Iron Deficiency in Monkeys Fed Diets Containing Soybean Protein.

Fitch, Coy D.; Harville, W. E.; Dinning, James S.; Porter, F. Stanley

doi:10.3181/00379727-116-29180

Cited by 25 publications

(3 citation statements)

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“…Species differences also complicate results. Davis et al (1962) found good utilization of iron from soybean isolates by the chick, while Fitch et al (1964) observed poor utilization by the monkey. Man has been reported to utilize iron from soybean well (Layrisse et al, 1969).…”

Section: Iron Bioavailability From Soybean Isolatementioning

confidence: 99%

Influence of Fish on the Bioavailability of Plant Iron in the Anemic Rat

Chao

Gordon

1983

The Journal of Nutrition

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The effect of fish protein and fish oil on the utilization of endogenous iron in wheat bran, spinach and soy protein isolate was investigated by using the anemic rat as an animal model. Marine products were substituted for casein and corn oil in the diets of these animals. Hemoglobin regeneration was one criteria used to measure iron uptake. Relative biological values (RBV) were computed from a regression equation obtained from control animals receiving graded levels of FeSO4 X 7H2O. The RBV of iron from plant sources provided in diets containing casein-corn oil versus fish-fish oil were: wheat bran, 123 vs. 111%; spinach, 53 vs. 49%; and soybean isolate, 84 vs. 67%; RBV FeSO4 = 100%. These changes were not significant. The decreases in iron absorption from diets containing marine products was attributed to the fish oil. Absorption of exogenous iron (59Fe) was measured in the same animals after the 14-day repletion period. Assimilation of the 59Fe was highly correlated (r2 = 0.958) with hemoglobin level at time of dosing. Diet composition did not appear to have the same effect on the percentage of 59Fe retained after 110 hours by the rat as compared to levels of hemoglobin regeneration (i.e., RBV). A "meat factor" effect was not shown by substituting fish for casein the diets containing plant iron sources fed anemic rats.

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Section: Iron Bioavailability From Soybean Isolatementioning

confidence: 99%

Influence of Fish on the Bioavailability of Plant Iron in the Anemic Rat

Chao

Gordon

1983

The Journal of Nutrition

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“…Their diets and general handling have been described previously (Dinning et a/. 1957, Fitch et a/. 1964.…”

Section: E T H O D Smentioning

confidence: 99%

Vitamin E Deficiency in The Monkey X. Protoporphyrin and Haeme Synthesis by Peripheral Blood and Bone Marrow

Porter¹,

Fitch²

1966

Scandinavian Journal of Haematology

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In vitro studies of porphyrin and haeme synthesis by bone marrow cells from vitamin E‐deficient monkeys indicate that vitamin E is required for the normal synthesis of these compounds. The defect in porphyrin synthesis apparently results from abnormal delta‐aminolaevulinic acid synthesis. This defect was not found in the reticulocytes of peripheral blood. The administration of vitamin E corrected the abnormality in porphyrin synthesis, but the addition of vitamin E in vitro did not. Coenzyme Q10 administration also resulted in increased porphyrin synthesis by the bone marrow cells of vitamin E‐deficient monkeys.

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“…Young rhesus monkeys (Macaca multatta) were fed a soybean protein-based, vitamin E-deficient diet lsee Table I of Ref. This extra supplement of iron is more than enough to prevent the occurence of iron-decciency anemia, which otherwise may occur in monkeys fed this diet ( 7 ) . This extra supplement of iron is more than enough to prevent the occurence of iron-decciency anemia, which otherwise may occur in monkeys fed this diet ( 7 ) .…”

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confidence: 99%