Iron deficiency anemia in children with cyanotic congenital heart disease and effect on cyanotic spells

Mukherjee, Satyam; Sharma, Monika; Devgan, Amit; Jatana, SK

doi:10.1016/j.mjafi.2017.07.003

Cited by 17 publications

(24 citation statements)

References 20 publications

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“…There is a paucity of literature discussing iron deficiency among children with CCHD and these studies have shown varying results. Our result is similar to prevalence rate found by Mukherjee S et al 16 In 1990, West et al, have demonstrated than more than one-third of patients with CCHD had iron deficiency. 17 In another study done by Olcay L et al, the prevalence of IDA was found to be 52.2%.…”

Section: Resultssupporting

confidence: 93%

“…4 In the study conducted by Mukerjee S et al, the frequency of cyanotic spells in the iron deficient group was 25% and association between iron deficiency anemia and cyanotic spells were found to be statistically significant (p value-0.042). 16 Children with IDA had eight times the risk of having cyanotic spells compared to the children who were not iron deficient highlighting the need of iron supplementation in children with cyanotic CHD…”

Section: Resultsmentioning

confidence: 99%

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Prevalence, profile of malnutrition and iron deficiency anemia in children with cyanotic congenital heart defects: a case control observational study in a tertiary care hospital in North India

Mir

Shah

Mushtaq

et al. 2019

Int J Contemp Pediatr

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Background: Children with congenital heart disease (CHD) are prone to malnutrition. Children with cyanotic CHD [CCHD] are specifically affected due to chronic hypoxia and iron deficiency anemia which is overlooked by pediatrician. This can have a significant effect on the outcome of surgery. Our objective was to determine the burden and determinant of malnutrition in children with several types of cyanotic congenital heart disease (CCHD).Methods: This case-control study included 80 children with symptomatic CCHD, and 40 healthy children matched for age and sex as a control group. Clinical evaluation and laboratory assessment of nutritional status were documented. Anthropometric measurements were recorded and Z scores for weight for age (WAZ), weight for height (WHZ), and height for age (HAZ) have been calculated. Haemoglobin, red cell indices and serum iron, total iron binding capacity and serum ferritin was done in cases and controls.Results: The overall prevalence of malnutrition was 72.5% in patients with CCHD and 22.5% in controls. Severe malnutrition was diagnosed in 68.9% of cases. All anthropometric measurements which markers of nutritional state are were significantly lower in the patients group compared to controls. The prevalence of iron deficiency anemia (IDA) was 47.5% in the study population. The study also showed that hemoglobin and hematocrit levels, RBC count were paradoxically higher in the cyanotic CHD as compared to the healthy controls though the iron studies revealed the iron deﬁciency. The mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) mean corpuscular hemoglobin concentration (MCHC), serum ferritin, serum iron, total iron binding capacity (TIBC), values were the parameters, which were found to be statistically signiﬁcant to differentiate the study groups.Conclusions: Malnutrition is a very common problem in children with symptomatic CCHD, the prevalence of IDA in children with CCHD was found to be high.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Prevalence, profile of malnutrition and iron deficiency anemia in children with cyanotic congenital heart defects: a case control observational study in a tertiary care hospital in North India

Mir

Shah

Mushtaq

et al. 2019

Int J Contemp Pediatr

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“…Iron, B12, and folate deficiencies are considered the major reason behind the deficiency anemias. Mukherjee et al reported the prevalence of iron deficiency in about 47% of his study subjects (4). The primary reason behind the coagulopathy is possibly endothelial dysfunction, platelet activation, and hemostatic abnormalities.…”

Section: Metabolic and Endocrinological Comorbiditiesmentioning

confidence: 90%

Extra-cardiac comorbidities or complications in adults with congenital heart disease: a nationwide inpatient experience in the United States

Singh¹,

Desai²,

Fong³

et al. 2018

Cardiovasc. Diagn. Ther

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With a great interest, we read the article by Neidenbach et al. on non-cardiac comorbidities in German adults with congenital heart disease (ACHD) (1). ACHD always bear an increased risk of developing concomitant noncardiac comorbidities and complications and impose a great healthcare burden (1). However, this study being a single-center analysis might lack generalization for any other larger population. Limited large-scale data from the United States (US) on this focus incited us to write this correspondence. Gilboa et al. estimated nearly 2.4 million people living with CHD (1.4 million adults, 1 million children) in the US in 2010 (2). To have a better nationwide prospect of the current scenario, we looked at the extracardiac comorbidities among ACHD patients hospitalized

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“…Both cyanotic and acyanotic congenital heart diseases have risks of iron reserves depletion in the body. The study by Mukherjee et al, (2018) showed 5 to 10 patients with cyanotic CHDs suffered from iron deficiency (Mukherjee et al, 2018). Meanwhile, Binh et al, (2018) reported 77.8% and 87.2% cyanotic and acyanotic CHD patients respectively suffered from the decrease in iron levels in the blood.…”

Section: Introductionmentioning

confidence: 98%

The Differences in Mentzer Index between Cyanotic and Acyanotic Congenital Heart Diseases

ulina¹,

Adriansyah²

2021

IJRP

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The prevalence of congenital heart diseases (CHDs) was estimated to be 8-12 per 1000 live births. Around 77.8% and 87.2% of cyanotic and asyanotic CHD cases experienced decrease in iron levels in the blood respectively. Anemia in children with CHDs, especially with cyanosis and high hematocrit levels due to chronic hypoxia, were often underdiagnosed. The Mentzer index as a diagnostic tool for anemia was used to diagnose iron deficiency in children with cyanotic and acyanotic CHDs. This research was a cross-sectional study done in Haji Adam Malik hospital by using data from medical records. Among 110 samples, TOF and VSD were diagnosed the most in cyanotic and acyanotic CHDs respectively in children aged 1 -5 years old. Hematological parameters such as hemoglobin, hematocrit and erythrocyte showed significant value (p<0.05) statistically. The difference of the Mentzer index with Mann-Whitney test showed significant difference (p<0.05) with median value of 12.0±3.9 and 17.2 ±4.2 in cyanotic and acyanotic CHD respectively.

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Iron deficiency anemia in children with cyanotic congenital heart disease and effect on cyanotic spells

Abstract: The prevalence of IDA in children with CCHD was found to be high. Iron-deficient group had an increased frequency of cyanotic spells as compared to the non-deficient group, which was statistically significant.

Cited by 17 publications

References 20 publications

Prevalence, profile of malnutrition and iron deficiency anemia in children with cyanotic congenital heart defects: a case control observational study in a tertiary care hospital in North India

Prevalence, profile of malnutrition and iron deficiency anemia in children with cyanotic congenital heart defects: a case control observational study in a tertiary care hospital in North India

Extra-cardiac comorbidities or complications in adults with congenital heart disease: a nationwide inpatient experience in the United States

The Differences in Mentzer Index between Cyanotic and Acyanotic Congenital Heart Diseases

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