Iron Deficiency Alters DMBA-Induced Tumor Burden and Natural Killer Cell Cytotoxicity in Rats

Spear, Amanda T.; Sherman, Adria Rothman

doi:10.1093/jn/122.1.46

Cited by 54 publications

(39 citation statements)

References 28 publications

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“…These results suggested that iron deficiency leads to impaired T-cell response. Another study showed that NK cell cytotoxicity was impaired in rats fed an iron-deficient diet, and adding IFN-g in vitro rescued the loss of function (42).…”

Section: Current Status Of Knowledgementioning

confidence: 99%

Iron Biology, Immunology, Aging, and Obesity: Four Fields Connected by the Small Peptide Hormone Hepcidin

Dao

Meydani

2013

Advances in Nutrition

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Iron status and immune response become impaired in situations that involve chronic inflammation, such as obesity or aging. Little is known, however, about the additional burden that obesity may place on the iron status and immune response in the elderly. This question is relevant given the rising numbers of elderly obese (BMI >30 kg/m 2 ) individuals and the high prevalence of iron deficiency worldwide. Iron is necessary for proper function of both the innate and adaptive immune system. Hepcidin, a peptide hormone that regulates cellular iron export, is essential for the maintenance of iron homeostasis. Therefore, since immune cells require iron for proper function hepcidin may also play an important role in immune response. In this review, we summarize the evidence for hepcidin as a link between the fields of gerontology, obesity, iron biology, and immunology. We also identify several gaps in knowledge and unanswered questions pertaining to iron homeostasis and immunity in obese populations. Finally, we review studies that have shown the impact of weight loss, focusing on calorie restriction, iron homeostasis, and immunity. These studies are important both in elucidating mechanistic links between obesity and health impairments and identifying possible approaches to target immune impairment and iron deficiency as comorbidities of obesity.

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Section: Current Status Of Knowledgementioning

confidence: 99%

Iron Biology, Immunology, Aging, and Obesity: Four Fields Connected by the Small Peptide Hormone Hepcidin

Dao

Meydani

2013

Advances in Nutrition

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“…Macrophage phagocytosis is generally unaffected by iron defi ciency, but bactericidal activity of these macrophages is shown to be attenuated in some studies. Neutrophils have a reduced activity of myeloperoxidase, an iron-containing enzyme, which produces reactive oxygen intermediates responsible for intercellular killing of pathogens [6]. Moreover, in vitro studies have shown that there is a direct link between iron defi ciency and impaired T-lymphocyte proliferation.…”

Section: Introductionmentioning

confidence: 99%

Effect of iron deficiency anemia and its treatment on cell mediated immunity

Attia¹,

Essa²,

Nosair³

et al. 2009

Indian J Hematol Blood Transfus

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Iron defi ciency anemia (IDA) is one of the most prevalent micronutrient defi ciencies particularly in the developing countries. While there is evidence of an altered immune profi le in iron defi ciency, the exact immunoregulatory role of iron is not known. Knowledge particularly in children, who are vulnerable to iron defi ciency and infection, is lacking. We aimed to study the effects of IDA and its treatment with oral iron supplementation on cell-mediated immunity. The levels of T-lymphocytes, their CD4 + , CD8 + and CD1a + subsets, transferrin receptor (CD71) and serum ferritin were evaluated in 40 iron-defi cient and 40 healthy children. The impact of oral iron supplementation for three months on the same parameters was also noted in children with IDA. The level of mature T-lymphocytes (CD4 + and CD8 + ) was signifi cantly lower (P<0.001) while that of the immature T-cells (CD1a + ) was signifi cantly higher (p<0.001) in IDA children compared to the control. The mature T-cell count was signifi cantly improved after iron therapy. In spite of signifi cant reduction in the immature T-cells (CD1a+) level after iron supplementation, it was signifi cantly higher than the control. The present study demonstrated that T-lymphocytes maturation was defective in IDA and improved partially after 3 months of iron supplementation. Therefore, longer time of iron therapy may be required to induce complete maturation of T-lymphocytes.

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“…Neutrophils have a reduced activity of myeloperoxidase, an iron-containing enzyme which produces reactive oxygen intermediates (ROI) that are responsible for intracellular killing of pathogens. 13 In vitro studies have shown that there is a direct correlation between iron deficiency and impaired T-lymphocyte proliferation. There is a decrease in T-lymphocyte blastogenesis and mitogenesis in response to a number of different mitogens.…”

Section: Discussionmentioning

confidence: 99%

CD4+ T lymphocytopenia associated with sideropenia: case report

Vito¹,

Ribeiro²,

Silva

et al. 2017

Medicina (Ribeirão Preto)

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Importance of the issue: Idiopathic CD4 T lymphocytopenia is an unusual immune defect in which there is an unexplained deficit of CD4 T cells. This case presents a 39-year-old female patient, with CD4+ T lymphocytopenia, who was not infected with immunosuppressive viruses neither was she subjected to immunosuppressive therapies. Comments: While monitoring the patient, she was found to have very low serum ferritin and, after parenteral iron therapy, there were changes in CD4+ cell levels, indicating that, in this case, lymphocytopenia was secondary to sideropenia. The patient is being kept under strict control of serum iron and periodic immunological evaluation, and she has not showed any clinical and/or laboratory adverse events so far. It is known that iron deficiency is an important factor in the genesis of immunological changes that occur in patients with iron deficiency anemia. It is important to understand the effects of iron deficiency on the immune system due to its high prevalence worldwide. Moreover, it could also help to clarify several cases of idiopathic CD4 lymphocytopenia.Keywords: T-Lymphocytopenia, Idiopathic CD4-Positive. Iron Deficiency. Case Reports. RESUMOImportância da questão: Linfocitopenia T CD4+ idiopática é um defeito imune incomum em que há um déficit inexplicável de células T CD4. Este caso clínico apresenta uma paciente do sexo feminino de 39 anos de idade, com linfocitopenia T CD4+, que não estava infectada por vírus imunossupressores nem foi submetida a terapias imunossupressoras. Comentários: Durante o acompanhamento da paciente, ela apresentou níveis muito baixos de ferritina sérica e, após a terapia parenteral de ferro, houve aumento da quantidade de células CD4+, indicando que, neste caso, linfocitopenia era secundária à sideropenia. A paciente estava sendo mantida sob rigoroso controle de ferro sérico e avaliação imunológica periódica, e não mostrou quaisquer eventos adversos clínicos e/ou laboratoriais até o momento. Com base em mudanças na reatividade imunológica dos pacientes observadas por outros pesquisadores após a suplementação com ferro, é evidente que a deficiência de ferro seria um fator importante na gênese das alterações imunológicas que ocorrem em pacientes com anemia ferropriva. É importante compreender os efeitos da deficiência de ferro no sistema imune, devido à sua elevada prevalência mundial. Essas informações também auxiliariam a esclarecer vários casos de linfocitopenia T CD4+ idiopática.

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Iron Deficiency Alters DMBA-Induced Tumor Burden and Natural Killer Cell Cytotoxicity in Rats

Cited by 54 publications

References 28 publications

Iron Biology, Immunology, Aging, and Obesity: Four Fields Connected by the Small Peptide Hormone Hepcidin

Iron Biology, Immunology, Aging, and Obesity: Four Fields Connected by the Small Peptide Hormone Hepcidin

Effect of iron deficiency anemia and its treatment on cell mediated immunity

CD4+ T lymphocytopenia associated with sideropenia: case report

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