Iron Deficiency Anemia☆

Dumitrascu, Catalina I.; Silberstein, Peter T.

doi:10.1016/b978-0-12-801238-3.05104-7

Cited by 1 publication

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References 5 publications

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“…It is also characterized by decreased ferritin, and MCV, while total iron-binding capacity and red blood cell distribution are increased. Hypochromic red blood cells can be also be observed by visual inspection on a blood smear ( Wagley, 1953 ; DeLoughery, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

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Blood Rheological Characterization of β-Thalassemia Trait and Iron Deficiency Anemia Using Front Microrheometry

et al. 2021

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The purpose of this work is to develop a hematocrit-independent method for the detection of beta-thalassemia trait (β-TT) and iron deficiency anemia (IDA), through the rheological characterization of whole blood samples from different donors. The results obtained herein are the basis for the development of a front microrheometry point-of-care device for the diagnosis and clinical follow-up of β-TT patients suffering hematological diseases and alterations in the morphology of the red blood cell (RBC). The viscosity is calculated as a function of the mean front velocity by detecting the sample fluid-air interface advancing through a microfluidic channel. Different viscosity curves are obtained for healthy donors, β-TT and IDA samples. A mathematical model is introduced to compare samples of distinct hematocrit, classifying the viscosity curve patterns with respect to the health condition of blood. The viscosity of the fluid at certain shear rate values varies depending on several RBC factors such as shape and size, hemoglobin (Hb) content, membrane rigidity and hematocrit concentration. Blood and plasma from healthy donors are used as reference. To validate their potential clinical value as a diagnostic tool, the viscosity results are compared to those obtained by the gold-standard method for RBC deformability evaluation, the Laser-Optical Rotational Red Cell Analyzer (LoRRCA).

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Section: Resultsmentioning

confidence: 99%

“…Hypochromic red blood cells can be also be observed by visual inspection on a blood smear (Wagley, 1953;DeLoughery, 2017).…”

Section: Comparison Of Blood Samples With Microcytic Red Blood Cells: Iron Deficiency Anemia and Beta-thalassemia Traitmentioning

confidence: 99%

Blood Rheological Characterization of β-Thalassemia Trait and Iron Deficiency Anemia Using Front Microrheometry

et al. 2021

View full text Add to dashboard Cite

show abstract

Iron Deficiency Anemia☆

Cited by 1 publication

References 5 publications

Blood Rheological Characterization of β-Thalassemia Trait and Iron Deficiency Anemia Using Front Microrheometry

Blood Rheological Characterization of β-Thalassemia Trait and Iron Deficiency Anemia Using Front Microrheometry

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