPs [57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,…”

Section: Resultsmentioning

confidence: 99%

“…Methods of synthesis of IONPs [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56]…”

Section: Resultsmentioning

confidence: 99%

“…Through the co-precipitation synthesis, it is possible to obtain MNPs broadly distributed around a mean diameter value ranging from 5 to 40 nm (Table 1). More generally, size, shape, and magnetic properties of the resulting IONPs depend on reaction conditions such as the type of salts used [19], pH, and ionic strength [20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Flowchart for the synthesis of IONPs by co-precipitation [19]. In this example, Fe 3 O 4 NPs are prepared from a mixture of FeSO 4 and FeCl 3 in the molar ratio of 1:2.…”

Section: Figurementioning

confidence: 99%

See 3 more Smart Citations

Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

et al. 2019

View full text Add to dashboard Cite

Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomedical field. This review provides an up-to-date overview of the methods of synthesis and functionalization of MNPs focusing on Iron Oxide Nanoparticles (IONPs). Firstly, synthesis strategies for fabricating IONPs of different composition, sizes, shapes, and structures are outlined. We describe the close link between physicochemical properties and magnetic characterization, essential to developing innovative and powerful magnetic-driven nanocarriers. In conclusion, we provide a complete background of IONPs functionalization, safety, and applications for the treatment of Central Nervous System disorders.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Methods of synthesis of IONPs [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56]…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Flowchart for the synthesis of IONPs by co-precipitation [19]. In this example, Fe 3 O 4 NPs are prepared from a mixture of FeSO 4 and FeCl 3 in the molar ratio of 1:2.…”

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

et al. 2019

View full text Add to dashboard Cite

show abstract

“…MRI avoids the use of radiation and provides exhaustive anatomical information with high spatial and temporal resolution. MRI has a high capacity to detect soft tissues and in the clinical setting is employed, among others, for the detection of tumours and imaging of the nervous system [1,2,3,4]. The diagnostic value of MRI can be further expanded by using exogenous contrast agents that improve the resolution of the technique allowing a better interpretation of the acquired images.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI)

et al. 2019

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is a useful tool for disease diagnosis and treatment monitoring. Superparamagnetic iron oxide nanoparticles (SPION) show good performance as transverse relaxation (T2) contrast agents, thus facilitating the interpretation of the acquired images. Attachment of SPION onto nanocarriers prevents their agglomeration, improving the circulation time and efficiency. Graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (RGO), are appealing nanocarriers since they have both high surface area and functional moieties that make them ideal substrates for the attachment of nanoparticles. We have employed a fast, simple and environmentally friendly microwave-assisted approach for the synthesis of SPION-RGO hybrids. Different iron precursor/GO ratios were used leading to SPION, with a median diameter of 7.1 nm, homogeneously distributed along the RGO surface. Good relaxivity (r2*) values were obtained in MRI studies and no significant toxicity was detected within in vitro tests following GL261 glioma and J774 macrophage-like cells for 24 h with SPION-RGO, demonstrating the applicability of the hybrids as T2-weighted MRI contrast agents.

show abstract