Iron-Cobalt Ferrite Nanoparticles—Biocompatibility and Distribution After Intravenous Administration to Rat

Laznev, K. V.; Tzerkovsky, D. A.; Kekalo, Katsiaryna; Жавнерко, Г. К.; Agabekov, V. E.

doi:10.1109/tmag.2012.2222020

Cited by 9 publications

(2 citation statements)

References 16 publications

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“…Most of the studies are devoted to the cobalt ferrite MNPs biocompatibility investigation after i.v. administration [ 19 , 32 ]. However, the used concentrations of MNPs are often not sufficient to achieve the required temperatures for MHT.…”

Section: Discussionmentioning

confidence: 99%

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

et al. 2021

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Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the biocompatibility of 12 nm cobalt ferrite MNPs, functionalized with citrate ions, in different dosages on mice and rats of both sexes was investigated for 30 days after intraperitoneal injection. The animals’ weight, behavior, and blood cells changes, as well as blood biochemical parameters are correlated to histological examination of organs revealing that cobalt ferrite MNPs do not have toxic effects at concentrations close to those used previously for efficient MHT. Moreover, these MNPs demonstrated high specific loss power (SLP) of about 400 W g−1. Importantly the MNPs retained their magnetic properties inside tumor tissue after intratumoral administration for several MHT cycles within three days. Thus, cobalt ferrite MNPs represent a perspective platform for tumor therapy by MHT due to their ability to provide effective heating without exerting a toxic effect on the organism. This opens up new avenues for smaller MNPs sizes while their heating efficiency is maintained.

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Section: Discussionmentioning

confidence: 99%

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

et al. 2021

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“…to the surface [15,16]. A study by Laznev et al revealed that, there were no significant difference in the cytotoxicity of CoFe 2 O 4 and polysiloxane surface coated CoFe 2 O 4 nanoparticles [17]. CoFe 2 O 4 nanoparticles were also revealed as promising nanocarriers in controlled drug delivery applications [18].…”

Section: Introductionmentioning

confidence: 99%