Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells

Abstract

When iron deficient, the expression of IGTB and Cdc42 in vascular smooth muscle cells (VSMCs) is reduced, while the expression of Rac-1 is increased. In

A Novel Serum Biomarker Model to Discriminate Aortic Dissection from Coronary Artery Disease

“…Optimal threshold value was obtained from the data, which was the threshold leading to the maximum summation of sensitivity and specificity (i.e., the Youden index). 9 Disease Markers degeneration of the aorta in hypertensive patients [21]. In contrast, Edvinsson et al revealed that compared with normal controls, Cu 2+ and Zn 2+ decreased and Fe 2+ tended to increase in aortic tissue [17].…”

“…Iron, as one of the essential trace elements for the human body, has received extensive attention for a long time [ 20 ]. Recently, Li et al demonstrated that iron deficiency contributes to the development of medial degeneration of the aorta in hypertensive patients [ 21 ]. In contrast, Edvinsson et al revealed that compared with normal controls, Cu 2+ and Zn 2+ decreased and Fe 2+ tended to increase in aortic tissue [ 17 ].…”

Iron deficiency exacerbates aortic medial degeneration by inducing excessive mitochondrial fission

“…37,38 Our previous study demonstrated that ID exacerbated aortic expansion by destroying the cytoskeleton. 8 It is known that the phenotypic switch of VSMCs from stable contractile cells to secretory and proliferative cells is the main underlying mechanism of AMD. 39 In our study, the overexpression of factors related to mitochondrial fission induced phenotypic transformation.…”

“…6,7 Our previous study showed that an iron-deficient diet (IDD) degraded the cytoskeleton of the aortic media in mice, which played an important role in the development of AMD. 8…”

“…6,7 Our previous study showed that an iron-deficient diet (IDD) degraded the cytoskeleton of the aortic media in mice, which played an important role in the development of AMD. 8 As a dynamic organelle, mitochondria are constantly undergoing fusion and fission, which is referred to as mitochondrial dynamics. 9 Mitochondrial fusion and division are in a state of dynamic equilibrium under normal conditions.…”