Iron complexes of dietary flavonoids: Combined spectroscopic and mechanistic study of their free radical scavenging activity

Marković, Jasmina M. Dimitrić; Marković, Zoran; Brdarić, Tanja P.; Pavelkić, Vesna; Jadranin, Milka

doi:10.1016/j.foodchem.2011.06.008

Cited by 51 publications

(30 citation statements)

References 30 publications

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“…Either hydroxyls at 5- and 6- carbon atoms or 6-hydroxyl-7-hydroxyl are potentially the binding sites of Fe 2+ and Fe 3+ ions, with a 1:1 and 1:2 stoichiometry. The Fe-bicalein complexes have high antioxidant properties due to inhibition of the Fenton reaction [ 152 , 153 ]. Similarly, two potential bidentate binding sites are present in the luteolin structure (5-hydroxyl-4-carbonyl and 3′4′-hydroxyl groups of the ring B) and both sites can bind Al 3+ ions in the molar ratio 2:1 (metal:ligand).…”

Section: Flavonoids Are the Major Contributors Of Green Synthesis mentioning

confidence: 99%

Secondary Metabolites in the Green Synthesis of Metallic Nanoparticles

Marslin¹,

et al. 2018

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The ability of organisms and organic compounds to reduce metal ions and stabilize them into nanoparticles (NPs) forms the basis of green synthesis. To date, synthesis of NPs from various metal ions using a diverse array of plant extracts has been reported. However, a clear understanding of the mechanism of green synthesis of NPs is lacking. Although most studies have neglected to analyze the green-synthesized NPs (GNPs) for the presence of compounds derived from the extract, several studies have demonstrated the conjugation of sugars, secondary metabolites, and proteins in these biogenic NPs. Despite several reports on the bioactivities (antimicrobial, antioxidant, cytotoxic, catalytic, etc.) of GNPs, only a handful of studies have compared these activities with their chemically synthesized counterparts. These comparisons have demonstrated that GNPs possess better bioactivities than NPs synthesized by other methods, which might be attributed to the presence of plant-derived compounds in these NPs. The ability of NPs to bind with organic compounds to form a stable complex has huge potential in the harvesting of precious molecules and for drug discovery, if harnessed meticulously. A thorough understanding of the mechanisms of green synthesis and high-throughput screening of stabilizing/capping agents on the physico-chemical properties of GNPs is warranted to realize the full potential of green nanotechnology.

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Section: Flavonoids Are the Major Contributors Of Green Synthesis mentioning

confidence: 99%

Secondary Metabolites in the Green Synthesis of Metallic Nanoparticles

Marslin¹,

et al. 2018

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“…The distinct pathways by which flavonoid molecules (ArOH) transfer their charge provide several mechanisms of their antioxidant action. The representative one leads to the direct O-H bond breaking and proceeds by rapid donation of the proton and electron to a radical form (ArOH+HO•→ArO•+HOH), while the second one assumes indirect H atom abstraction (ArOH+HO•→ArOH + +OH•→ArO•+HOH) (Marković et al ., 2011). Baicalein has O-H bonds, and can scavenge radical by O-H bonds.…”

Section: Discussionmentioning

confidence: 99%

Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress

Piao

Fernando

et al. 2016

Biomolecules & Therapeutics

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Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) radiation in a human keratinocyte cell line (HaCaT). Baicalein absorbed light within the wavelength range of UVB. In addition, baicalein decreased the level of intracellular reactive oxygen species (ROS) in response to UVB radiation. Baicalein protected cells against UVB radiation-induced DNA breaks, 8-isoprostane generation and protein modification in HaCaT cells. Furthermore, baicalein suppressed the apoptotic cell death by UVB radiation. These findings suggest that baicalein protected HaCaT cells against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging ROS.

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“…Moderate decreases in the radical scavenging of HKaem are observed by Sn(CH 3 COO) 2 coordination and by contact between Sn and HKaem, in agreement with the increase in the oxidation potential of the complex compared to HKaem, leading to a decrease in antioxidant efficiency for fruits and vegetables with Sn as package materials. be increased by the presence of copper (II), iron (III), and zinc (II) by other authors and our recent studies [7,8,[23][24][25][26]. In the present study, HKaem was selected as a typical flavonoid with two possible chelation sites (3,4 and 4,5) for metal ions, and complex formation by Sn(II) coordination to HKaem was investigated together with the complex as a radical scavenger.…”

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confidence: 87%

Kinetic Studies on Radical Scavenging Activity of Kaempferol Decreased by Sn(II) Binding

Yang

Qian

et al. 2020

Molecules

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Sn(II) binds to kaempferol (HKaem, 3,4 ,5,7-tetrahydroxy-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one) at the 3,4-site forming [Sn(II)(Kaem) 2 ] complex in ethanol. DPPH • scavenging efficiency of HKaem is dramatically decreased by SnCl 2 coordination due to formation of acid inhibiting deprotonation of HKaem as ligands and thus reduces the radical scavenging activity of the complex via a sequential proton-loss electron transfer (SPLET) mechanism. Moderate decreases in the radical scavenging of HKaem are observed by Sn(CH 3 COO) 2 coordination and by contact between Sn and HKaem, in agreement with the increase in the oxidation potential of the complex compared to HKaem, leading to a decrease in antioxidant efficiency for fruits and vegetables with Sn as package materials. be increased by the presence of copper (II), iron (III), and zinc (II) by other authors and our recent studies [7,8,[23][24][25][26]. In the present study, HKaem was selected as a typical flavonoid with two possible chelation sites (3,4 and 4,5) for metal ions, and complex formation by Sn(II) coordination to HKaem was investigated together with the complex as a radical scavenger. The effect on radical scavenging efficiency of HKaem by Sn(II) coordination is of relevance as Sn is used for packaging of food, and accordingly deserves more attention.Molecules 2020, 25, x FOR PEER REVIEW

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Iron complexes of dietary flavonoids: Combined spectroscopic and mechanistic study of their free radical scavenging activity

Cited by 51 publications

References 30 publications

Secondary Metabolites in the Green Synthesis of Metallic Nanoparticles

Secondary Metabolites in the Green Synthesis of Metallic Nanoparticles

Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress

Kinetic Studies on Radical Scavenging Activity of Kaempferol Decreased by Sn(II) Binding

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