Iron-catalyzed thioetherification of thiols with aryl iodides

Abstract

FeCl(3) in combination with bisphosphine ligands represents an efficient catalyst system for the cross-coupling of aryl- and alkyl thiols with aryl iodides, a broad spectrum of functional groups can be tolerated during the catalysis.

Iron Catalysis in Organic Synthesis

“…613 They employed iron(III) chloride as catalyst but replaced the DMEDA ligand by Xantphos. Thus, a number of alkyl aryl thioethers could be obtained in high yields.…”

Metal Acetylacetonates Covalently Anchored onto Amine Functionalized Silica/Starch Composite for the One-Pot Thioetherification and Synthesis of 2H-Indazoles

“…The preparation of thioethers has been under consideration and widely studied in recent years using palladium [23], nickel [24], cobalt [25], copper [26] and iron salts [27] as catalysts. Migita et al [28] first reported the coupling of aryl halides with thiols using Pd(PPh 3 ) 4 as a catalyst.…”

An efficient iron-catalyzed S-arylation of aryl and alkylthiols with aryl halides in the presence of water under aerobic conditions

“…12 Moreover, in most cases, the catalytic systems comprised of expensive catalysts, phosphine-based ligands, moisture sensitive bases, and organic solvents. 13 On the other hand, in recent years the design of green chemistry approaches for the thiol S-arylation reactions has received much attention. The use of water as a solvent for organic reactions is of high practical value, since water is cheap, non-toxic, safe, and environmentally benign as compared to organic solvents.…”