Iron-catalyzed regioselective protoboration of alkenes on N-heterocycles

Zou, Chenchen; Zhang, Chun

doi:10.1039/d2qo01293f

Org. Chem. Front.

2022

DOI: 10.1039/d2qo01293f

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Iron-catalyzed regioselective protoboration of alkenes on N-heterocycles

Chenchen Zou

Chun Zhang

Abstract: A novel iron-catalyzed highly regioselective protoboration of alkene on N-heterocycles, which are important core in a variety of pharmaceutical compounds, has been developed. Under practical reaction conditions, a series of...

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2024

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Iron‐Catalyzed Regioselective Borobenzylation of Vinyl Arenes

Meng,

Yun

2024

Adv Synth Catal

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Herein, catalytic difunctionalization of vinyl arenes is reported using iron salt as a catalyst without ligands. A series of substituted alkylboronic acid esters was obtained as a single regioisomer from vinyl arenes at 50 °C. This multicomponent protocol enabled the formation of C–C and C–B bonds to produce boroalkylated products in a single process. A non‐radical pathway is proposed for the reaction in contrast to the radical pathways of iron‐catalyzed hydroalkylation reactions. The organoboron compounds generated from this reaction were further utilized for diverse functional group conversions.

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Iron‐Catalyzed Regioselective Borobenzylation of Vinyl Arenes

Meng,

Yun

2024

Adv Synth Catal

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Iron-catalyzed regioselective protoboration of alkenes on N-heterocycles

Abstract: A novel iron-catalyzed highly regioselective protoboration of alkene on N-heterocycles, which are important core in a variety of pharmaceutical compounds, has been developed. Under practical reaction conditions, a series of...

Cited by 1 publication

References 59 publications

Iron‐Catalyzed Regioselective Borobenzylation of Vinyl Arenes

Iron‐Catalyzed Regioselective Borobenzylation of Vinyl Arenes

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