Iron Deficiency in the Rat: Effects of Oxidative Metabolism in Distinct Types of Skeletal Muscle

Mackler, Bruce; Grace, Richard; Finch, C. A.

doi:10.1203/00006450-198406000-00001

Cited by 33 publications

(16 citation statements)

References 8 publications

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“…Multifaceted detrimental effects of ID for the organism in the context of skeletal muscles involve decreased productivity and exercise capacity, and several alterations within the muscle tissue ( Figure ). Experimental data from in vitro and animal studies reveal that skeletal muscle energetics suffer from iron depletion at different levels, from shifts in energy substrate preferences to subcellular and molecular derangements, which result mostly in a decrement of oxidative capacity ( Figure ) …”

Section: Molecular Effects Of Depleted Iron On Skeletal Muscle Energementioning

confidence: 99%

The influence of iron deficiency on the functioning of skeletal muscles: experimental evidence and clinical implications

Stugiewicz

Tkaczyszyn

Kasztura

et al. 2016

European J of Heart Fail

123

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Skeletal and respiratory myopathy not only constitutes an important pathophysiological feature of heart failure and chronic obstructive pulmonary disease, but also contributes to debilitating symptomatology and predicts worse outcomes in these patients. Accumulated evidence from laboratory experiments, animal models, and interventional studies in sports medicine suggests that undisturbed systemic iron homeostasis significantly contributes to the effective functioning of skeletal muscles. In this review, we discuss the role of iron status for the functioning of skeletal muscle tissue, and highlight iron deficiency as an emerging therapeutic target in chronic diseases accompanied by a marked muscle dysfunction.

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Section: Molecular Effects Of Depleted Iron On Skeletal Muscle Energementioning

confidence: 99%

The influence of iron deficiency on the functioning of skeletal muscles: experimental evidence and clinical implications

Stugiewicz

Tkaczyszyn

Kasztura

et al. 2016

European J of Heart Fail

123

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“…Poor physical growth, gastrointestinal disturbances, thyroid dysfunction, altered immunity and temperature instability have been attributed to iron de ciency in very low birthweight infants (20). Skeletal muscle dysfunction and altered cardiac contractility may result from tissue iron de ciency (38,39). A major concern of early iron de ciency is its effect on the developing brain (1,2).…”

Section: Potential Implications Of Early Iron De Ciency On Neurodevelmentioning

confidence: 99%

Perinatal aspects of iron metabolism

Georgieff

2002

Acta Paediatrica

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“…Being the crucial micronutrient for several intracellular processes responsible for energy generation, iron plays the important role for the effective functioning of skeletal muscle tissue . In experimental studies (including animal models), ID is associated with complex alterations within skeletal muscle tissue and decreased work capacity, and there are some indirect data from sports medicine suggesting the relationship between ID and skeletal muscle dysfunction in humans …”

Section: Introductionmentioning

confidence: 99%

“…10 Being the crucial micronutrient for several intracellular processes responsible for energy generation, iron plays the important role for the effective functioning of skeletal muscle tissue. 11 In experimental studies (including animal models), ID is associated with complex alterations within skeletal muscle tissue and decreased work capacity, [12][13][14][15] and there are some indirect data from sports medicine suggesting the relationship between ID and skeletal muscle dysfunction in humans. [16][17][18][19] In the current study, we aimed to (i) assess the relationships between respiratory muscle function, skeletal muscle mass, and physical fitness in men with HF with reduced left ventricular ejection fraction (HFrEF) and (ii) to investigate our recent hypothesis 11 of whether ID contributes to respiratory muscle dysfunction in these patients independently of disease severity and indices of skeletal muscle mass.…”

Section: Introductionmentioning

confidence: 99%

Depleted iron stores are associated with inspiratory muscle weakness independently of skeletal muscle mass in men with systolic chronic heart failure

Tkaczyszyn

Drozd

Węgrzynowska‐Teodorczyk

et al. 2018

J cachexia sarcopenia muscle

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BackgroundSkeletal and respiratory muscle dysfunction constitutes an important pathophysiological feature of heart failure (HF). We assessed the relationships between respiratory muscle function, skeletal muscle mass, and physical fitness in men with HF with reduced left ventricular ejection fraction (HFrEF), and investigated the hypothesis of whether iron deficiency (ID) contributes to respiratory muscle dysfunction in these patients.MethodsWe examined 53 male outpatients with stable HFrEF without asthma or chronic obstructive pulmonary disease (age: 64 ± 10 years; New York Heart Association [NYHA] class I/II/III: 36/51/13%; ischaemic aetiology: 83%; all with left ventricular ejection fraction ≤40%) and 10 middle‐aged healthy men (control group). We analysed respiratory muscle function (maximal inspiratory and expiratory pressure at the mouth [MIP and MEP, respectively]), appendicular lean mass/body mass index (ALM/BMI; ALM was measured using dual‐energy X‐ray absorptiometry), physical fitness (components of Functional Fitness Test for Older Adults), and iron status.ResultsMIP, MEP, and ALM/BMI (but not MIP adjusted for ALM/BMI) were lower in men with HFrEF vs. healthy men. MIP, MEP, and MIP adjusted for ALM/BMI (but not ALM/BMI) were lower in men with HFrEF with vs. without ID. In a multivariable linear regression model lower serum ferritin (but not transferrin saturation) was associated with lower MIP independently of ALM/BMI, left ventricular ejection fraction, N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), and haemoglobin concentration. In multivariable linear regression models, lower MIP was associated with worse results in Functional Fitness Test when adjusted for ALM/BMI or relevant clinical variables (NYHA class, estimated glomerular filtration rate, NT‐proBNP, and haemoglobin concentration).ConclusionsIn men with HFrEF, low ferritin reflecting depleted iron stores is associated with inspiratory muscle weakness independently of skeletal muscle mass. Inspiratory muscle dysfunction correlates with worse physical fitness independently of either skeletal muscle mass or disease severity.

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Iron Deficiency in the Rat: Effects of Oxidative Metabolism in Distinct Types of Skeletal Muscle

Cited by 33 publications

References 8 publications

The influence of iron deficiency on the functioning of skeletal muscles: experimental evidence and clinical implications

The influence of iron deficiency on the functioning of skeletal muscles: experimental evidence and clinical implications

Perinatal aspects of iron metabolism

Depleted iron stores are associated with inspiratory muscle weakness independently of skeletal muscle mass in men with systolic chronic heart failure

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