Iron-doped brushite bone cement scaffold with enhanced osteoconductivity and antimicrobial properties for jaw regeneration

Pan, Xun; Huang, Jie; Zhang, Kaili; Pei, Zhengjun; Ding, Zhangfan; Liang, Yaxian; Gu, Zhipeng; Li, Guangda; Xie, Huixu

doi:10.1016/j.ceramint.2021.05.309

Cited by 15 publications

(7 citation statements)

References 34 publications

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“…BCS and S-BCS displayed similar spectra. Bands at 564 and 602 cm –1 were attributed to the PO 4 . − Bands at 3441 and 1035 cm –1 represented the crystal HA . Simultaneously, F-BCS and FS-BCS displayed similar FTIR spectra.…”

Section: Resultsmentioning

confidence: 86%

“…Fe also plays an essential role in enhancing bone metabolism . Although many studies have focused on the effect of iron loading on the osteogenic properties of bone grafting biomaterials, , few studies have focused on the impact of iron loading on the antibacterial properties of these materials. Recently, the development of iron-loaded antibacterial bone grafting materials has begun to receive attention.…”

Section: Introductionmentioning

confidence: 99%

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Injectable Self-Harden Antibiofilm Bioceramic Cement for Minimally Invasive Surgery

Li,

Ma,

et al. 2023

ACS Biomater. Sci. Eng.

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There is an urgent demand for antibacterial bone grafts in clinics. Worryingly, the misuse and overuse of antibiotics accelerate the emergence of drug-resistant bacteria. Therefore, this study prepared a novel injectable bioceramic cement without antibiotics (FS-BCS), which showed good antibacterial properties by loading iron and strontium onto a matrix composed of brushite and calcium sulfate. The setting time, injectability, microstructure, antibacterial properties, anti-biofilm properties, and cytocompatibility of the novel bioceramic cement were evaluated thoroughly. The results showed that the material was highly injectable and antiwashout. The antibacterial tests revealed that FS-BCS inhibited the growth of 99.9% E. coli and S. aureus separately in the broth due to the synergistic effect of strontium and iron. Simultaneously, crystal violet and fluorescent staining tests revealed that the material could significantly inhibit the formation of E. coli and S. aureus biofilms. In addition, the co-incorporation of iron and strontium promoted the proliferation and migration of osteoblasts. Therefore, FS-BCS has good application potential in antibiotic-free anti-infection bone grafting using minimally invasive surgery.

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Section: Resultsmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Injectable Self-Harden Antibiofilm Bioceramic Cement for Minimally Invasive Surgery

Li,

Ma,

et al. 2023

ACS Biomater. Sci. Eng.

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“…[214] CaP powders doped with magnetic ions are other alternatives to MNP also reported in literature and have shown promising results in bone regeneration. [50][51][52]207,[215][216][217][218][219] Magnetic apatite can be a bioactive, bioresorbable, nontoxic, and magnetoresponsive material. [51] To attain these magnetic-doped CaP particles, iron has been the prime ion selected, individually or combined with other ones, as, for example zinc, manganese, and/or cobalt.…”

Section: Calcium Phosphate-based Particles With Intrinsic Magnetic Pr...mentioning

confidence: 99%

Bioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP‐Based Particles and 3D‐Printed Scaffolds

Carvalho

Torres

Belo

et al. 2023

Advanced NanoBiomed Research

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Diverse applications of nanoparticles (NP) have been revolutionary for various industrial sectors worldwide. In particular, magnetic nanoparticles (MNP) have gained great interest because of their applications in specialized medical areas. This review starts with a brief overview of the magnetic behavior of MNP and a short description of their most used synthesis methods. The second part is dedicated to the MNP applications in tissue engineering, emphasizing the calcium phosphate‐based NP with intrinsic magnetic properties, recently highlighted in the literature as alternative and viable solutions for bone regeneration. The challenges associated with the controversial long‐term toxicity effects of MNP can be overcome using this new generation of multifunctional bone‐like magnetic materials. Furthermore, the influence of magnetic field parameters, such as modality of application, intensity, and spatial distribution, on the biological behavior of magnetic materials, especially for bone repair, is shown. The last part of the review presents the current state of the art regarding the development of magnetic biomaterials for additive manufacturing (AM), aiming to fabricate scaffolds by AM technologies, focusing on bone tissue engineering applications.

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“…The insufficient osteoconductivity of DCDP may be improved via elemental iron doping (Pan et al, 2021).…”

Section: Bone Regeneration From a Crystallographic Perspectivementioning

confidence: 99%

“…However, this issue was recently addressed by mixing DCPD with calcium sulfate dihydrate (Moussa et al, 2021). The insufficient osteoconductivity of DCDP may be improved via elemental iron doping (Pan et al, 2021).…”

Section: Microstructure and Mechanism Of Formation Of Enamel And Bonementioning

confidence: 99%

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

Saito

Onuma

Yamakoshi

2023

Genesis

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Summary The cementum is the outermost layer of hard tissue covering the dentin within the root portion of the teeth. It is the only hard tissue with a specialized structure and function that forms a part of both the teeth and periodontal tissue. As such, cementum is believed to be critical for periodontal tissue regeneration. In this review, we discuss the function and histological structure of the cementum to promote crystal engineering with a biochemical approach in cementum regenerative medicine. We review the microstructure of enamel and bone while discussing the mechanism underlying apatite crystal formation to infer the morphology of cementum apatite crystals and their complex structure with collagen fibers. Finally, the limitations of the current dental implant treatments in clinical practice are explored from the perspective of periodontal tissue regeneration. We anticipate the possibility of advancing periodontal tissue regenerative medicine via cementum regeneration using a combination of material science and biochemical methods.

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Iron-doped brushite bone cement scaffold with enhanced osteoconductivity and antimicrobial properties for jaw regeneration

Cited by 15 publications

References 34 publications

Injectable Self-Harden Antibiofilm Bioceramic Cement for Minimally Invasive Surgery

Injectable Self-Harden Antibiofilm Bioceramic Cement for Minimally Invasive Surgery

Bioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP‐Based Particles and 3D‐Printed Scaffolds

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

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