Iron deficiency in Greece

Kattamis, C; Metaxotou-Mavromnati, A.; Konidaris, C.; Touliatos, N.; Constantsas, N.S.; Matsaniotis, N

doi:10.1016/s0022-3476(74)80007-7

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…Considering the high incidence of all types of the thalassaemia trait in Greece, which is about 8% in the general population (Malamos et a!, 1962;Kattamis, 1971) and as high as 18-20% incertain areas (Kattamis et ul,197z), it is not surprising that nearly all double heterozygotes for pand 6p-thalassaemia have been described among Greeks.…”

Section: 08f061mentioning

confidence: 99%

The Clinical and Haematological Findings in Children Inheriting Two Types of Thalassaemia: High‐A₂ Type β‐Thalassaemia, and High‐F Type or δβ‐Thalassaemia

et al. 1973

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Summary. Eleven children who are double heterozygotes for β‐ and δβ‐thalassaemia are described. Of their parents one was always heterozygous for β‐(A2) thalassaemia (increased Hb A2), and the other for the high F variant or δβ‐thalassaemia (increased Hb F). The clinical syndrome resulting from the combination of β‐ and δβ‐thalassaemia shows some heterogeneity, but in general is of intermediate severity. Red cell abnormalities were considerable, Hb F was very high (mean 70.3 ± 12.6%), Hb A2 was low or normal (mean 2.36 ± 1.52%), and Hb A was absent in five patients. Hb F was nearly homogeneously distributed in the red cells of most patients. These findings are explained as the outcome of a mutation which suppresses δ‐ and β ‐chain synthesis which is associated with a genetically determined increased production of γ‐ chains.

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Section: 08f061mentioning

confidence: 99%

The Clinical and Haematological Findings in Children Inheriting Two Types of Thalassaemia: High‐A₂ Type β‐Thalassaemia, and High‐F Type or δβ‐Thalassaemia

et al. 1973

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“…In addition, there are some rare variants which can be detected only by chain synthesis. [3][4][5] Complete haematological examination to establish the diagnosis of a heterozygote for ,-thalassaemia is laborious and time consuming. For this reason a number of tests have been proposed for screening of heterozygotes with 3-thalassaemia.…”

mentioning

confidence: 99%

Effectiveness of one tube osmotic fragility screening in detecting beta-thalassaemia trait.

Kattamis¹,

Ефремов²,

Pootrakul³

1981

Journal of Medical Genetics

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SUMMARY The effectiveness of the one tube method of osmotic fragility with three buffered solutions (0-32 %°saline, 0 36 % saline, and tyrode) as a screening test for f-thalassaemia trait was evaluated in several groups of subjects from Greece, Yugoslavia, and Thailand. The results clearly demonstrated that 0 36 % saline is the most sensitive and effective solution since it could detect 96 to 100% of heterozygotes with r-thalassaemia, compared to about 80%. with both 0-32% saline and tyrode.However, 0 36 % saline gave false positive results in normal subjects and was also positive in haematological disorders which influence osmotic fragility. The screening test with 0-36% saline was applied more precisely in 1371 subjects. The test was false positive in 41 (9-1 %) of 455 normal subjects while of 438 confirmed heterozygotes with 3-thalassaemia it was positive in 431 (98 %) and negative in only seven (2 %). The test was also found to be positive in 80 % of patients with iron deficiency anaemia and ao-thalassaemia trait, in 68 % of patients with Hb E trait, in 40 % of patients with Hb S trait, and in 78 % of heterozygotes with rare haemoglobin variants.The increased sensitivity and effectiveness of 0.36% saline in detecting p-thalassaemia trait and other disorders influencing osmotic fragility as compared to 0-32 % saline and tyrode solutions was also confirmed in a study of 384 unselected schoolchildren.The ,-thalassaemias have been described all over the world,1 2 but in certain countries the high prevalence of the abnormal gene causes serious problems in public health. In general, heterozygotes for the r-thalassaemias are characterised by hypochromic microcytic anaemia, decreased red cell osmotic fragility, and raised Hb A2 or Hb F or both. In addition, there are some rare variants which can be detected only by chain synthesis.3-5

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“…Aneminin yaş gruplarına göre dağılımı; 1-3 yaşta 205 (%8,1) kişi, 4-6 yaşta 97 (%3,4) kişi, 7-9 yaşta 98 (%3,6) kişi, 10-12 yaşta 128 (%4,9) kişi, 13-15 yaşta 325 (%8,9) kişi şeklindeydi. Ortalama Hb değeri 1-3 yaş grubunda 12,32±1,15 gr/ dl (6,9-16), 4-6 yaş grubunda 12,5±1,05 (7,9-17), 7-9 yaş grubunda 13,1±1,03 (6-17), 10-12 yaş grubunda 13,6±1,02 (6,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) Tüm dünyada olduğu gibi ülkemizde yapılan çok sayıda çalışmada aneminin en sık nedeni demir eksikliğidir. Demir eksikliği anemisi (DEA) süt çocukluğu döneminde Arjantin'de %46,7, Kosta Rika'da %25, Kanada'da yaşayan Çinli'lerde %12,1, Yunanistan'da 6 ay 5 yaş arası çocuklarda %33,6, ABD'de çocuk ve ergenlerde %2-5 oranında bulunmuştur (7)(8)(9)(10)(11)(12).…”

Section: Gereç Ve Yöntemunclassified

“…Ortalama Hb değeri 1-3 yaş grubunda 12,32±1,15 gr/ dl (6,9-16), 4-6 yaş grubunda 12,5±1,05 (7,9-17), 7-9 yaş grubunda 13,1±1,03 (6-17), 10-12 yaş grubunda 13,6±1,02 (6,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) Tüm dünyada olduğu gibi ülkemizde yapılan çok sayıda çalışmada aneminin en sık nedeni demir eksikliğidir. Demir eksikliği anemisi (DEA) süt çocukluğu döneminde Arjantin'de %46,7, Kosta Rika'da %25, Kanada'da yaşayan Çinli'lerde %12,1, Yunanistan'da 6 ay 5 yaş arası çocuklarda %33,6, ABD'de çocuk ve ergenlerde %2-5 oranında bulunmuştur (7)(8)(9)(10)(11)(12). DEA sıklığı Türkiye'de 1974'te 0-5 yaş arası çocuklarda yapılan bir çalışmada %73, Marmara bölgesinde 1975'te 0-12 yaş arası çocuklarda yapılan bir çalışmada %79 ve İstanbul'da 1997'de 6 ay-19 yaş arası çocuklarda ve ergenlerde yapılan bir çalışmada %44,3 bulunmuştur (14)(15)(16)(17)(18)(19).…”

Section: Gereç Ve Yöntemunclassified

The Prevalence of Anemia Among Children Aged 1-15 Admitted to Hospital in Sivas

Karagün¹,

Korkmaz²,

Gürsu³

et al. 2014

jcp

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Özet Giriş: Bu çalışmada Sivas ilinde hastaneye başvuran 1-15 yaş grubu çocuklardaki anemi sıklığının değerlendirilmesini amaçladık. Gereç ve Yöntem: Çocuk polikliniğine 01.01.2012-31.12.2012 tarihleri arasında başvuran kronik hastalığı olmayan 1-15 yaş arası 14449 olgu hastane kayıtlarından retrospektif olarak anemi prevelansının değerlendirilebilmesi amacıyla çalışmaya alındı. Bulgular: Hastaneye başvuran olguların 8742'si (%60,5) erkek, 5707'si (%39,5) kız idi. Tüm olgular 1-3 yaş 2531 (%17,5), 4-6 yaş 2872 (%19,9), 7-9 yaş 2735(%18,9), 10-12 yaş 2637 (%18,3), 13-15 yaş 3674 (%25,4) olmak üzere beş gruptan oluşmaktaydı. Anemi saptanan 853 (%5,9) hastanın 465'i (%54,5) erkek, 388'i (%45,5) kız idi. Aneminin yaş gruplarına göre dağılımı: 1-3 yaşta 205 (%8,1) kişi, 4-6 yaşta 97 (%3,4) kişi, 7-9 yaşta 98 (%3,6) kişi, 10-12 yaşta 128 (%4,9) kişi, 13-15 yaşta 325 (%8,9) kişi idi. Düşük MCV (ortalama; 82,2±5,34 (47,4-110,8)) değerine sahip olgular tüm çalışma grubunun %6,3 (905) içermekteydi. Düşük MCV değeri yaş gruplarına göre: 1-3 yaş; %9,4 (237), 4-6 yaş; %5,3 (151), 7-9 yaş; %3,8 (104), 10-12 yaş; %4,5 (119), 13-15 yaş; %8 (294) şeklinde bir dağılım göstermekteydi. Sonuç: Anemi tüm çocukluk yaş grubunun en sık görülen hastalıklarından birisidir. Ülkemizde uygulanan sağlık politikalarına rağmen çocukluk yaş grubunda önemli bir sağlık sorunu olmaya devam etmektedir. Hekimler çocukluk yaş grubunda anemi konusunda uyanık olmalı, aileleri bu konuda bilinçlendirmelidir. Ayrıca çocuk sağlığını ve zeka gelişimini olumsuz etkileyen bu durumun giderilmesi için çalışılmalıdır. (Gün cel Pe di at ri 2014;2:67-72) Introduction: In this study, we aimed to determine the incidence of anemia in children between the ages of 1-15.

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Iron deficiency in Greece

Cited by 5 publications

References 11 publications

The Clinical and Haematological Findings in Children Inheriting Two Types of Thalassaemia: High‐A₂ Type β‐Thalassaemia, and High‐F Type or δβ‐Thalassaemia

The Clinical and Haematological Findings in Children Inheriting Two Types of Thalassaemia: High‐A₂ Type β‐Thalassaemia, and High‐F Type or δβ‐Thalassaemia

Effectiveness of one tube osmotic fragility screening in detecting beta-thalassaemia trait.

The Prevalence of Anemia Among Children Aged 1-15 Admitted to Hospital in Sivas

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Iron deficiency in Greece

Cited by 5 publications

References 11 publications

The Clinical and Haematological Findings in Children Inheriting Two Types of Thalassaemia: High‐A2 Type β‐Thalassaemia, and High‐F Type or δβ‐Thalassaemia

The Clinical and Haematological Findings in Children Inheriting Two Types of Thalassaemia: High‐A2 Type β‐Thalassaemia, and High‐F Type or δβ‐Thalassaemia

Effectiveness of one tube osmotic fragility screening in detecting beta-thalassaemia trait.

The Prevalence of Anemia Among Children Aged 1-15 Admitted to Hospital in Sivas

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Resources

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The Clinical and Haematological Findings in Children Inheriting Two Types of Thalassaemia: High‐A₂ Type β‐Thalassaemia, and High‐F Type or δβ‐Thalassaemia

The Clinical and Haematological Findings in Children Inheriting Two Types of Thalassaemia: High‐A₂ Type β‐Thalassaemia, and High‐F Type or δβ‐Thalassaemia