Iron (Fe)-doped mesoporous 45S5 bioactive glasses: Implications for cancer therapy

Kermani, Farzad; Vojdani-Saghir, Arghavan; Mollazadeh, Samaneh; Nazarnezhad, Simin; Mollaei, Zahra; Hamzehlou, Sepideh; El‐Fiqi, Ahmed; Baino, Francesco; Kargozar, Saeid

doi:10.1016/j.tranon.2022.101397

Cited by 44 publications

(20 citation statements)

References 44 publications

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“…In the co-doped systems, T g decreased from 773 to 556 °C. Consistent with the literature [ 17 ], the greatest changes in T g were expected for the Zn/Cu co-doped MBGs, as they have higher network disordering due to the high ionic repulsion force of the ions.…”

Section: Discussionsupporting

confidence: 87%

“…Traditionally, borate BGs are synthesized using the melt-quenching method, due to the inherent easiness of the process, but, on the other hand, the process needs specific equipment, such as high-temperature furnaces. Accordingly, the sol–gel method was gradually applied for the production of borate glasses with specific features, such as a porous texture, that makes them suitable candidates for drug delivery strategies [ 16 , 17 , 18 ]. However, expensive reagents (i.e., methoxy precursors) are generally required for producing sol–gel-derived borate glasses.…”

Section: Introductionmentioning

confidence: 99%

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Zinc- and Copper-Doped Mesoporous Borate Bioactive Glasses: Promising Additives for Potential Use in Skin Wound Healing Applications

Kermani

Nazarnezhad

Mollaei

et al. 2023

IJMS

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In this study, zinc (Zn)- and copper (Cu)-doped 13-93B3 borate mesoporous bioactive glasses (MBGs) were successfully synthesized using nitrate precursors in the presence of Pluronic P123. We benefited from computational approaches for predicting and confirming the experimental findings. The changes in the dynamic surface tension (SFT) of simulated body fluid (SBF) were investigated using the Du Noüy ring method to shed light on the mineralization process of hydroxyapatite (HAp) on the glass surface. The obtained MBGs were in a glassy state before incubation in SBF. The formation of an apatite-like layer on the SBF-incubated borate glasses was investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The incorporation of Zn and Cu into the basic composition of 13-93B3 glass led to changes in the glass transition temperature (Tg) (773 to 556 °C), particle size (373 to 64 nm), zeta potential (−12 to −26 mV), and specific surface area (SBET) (54 to 123 m2/g). Based on the K-means algorithm and chi-square automatic interaction detection (CHAID) tree, we found that the SFT of SBF is an important factor for the prediction and confirmation of the HAp mineralization process on the glasses. Furthermore, we proposed a simple calculation, based on SFT variation, to quantify the bioactivity of MBGs. The doped and dopant-free borate MBGs could enhance the proliferation of mouse fibroblast L929 cells at a concentration of 0.5 mg/mL. These glasses also induced very low hemolysis (<5%), confirming good compatibility with red blood cells. The results of the antibacterial test revealed that all the samples could significantly decrease the viability of Pseudomonas aeruginosa. In summary, we showed that Cu-/Zn-doped borate MBGs can be fabricated using a cost-effective method and also show promise for wound healing/skin tissue engineering applications, as especially supported by the cell test with fibroblasts, good compatibility with blood, and antibacterial properties.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Zinc- and Copper-Doped Mesoporous Borate Bioactive Glasses: Promising Additives for Potential Use in Skin Wound Healing Applications

Kermani

Nazarnezhad

Mollaei

et al. 2023

IJMS

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“…These synthetic materials exhibit outstanding biological properties, including excellent biocompatibility, the ability to bond to hard and soft tissues, and promotion of angiogenesis [ 6 , 7 , 8 ]. Over the years, specific types and compositions of BGs have been produced and applied for managing disorders outside the skeletal system [ 9 , 10 ]. In this sense, borate-based BGs have been synthesized in diverse formulations for the treatment of soft tissue injuries, either alone or in combination with biopolymers [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Modified Sol–Gel Synthesis of Mesoporous Borate Bioactive Glasses for Potential Use in Wound Healing

et al. 2022

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In this study, we successfully utilized nitrate precursors for the synthesis of silver (Ag)-doped borate-based mesoporous bioactive glass (MBGs) based on the 1393B3 glass formulation in the presence of a polymeric substrate (polyvinyl alcohol (PVA)) as a stabilizer of boric acid. The X-ray diffraction (XRD) analysis confirmed the glassy state of all the MBGs. The incorporation of 7.5 mol% Ag into the glass composition led to a decrease in the glass transition temperature (Tg). Improvements in the particle size, zeta potential, surface roughness, and surface area values were observed in the Ag-doped MBGs. The MBGs (1 mg/mL) had no adverse effect on the viability of fibroblasts. In addition, Ag-doped MBGs exhibited potent antibacterial activity against gram-positive and gram-negative species. In summary, a modified sol–gel method was confirmed for producing the Ag-doped 1393B3 glasses, and the primary in vitro outcomes hold promise for conducting in vivo studies for managing burns.

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“…In addition, multivalent ions (e.g., Fe 2+ /Fe 3+ ) can be released and regenerated continuously during the interaction of the doped HAp-NPs with the biological fluids. Potential changes during the ion transformation between different valences may be a critical factor in killing cancer cells [ 42 ]. Moreover, the release of Fe 2+ /Fe 3+ ions from Fe-doped HAp compositions plays a critical role in killing cancer cells through the Fenton reaction (Fe 2+ + H 2 O 2 → Fe 3+ + OH − + *OH), which can generate ROS in the tumor environments [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite Nanoparticles for Improved Cancer Theranostics

Kargozar

Mollazadeh

Kermani

et al. 2022

JFB

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Beyond their well-known applications in bone tissue engineering, hydroxyapatite nanoparticles (HAp NPs) have also been showing great promise for improved cancer therapy. The chemical structure of HAp NPs offers excellent possibilities for loading and delivering a broad range of anticancer drugs in a sustained, prolonged, and targeted manner and thus eliciting lower complications than conventional chemotherapeutic strategies. The incorporation of specific therapeutic elements into the basic composition of HAp NPs is another approach, alone or synergistically with drug release, to provide advanced anticancer effects such as the capability to inhibit the growth and metastasis of cancer cells through activating specific cell signaling pathways. HAp NPs can be easily converted to smart anticancer agents by applying different surface modification treatments to facilitate the targeting and killing of cancer cells without significant adverse effects on normal healthy cells. The applications in cancer diagnosis for magnetic and nuclear in vivo imaging are also promising as the detection of solid tumor cells is now achievable by utilizing superparamagnetic HAp NPs. The ongoing research emphasizes the use of HAp NPs in fabricating three-dimensional scaffolds for the treatment of cancerous tissues or organs, promoting the regeneration of healthy tissue after cancer detection and removal. This review provides a summary of HAp NP applications in cancer theranostics, highlighting the current limitations and the challenges ahead for this field to open new avenues for research.

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Iron (Fe)-doped mesoporous 45S5 bioactive glasses: Implications for cancer therapy

Cited by 44 publications

References 44 publications

Zinc- and Copper-Doped Mesoporous Borate Bioactive Glasses: Promising Additives for Potential Use in Skin Wound Healing Applications

Zinc- and Copper-Doped Mesoporous Borate Bioactive Glasses: Promising Additives for Potential Use in Skin Wound Healing Applications

Modified Sol–Gel Synthesis of Mesoporous Borate Bioactive Glasses for Potential Use in Wound Healing

Hydroxyapatite Nanoparticles for Improved Cancer Theranostics

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