Iron-catalysed sequential reaction towards α-aminonitriles from secondary amines, primary alcohols and trimethylsilyl cyanide

Abstract

We have developed a one-pot iron-catalysed sequential reaction of secondary amines with primary alcohols, trimethylsilyl cyanide and TBHP under mild reaction conditions to give the corresponding α-aminonitriles.

One‐Pot Synthesis of α‐Amino Nitrile Units through Alkylative Strecker Cyanation from Formamides

“…2‐(Methyl(phenyl)amino)propanenitrile (33) : [25] Obtained as yellow oil (m=81.2 mg, 41 % yield). Purification by flash chromatography (Diethyl ether/Pentane: 2/98).…”

An efficient approach for the synthesis of novel methyl sulfones in acetic acid medium and evaluation of antimicrobial activity

“…The alcohol functional group is one of the more important groups for the synthesis of many drugs which are being used widely throughout the world [1][2][3][4][5]. As the alcohol functional group is not a good leaving group, it becomes the main obstacle for producing versatile novel drugs in organic synthesis.…”

Magnetically separable g‐C3N4 hybrid nanocomposite: Highly efficient and eco‐friendly recyclable catalyst for one‐pot synthesis of α‐aminonitriles

“…Application of trimethylsilylcyanide (TMSCN), which is relatively easy to handle and highly soluble in organic solvents, instead of KCN and HCN as a cyanoanion source provides promising and safer routes to α‐aminonitriles . These limitations and the importance of this reaction in organic synthesis have attracted many chemists to focus on the design of suitable and new catalysts that work under mild and green conditions . Although some of these methods are satisfactory, some of these reported methods involve the use of expensive reagents, hazardous solvents, longer reaction times and tedious work‐up procedures.…”