Iron deficiency in non-anemic chronic obstructive pulmonary disease in a predominantly male population: an ignored entity

Rathi, Vidushi; Ish, Pranav; Singh, GK; Tiwari, Mahavir Prasad; Goel, Nitin; Gaur, Shailendra Nath

doi:10.4081/monaldi.2020.1126

Cited by 7 publications

(8 citation statements)

References 19 publications

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“…Iron deficiency in COPD patients was associated with reduced exercise tolerance and increased exacerbation frequency, though it is unclear whether the effects were associated with dietary intake or microbiome composition 233 . Finally, remodelling of the airway epithelium in COPD patients contributes to the dysregulation of PUFA metabolism in the lung 234 .…”

Section: Dysbiosis Of Gut Microbiome In Diet‐related Immune Disordersmentioning

confidence: 99%

Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders

Alemao

Budden

Gomez

et al. 2020

Allergy

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The prevalence of chronic immune and metabolic disorders is increasing rapidly. In particular, inflammatory bowel diseases, obesity, diabetes, asthma and chronic obstructive pulmonary disease have become major healthcare and economic burdens worldwide. Recent advances in microbiome research have led to significant discoveries of associative links between alterations in the microbiome and health, as well as these chronic supposedly noncommunicable, immune/metabolic disorders. Importantly, the interplay between diet, microbiome and the mucous barrier in these diseases has gained significant attention. Diet modulates the mucous barrier via alterations in gut microbiota, resulting in either disease onset/exacerbation due to a “poor” diet or protection against disease with a “healthy” diet. In addition, many mucosa‐associated disorders possess a specific gut microbiome fingerprint associated with the composition of the mucous barrier, which is further influenced by host‐microbiome and inter‐microbial interactions, dietary choices, microbe immigration and antimicrobials. Our review focuses on the interactions of diet (macronutrients and micronutrients), gut microbiota and mucous barriers (gastrointestinal and respiratory tract) and their importance in the onset and/or progression of major immune/metabolic disorders. We also highlight the key mechanisms that could be targeted therapeutically to prevent and/or treat these disorders.

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Section: Dysbiosis Of Gut Microbiome In Diet‐related Immune Disordersmentioning

confidence: 99%

Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders

Alemao

Budden

Gomez

et al. 2020

Allergy

View full text Add to dashboard Cite

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“…It has been estimated that iron deficiency may take place in approximately 40–50% of the COPD patients [ 3 , 4 , 5 ]. Alterations in iron homeostasis may negatively impact disease progression and functional status in COPD [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Iron Depletion in Systemic and Muscle Compartments Defines a Specific Phenotype of Severe COPD in Female and Male Patients: Implications in Exercise Tolerance

et al. 2022

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We hypothesized that iron content and regulatory factors, which may be involved in exercise tolerance, are differentially expressed in systemic and muscle compartments in iron deficient severe chronic obstructive pulmonary disease (COPD) patients. In the vastus lateralis and blood of severe COPD patients with/without iron depletion, iron content and regulators, exercise capacity, and muscle function were evaluated in 40 severe COPD patients: non-iron deficiency (NID) and iron deficiency (ID) (20 patients/group). In ID compared to NID patients, exercise capacity, muscle iron and ferritin content, serum transferrin saturation, hepcidin-25, and hemojuvelin decreased, while serum transferrin and soluble transferrin receptor and muscle IRP-1 and IRP-2 increased. Among all COPD, a significant positive correlation was detected between FEV1 and serum transferrin saturation. In ID patients, significant positive correlations were detected between serum ferritin, hepcidin, and muscle iron content and exercise tolerance and between muscle IRP-2 and serum ferritin and hepcidin levels. In ID severe COPD patients, iron content and its regulators are differentially expressed. A potential crosstalk between systemic and muscle compartments was observed in the ID patients. Lung function and exercise capacity were associated with several markers of iron metabolism regulation. Iron status should be included in the overall assessment of COPD patients given its implications in their exercise performance.

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“…However, it has been reported that patients with COPD have lower dietary intake of calcium, phosphorus, and iron compared with that of healthy control subjects, 124 and patients with COPD with iron deficiency have less exercise capacity, more frequent exacerbations, and increased COPD severity than do patients with COPD who do not have iron deficiency. 125 , 126 Whether low mineral status also affects lung function and COPD risk remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Nutrition as a modifiable factor in the onset and progression of pulmonary function impairment in COPD: a systematic review

et al. 2022

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Context Chronic obstructive lung disease (COPD) is a progressive lung disease characterized by persistent airflow limitation. An increasing amount of evidence suggests an effect of dietary quality on the risk of COPD in the general population and pulmonary function decline in patients with COPD. Objective The association of dietary intake and nutrient status with COPD risk and onset, as well as pulmonary function decline (change in forced expiratory volume in 1 second, forced vital capacity, or the ratio of the former to the latter) in patients with COPD was investigated in this systematic review. Data Sources The PubMed database was searched by combining terms of pulmonary function or COPD with diet, nutrient status, or nutritional supplementation. Data Extraction Original studies and systematic reviews and meta-analyses were included. Articles obtained were independently screened for relevance on the bases of title and abstract by 2 researchers. Eventually, 89 articles were included in the analysis. Results The unhealthy Western-style diet is associated with an increased risk of COPD and an accelerated decline of pulmonary function. Intake of fruit, vegetables, dietary fibers, vitamins C and E, polyphenols, and β-carotene were individually associated with lower COPD risk, whereas consumption of processed meat was associated with higher COPD risk. Data on the effect of dietary quality on pulmonary function decline in patients with COPD are limited and inconsistent. Strong evidence for beneficial effects on pulmonary function decline was found only for vitamin D supplementation. Conclusion Considering the increasing burden of COPD, more attention should be given to dietary quality as a modifiable factor in disease development and progression in patients with COPD. Systematic Review Registration PROSPERO registration no. CRD42021240183.

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Iron deficiency in non-anemic chronic obstructive pulmonary disease in a predominantly male population: an ignored entity

Cited by 7 publications

References 19 publications

Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders

Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders

Iron Depletion in Systemic and Muscle Compartments Defines a Specific Phenotype of Severe COPD in Female and Male Patients: Implications in Exercise Tolerance

Nutrition as a modifiable factor in the onset and progression of pulmonary function impairment in COPD: a systematic review

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