Iron exposure modifies acetylcholinesterase activity in zebrafish (Danio rerio) tissues: distinct susceptibility of tissues to iron overload

Sant'Anna, Maria Cristina Berta; Soares, Vanessa de Matas; Seibt, Kelly Juliana; Ghisleni, Gabriele; Rico, Eduardo Pacheco; Oliveira, Jarbas Rodrigues de; Schröder, Nadja; Bonan, Carla Denise; Bogo, Maurı́cio Reis

doi:10.1007/s10695-010-9459-7

Cited by 22 publications

(6 citation statements)

References 45 publications

(50 reference statements)

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“…The inhibition under the effect of Pb could be caused by binding the metal to the functional groups of proteins like imidazole, sulfhydryl, and carboxyl (23). There was emergence of catalytic activity loss in functional groups (24). It showed a significant inhibition of AChE in the brain and muscle tissues following sublethal administration of cadmium (Cd) to zebrafish (25).…”

Section: Discussionmentioning

confidence: 99%

Activity of acetylcholinesterase (AChE) in male albino rats exposed to metal welding fumes in an experimental setting

Adamu

Abdullahi

Ibrahim

2021

Environ Health Eng Manag

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Background: There are millions of workers in the world, who engage in activities associated with welding operations but are not classified as full-time metal workers. The present study aimed to determine the activity of acetylcholinesterase (AChE) in blood of laboratory animals exposed to welding fumes. Methods: Welding fumes were obtained from Kofar Ruwa, Kano by a skilled welder. 130 albino rats were purchased from the Animal Section of Department of Biological Sciences and were divided into 12 groups. They were given doses equivalent to the workers’ real life exposure regimes, and 1 group was selected as control group. They were administered intratracheally following anesthetization once weekly for twelve weeks. The rats were euthanized and serum samples were collected. Then, AChE activity was evaluated spectrophotometrically using ELISA kit (Sunlong Biotech Company). Results: The mean values of AChE ranged from 23.1 to 25.05 ng/mL with the control having a value of 24.7 ng/mL. Thus, there was a decrease in the values of AChE in the blood of treated groups, which was significantly different from the control (P<0.05). Conclusion: Metal welding fumes negatively affected the AChE by reducing its mean values. This implies that welding fumes possesses neurotoxic effects, which can lead to some neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Activity of acetylcholinesterase (AChE) in male albino rats exposed to metal welding fumes in an experimental setting

Adamu

Abdullahi

Ibrahim

2021

Environ Health Eng Manag

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“…However, plasma cholinesterase activity may vary as a function of exposure to other toxic compounds, depending on the exposure period. When studying the effect of exposure to iron on acetylcholinesterase (AChE) enzyme activity in fish brains and livers, Sant' Anna et al (2011) observed an increase of this enzyme 24 hours after exposure. Carvalho et al (2017) obtained similar results when they evaluated the activity of this enzyme in the brain of tadpoles after 48 hours of exposure to different types of heavy metals.…”

Section: Discussionmentioning

confidence: 99%

Plasma cholinesterase activity as an environmental impact biomarker in juvenile green turtles (Chelonia mydas)

et al. 2020

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The objective of this study was to evaluate the enzymatic activity of plasma cholinesterase in Chelonia mydas marine turtles belonging to two populations, according to their capture sites, under the absence and probable influence of anthropic effects. A total of 74 animals were used and later divided into two groups, based on the capture site. Blood samples were collected from all captured animals, which were then released into the sea at the site of capture. A descriptive statistical analysis of the plasma cholinesterase activity values and an analysis comparing these values based on the capture site were performed. Samples of heparinized plasma from animals captured at the two different sites were analyzed. Plasma cholinesterase activity ranged from 121 to 248U/L, with a mean and standard deviation of 186.1±30.68U/L. When comparing plasma cholinesterase activity values in individuals based on the capture site, a significant difference was observed. Establishing reference values for different sea turtle populations is necessary to interpret future sampling results and to allow sea turtles to be used as sentinels of ecosystem health. Future studies are needed to evaluate other populations and the activity of plasma cholinesterase in juvenile marine turtles, in relation to environmental contamination.

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“…It was determined that AChE activity is inhibited by metals like lead and zinc in the brain tissue of Danio rerio (Richetti et al, 2011).It is thought that the inhibition of AChE activity under the effect of lead is caused by binding of metals to the functional groups of proteins like imidazole, sulfhydryl and carboxyl (Najimi et al, 1997). Catalytic activity loss emerges because of this kind of changes in functional groups (Sant'Anna et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Effects of Lead and Selenium Interaction on Acetylcholinesterase Activity in Brain and Accumulation of Metal in Tissues of Oreochromis niloticus (L., 1758)

Şen¹,

Karaytuğ²

2017

Natural and Engineering Sciences

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The potential accumulation of lead in different tissues of Oreochromis niloticus and the effects of selenium in AChE inhibition caused by lead in brain were investigated. Juvenile O. niloticus samples were exposed to combination of 1 mg L-1 and 2 mg L-1 lead and 1mg L-1 lead+2mg L-1 selenium and 2mg L-1 lead+4mg L-1 selenium for 1, 7 and 15 days respectively. The accumulation of lead in gill, brain, liver and muscle tissues was analyzed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) as well as brain acetylcholinesterase (AChE, E.C.3.1.1.7) enzyme activity was also analyzed by spectrophotometric method. No mortality was observed during lead exposure in relation to time period and exposed concentrations. Lead accumulation was occurred in all tissues in relation to time. Maximum lead accumulation occurred in brain tissue, followed by the liver, gills and muscle tissues in relation to time period. Selenium caused a decrease on accumulation of lead in tissues (all selenium mixtures in muscle tissue on the first day, 1mg L-1 Pb+2mg L-1 selenium in gill tissue on the seventh day, in liver tissue on the seventh day except 2mg L-1 Pb+4mg L-1 selenium mixtures) at the end of each of all three test periods. Inhibition of AChE activity was caused by the highest concentration and by the short-term effect of lead. Such effect of lead was eliminated by selenium mixture. Lead and selenium mixture were resulted an increase in activity on 15th day at the highest concentration. Selenium led to decrease in the accumulation of lead in the tissues and caused to improvement in the loss of AChE activity.

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Iron exposure modifies acetylcholinesterase activity in zebrafish (Danio rerio) tissues: distinct susceptibility of tissues to iron overload

Cited by 22 publications

References 45 publications

Activity of acetylcholinesterase (AChE) in male albino rats exposed to metal welding fumes in an experimental setting

Activity of acetylcholinesterase (AChE) in male albino rats exposed to metal welding fumes in an experimental setting

Plasma cholinesterase activity as an environmental impact biomarker in juvenile green turtles (Chelonia mydas)

Effects of Lead and Selenium Interaction on Acetylcholinesterase Activity in Brain and Accumulation of Metal in Tissues of Oreochromis niloticus (L., 1758)

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