Iron Deficiency and Glycosylated Hæmoglobin A1

Brooks, Andrew Pattrick; Metcalfe, J.; Day, J. L.; Edwards, Margot

doi:10.1016/s0140-6736(80)90019-7

Cited by 147 publications

(119 citation statements)

References 2 publications

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“…Iron deficiency anemia is a commonly reported condition associated with falsely elevated A1c. Studies in patients with and without diabetes have demonstrated that treatment of iron deficiency anemia lowers A1c, [16][17][18] although the exact mechanism remains unclear. 19 Other conditions associated with decreased red cell turnover are also associated with falsely elevated A1c including vitamin B-12 and folate deficiency anemias, and asplenia.…”

Section: Falsely Elevated A1cmentioning

confidence: 99%

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

2013

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Section: Falsely Elevated A1cmentioning

confidence: 99%

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

2013

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“…This is the case of troubles of iron metabolism [117,118] , e.g., in HIV infection [119] even in non-diabetic subjects [120] . In all occurrences, the importance of taking into account within-subject biological variations in both type 1 [121] and type 2 [122] diabetic patients and in non-diabetic subjects [123] for clinical interpretation was underlined.…”

Section: The Times Of Expansionmentioning

confidence: 99%

A history of HbA_1c through Clinical Chemistry and Laboratory Medicine

Gillery¹

2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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HbA 1c was discovered in the late 1960s and its use as marker of glycemic control has gradually increased over the course of the last four decades. Recognized as the gold standard of diabetic survey, this parameter was successfully implemented in clinical practice in the 1970s and 1980s and internationally standardized in the 1990s and 2000s. The use of standardized and well-controlled methods, with well-defined performance criteria, has recently opened new directions for HbA 1c use in patient care, e.g., for diabetes diagnosis. Many reports devoted to HbA 1c have been published in Clinical Chemistry and Laboratory Medicine (CCLM) journal. This review reminds the major steps of HbA 1c history, with a special emphasis on the contribution of CCLM in this field.

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“…It was proposed that, in iron deficiency, the quanternary structure of the haemoglobin molecule was altered, and that glycation of the globin chain occurred more readily in the relative absence of iron. 13 Sluiter et al tried to provide an explanation for the above findings. They proposed that the formation of glycatedhaemoglobin is an irreversible process and hence, the concentration of HbA1c in erythrocyte will increase linearly with the cells age.…”

Section: Discussionmentioning

confidence: 99%

“…They observed that HbA1c levels were significantly higher in iron deficiency anaemia patients and decreased after treatment with iron. 13 Sluiter et al proposed that the formation of glycatedhaemoglobin is an irreversible process and hence, the concentration of HbA1c in erythrocyte will increase linearly with the cells age. They found that in patients with normal blood glucose levels, but with very young red cells, as would be found after treatment of iron deficiency anaemia, HbA1c concentration was reduced.…”

Section: Introductionmentioning

confidence: 99%

Change in HbA1c Level with treatment of iron deficiency anaemia in non diabetic patients

Neki¹,

Meena²,

Singh³

et al. 2017

Int. J. Curr. Res. Biol. Med.

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Introduction:-Glycatedhaemoglobin(HbA1c) is used as an indicator of a patient's glycemic status over the previous 2-3 months. According to American Diabetes Association (ADA) Guidelines, HbA1c levels should be maintained below 7% in all diabetic patients in order to prevent the development of microvascular complications. Aims:-To study the effect of iron deficiency anaemia treatment on HbA1c level and to assess whether iron deficiency anaemia affects HbA1c levels. Material and Methods: 50 non-diabetic with confirmed iron deficiency anaemia (IDA) patients and 50 age-matched healthy subjects were enrolled in this study. Results: The mean baseline HbA1c level in the patients with IDA (6.12+0.21%) was significantly higher than controls groups(6.12+0.21%). After treatment of iron deficiency anaemia the mean HbA1c levels, significantly decreased from 6.12+0.21% to 5.21+0.16%. Conclusions: iron deficiency anaemia was associated with higher levels of HbA1c, which could cause problems in the diagnosis of uncontrolled diabetes mellitus in iron deficient patients.

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Iron Deficiency and Glycosylated Hæmoglobin A1

Cited by 147 publications

References 2 publications

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

A history of HbA_1c through Clinical Chemistry and Laboratory Medicine

Change in HbA1c Level with treatment of iron deficiency anaemia in non diabetic patients

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Iron Deficiency and Glycosylated Hæmoglobin A1

Cited by 147 publications

References 2 publications

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

A history of HbA1c through Clinical Chemistry and Laboratory Medicine

Change in HbA1c Level with treatment of iron deficiency anaemia in non diabetic patients

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Product

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A history of HbA_1c through Clinical Chemistry and Laboratory Medicine