Iron Chelation by Chlorogenic Acid as a Natural Antioxidant

Kono, Yasuhisa; Kashine, Sakiko; Yoneyama, Takushi; Sakamoto, Yuji; Matsui, Yoshihisa; Shibata, Hitoshi

doi:10.1271/bbb.62.22

Cited by 126 publications

(80 citation statements)

References 13 publications

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“…Many phenolic compounds have been isolated from vegetables, and their antioxidant activity has been evaluated by several researchers (Tsushida et al, 1994;Maruta et al, 1995;Price et al, 1998). Chlorogenic acid was found as the antioxidant in burdock (Maruta et al, 1995) and eggplant (Winter & Herrmann, 1986), and was reported to have a strong radical-scavenging activity on DPPH radical (Kono et al, 1998). Therefore, the higher activity of burdock and eggplant is probably derived from chlorogenic acid.…”

Section: Resultsmentioning

confidence: 99%

Radical-Scavenging Activity of Vegetables and the Effect of Coking on Their Activity.

Yamaguchi

Mizobuchi

Kajikawa

et al. 2001

FSTR

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The radical-scavenging activity of vegetables was measured using the 1,1-diphenyl-2-picrylhydrazyl-HPLC method, and the effect of cooking on this activity was determined. The content of ascorbic acid having radical-scavenging activity was highest in burdock among the 18 fresh vegetables tested. In some vegetables, the activity increased in spite of the loss of ascorbic acid content after boiling, while in other vegetables, the activity had decreased after boiling. This decrease may be due to release of the activity from cooked tissue into the cooking water during boiling. Both activity and ascorbic acid content of the vegetables cooked in a microwave were generally higher than in those cooked by boiling.

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Section: Resultsmentioning

confidence: 99%

Radical-Scavenging Activity of Vegetables and the Effect of Coking on Their Activity.

Yamaguchi

Mizobuchi

Kajikawa

et al. 2001

FSTR

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“…NaChl has no effect on some known kinases including several members of the Src-kinase family (Lyn, HCK, Fyn), JAK-kinases (JAK2, JAK3), and serine kinases (PKC␣, PKC␤II/␦). Chlorogenic acid has diverse biologic activities including anti-HIV activity, 44 antioxidant activity, 45 anticarcinogenic activity, 46 modulating activity of cytochrome P450-linked enzyme, 47 antiallergic activity, 48 and apoptosis-inducing activity in human oral squamous cell carcinoma For personal use only. on May 11, 2018.…”

Section: Discussionmentioning

confidence: 99%

Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase–dependent apoptosis in chronic myelogenous leukemic cells

Bandyopadhyay

Biswas

Roy

et al. 2004

Blood

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We report that chlorogenic acid (Chl) induces apoptosis of several Bcr-Ablpositive chronic myelogenous leukemia (CML) cell lines and primary cells from CML patients in vitro and destroys BcrAbl-positive K562 cells in vivo. In contrast, this compound has no effect on the growth and viability of Bcr-Abl-negative lymphocytic and myeloid cell lines and primary CML cells. Sodium chlorogenate (NaChl) exhibits 2-fold higher efficiency in killing K562 cells compared with Chl. NaChl also induces growth inhibition of squamous cell carcinoma (HSC-2) and salivary gland tumor cells (HSG), although at 50-fold higher concentration. NaChl inhibits autophosphorylation of p210 Bcr-Abl fusion protein rapidly. We demonstrate that p38 phosphorylation is increased in Bcr-Abl-positive cells after treatment with NaChl and closely paralleled the inhibition of Bcr-Abl phosphorylation. NaChl did not increase phosphorylation of p38 in Bcr-Abl-negative cells including HSC-2 and HSG that are responsive to this compound, indicating that p38 activation by NaChl is dependent on Bcr-Abl kinase inhibition. Inhibition of p38 activity by SB203580 significantly reduced NaChl-induced apoptosis of K562 cells, whereas activation of p38 by anisomycin augmented the apoptosis. These findings indicate that inhibition of BcrAbl kinase leading to activation of p38 mitogen-activated protein ( IntroductionChronic myelogenous leukemia (CML) is a malignant clonal disorder of hematopoietic stem cells leading to massive expansion of myeloid lineage cells. 1 The natural fate of CML is to progress from a benign chronic phase into the fatal blast crisis between approximately 3 and 5 years. Development of CML is associated with a specific chromosomal translocation known as the Philadelphia (Ph) chromosome that is detectable throughout the course of the disease. 2 Somatic mutation in Ph chromosome originates from reciprocal translocation between the long arms of chromosomes 9 and 22 and fuses Bcr with c-Abl genetic sequences. Both the Bcr-Abl fusion proteins p210 and p185 can cause CML or acute leukemia. 3,4 The p210 form of Bcr-Abl is seen in 95% of CML and in 20% of acute lymphocytic leukemia, whereas the p185 form is identified in about 10% of acute lymphocytic leukemia patients. 5,6 The Bcr-Abl fusion proteins are constitutively active non-receptor tyrosine kinases whose activity is essential for transforming abilities. 7 An almost universal presence of Bcr-Abl in CML patients made this fusion protein an attractive target for drug development. Bcr-Abl inhibitors, STI571, adaphostin, and PD173955, are capable of inducing a variable degree of apoptosis in human CML cells. [8][9][10] The signal transduction pathways involved in mediating apoptosis by Bcr-Abl inhibitors are poorly defined. In the current study, we describe a novel Bcr-Abl kinase inhibitor that triggers p38 mitogen-activated protein (MAP) kinase-dependent apoptosis of Bcr-Abl-positive CML cells. Materials and methods Cells and reagentsThe Ph chromosome ϩ CML cell line K562, 11 Ph chromosome-negative T-...

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“…This avoids the access of H 2 O 2 to the coordination sphere. Thus the Fenton reaction is inhibit (70) . The complete Fe 3+ chelation is improved at high pH values.…”

Section: Ligands Effects On Fenton Reactionmentioning

confidence: 99%

Fenton Reaction Driven by Iron Ligands

Salgado

Melín

Contreras

et al. 2013

J. Chil. Chem. Soc.

107

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One of the most important sources of reactive oxygen species (ROS) in biological systems is the Fenton reaction. In this, the Fe 2+ or Fe 3+ reacts with H 2 O 2 to produce ROS as the hydroxyl radical (•OH), superoxide radical (O 2 •-) and singlet oxygen ( 1 O 2 ). The main ROS, responsible for the high oxidizing power of the Fenton reaction, is not clear. Some authors claim that the principal reactive species is •OH, while others propose a ferryl specie (Fe 4+ or [FeO] 2+ ) (1,2) . Recently, have been proposed that the kind of reaction species produced depends mainly of pH and the iron composition of the coordination sphere. This is highlighted for Fe 3+ , because in mono and (some) bis-complexes Fe 3+ is reduced to Fe 2+ and there are some positions occupied by water or hydroxide ligands, readily to be exchanged by H 2 O 2 . On the other hand, in tris-complexes there are not any positions occupied by water or hydroxide, avoiding the formation of peroxo-complexes, necessary for Fenton or Fenton like reaction.The 1,2-dihydroxybenzenes (DHBs) have been described as modulators of Fenton reaction. The DHBs driven Fenton reaction have been used for environmental applications as an advanced oxidation process. Furthermore, these systems participate in different biological process, as the wood biodegradation by fungi and oxidative stress in neurodegenerative diseases.In this review, the effect of 1,2-dihydroxybenzenes on the activated species production by the Fenton and Fenton like reaction will be discussed and its participation in different systems.

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Iron Chelation by Chlorogenic Acid as a Natural Antioxidant

Cited by 126 publications

References 13 publications

Radical-Scavenging Activity of Vegetables and the Effect of Coking on Their Activity.

Radical-Scavenging Activity of Vegetables and the Effect of Coking on Their Activity.

Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase–dependent apoptosis in chronic myelogenous leukemic cells

Fenton Reaction Driven by Iron Ligands

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