Iron Deficiency Anemia-Induced Neutropenia in Adult Female

Abdelmahmuod, Elabbass; Yassin, Mohamed A; Ahmed, Mohanad

doi:10.7759/cureus.8899

Cited by 9 publications

(9 citation statements)

References 8 publications

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“…While iron overload and high heme levels are known to impair the function of mature neutrophils ( 50 , 51 ), how iron scarcity specifically affects neutrophils is not well understood ( 52 ). Cases of neutropenia associated with iron deficiency and reversed upon iron therapy have been reported ( 53 , 54 ). In addition, DFP, an iron chelator mainly used to treat iron overload in patients with thalassemia, has been shown to cause neutropenia via a yet unclear mechanism ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

Iron regulatory protein (IRP)–mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow

et al. 2022

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Iron is mostly devoted to the hemoglobinization of erythrocytes for oxygen transport. However, emerging evidence points to a broader role for the metal in hematopoiesis, including the formation of the immune system. Iron availability in mammalian cells is controlled by iron-regulatory protein 1 (IRP1) and IRP2. We report that global disruption of both IRP1 and IRP2 in adult mice impairs neutrophil development and differentiation in the bone marrow, yielding immature neutrophils with abnormally high glycolytic and autophagic activity, resulting in neutropenia. IRPs promote neutrophil differentiation in a cell intrinsic manner by securing cellular iron supply together with transcriptional control of neutropoiesis to facilitate differentiation to fully mature neutrophils. Unlike neutrophils, monocyte count was not affected by IRP and iron deficiency, suggesting a lineage-specific effect of iron on myeloid output. This study unveils the previously unrecognized importance of IRPs and iron metabolism in the formation of a major branch of the innate immune system.

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Section: Discussionmentioning

confidence: 99%

Iron regulatory protein (IRP)–mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow

et al. 2022

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“…While iron overload and high heme levels are known to impair the function of mature neutrophils (Martins et al, 2016, Renassia et al, 2020), how iron scarcity specifically affects neutrophils is not well understood (Abuga et al, 2020). Cases of neutropenia associated with iron deficiency and reversed upon iron therapy have been reported (Abuirmeileh et al, 2014, Abdelmahmuod et al, 2020). Also, DFP, an iron chelator mainly used to treat iron overload in Thalassemia patients, has been shown to cause neutropenia via a yet unclear mechanism (Kontoghiorghes et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Iron Regulatory Protein (Irp)-Mediated Iron Homeostasis Is Critical for Neutrophil Development and Differentiation in the Bone Marrow

Bonadonna

Altamura

Tybl

et al. 2022

Preprint

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Iron is mostly devoted to the hemoglobinization of erythrocytes for oxygen transport. Yet, emerging evidence points to a broader role for the metal in hematopoiesis, including the formation of the immune system. Iron availability in mammalian cells is controlled by iron-regulatory proteins (IRP)-1 and -2. We report that global disruption of both IRP1 and IRP2 in adult mice impairs neutrophil development and differentiation in the bone marrow, yielding immature neutrophils with abnormally high glycolytic and autophagic activity, resulting in neutropenia. IRPs promote neutrophil differentiation in a cell intrinsic manner by securing cellular iron supply together with transcriptional control of neutropoiesis to facilitate differentiation to fully mature neutrophils. Unlike neutrophils, monocyte count was not affected by IRP and iron deficiency, suggesting a lineage-specific effect of iron on myeloid output. This study unveils the previously unrecognized importance of IRPs and iron metabolism in the formation of a major branch of the innate immune system.

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“…Therefore, in this study, the possible hematomodulation of Scrophularia striata extract against AgNPs-induced hepatoxicity was investigated. The CBC test, which examines the morphological characteristics and number of different types of blood cells (Red blood cells, Leukocytes, and Platelets) per cubic millimeter of blood, is one of the most common tests and provides valuable infor-mation about different types of blood cell disorders, such as anemia (24).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Scrophularia striata Hydroalcoholic Extract's Hematomodulatory Effects: An Approach to Traditional Ethnomedicine

Shamohammadi

Pooyanmehr

Maleki

2022

J Clin Res Paramed Sci

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Background: Silver nanoparticles (AgNPs) have broad biomedical applications and may result in a high risk of human and environmental toxicity. Scrophularia striata possesses a strong antioxidant capacity. Objectives: This study seeks to examine the modulatory influence of S. striata hydroalcoholic extract on the toxicity of silver nanoparticles on blood granulocytes, agranulocytes, and general parameters in male Wistar rats. Methods: Thirty male rats weighing an average of 200 ± 20 were divided into five experimental groups of six. In 30 days, rats were given 2 mL of distilled water in group 1 (negative control), 200 ppm AgNPs (hepatotoxicity dosage) in group 2, as well as 20, 60, and 180 mg/kg S. striata extract and 200 ppm AgNPs in groups 3, 4, and 5. Rats’ blood samples were taken 24 hours following their last partial anesthesia treatment. One-way ANOVA was used to evaluate the data, followed by Tukey's post hoc test. Results: When compared to the control groups, oral treatment of AgNPs resulted in substantial changes in WBC, NE, LY, MO, EO, BA, RBC, Hb, HCT, MCV, MCH, MCHC, PLT, and MPV levels. In comparison to the positive and negative groups, the extract's modulatory effects on hematological parameters demonstrated substantial variations, especially in groups 4 and 5 (60 and 180 mg/kg). Conclusions: Due to the presence of some unique components, such as flavonoids, the extract of the S. striata plant was discovered to be an efficient hematomodulatory, compensating to some extent for the cytotoxic side effects of AgNPs within the body.

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Iron Deficiency Anemia-Induced Neutropenia in Adult Female

Cited by 9 publications

References 8 publications

Iron regulatory protein (IRP)–mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow

Iron regulatory protein (IRP)–mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow

Iron Regulatory Protein (Irp)-Mediated Iron Homeostasis Is Critical for Neutrophil Development and Differentiation in the Bone Marrow

Evaluation of Scrophularia striata Hydroalcoholic Extract's Hematomodulatory Effects: An Approach to Traditional Ethnomedicine

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